SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150

The developing story of Sprouty and cancer

(2014) Samar Masoumi-Moghaddam et al.   CANCER AND METASTASIS REVIEWS

Bidirectional modulation of endogenous EpCAM expression to unravel its function in ovarian cancer

(2013) B T F van der Gun et al.   BRITISH JOURNAL OF CANCER

Epithelial Cell Adhesion Molecule (EpCAM) Regulates Claudin Dynamics and Tight Junctions

(2013) Chuan-Jin Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer

(2013) P Ordóñez-Morán et al.   ONCOGENE

EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins

(2012) Zili Lei et al.   DEVELOPMENTAL BIOLOGY

β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

(2012) Stephan P Tenbaum et al.   NATURE MEDICINE

A new model and modulator of pulmonary oedema

(2012) Charlotte Harrison   NATURE REVIEWS DRUG DISCOVERY

SIX1 promotes epithelial–mesenchymal transition in colorectal cancer through ZEB1 activation

(2012) H Ono et al.   ONCOGENE

Complex changes in alternative pre-mRNA splicing play a central role in the epithelial-to-mesenchymal transition (EMT)

(2012) Claude C. Warzecha et al.   SEMINARS IN CANCER BIOLOGY

The level of claudin-7 is reduced as an early event in colorectal carcinogenesis

(2011) Jette Bornholdt et al.   BMC CANCER

Deregulated expression of sprouty2 and microRNA-21 in human colon cancer: Correlation with the clinical stage of the disease

(2011) Yin-Hsun Feng et al.   CANCER BIOLOGY & THERAPY

Differential gene expression signatures between colorectal cancers with and without KRAS mutations: Crosstalk between the KRAS pathway and other signalling pathways

(2011) Toshiaki Watanabe et al.   EUROPEAN JOURNAL OF CANCER

Functional Cooperation between Snail1 and Twist in the Regulation ofZEB1Expression during Epithelial to Mesenchymal Transition

(2011) Natàlia Dave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression

(2011) Rhonda L. Brown et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP

(2011) K Horiguchi et al.   ONCOGENE

Sprouty 2 Is an Independent Prognostic Factor in Breast Cancer and May Be Useful in Stratifying Patients for Trastuzumab Therapy

(2011) Dana Faratian et al.   PLoS One

GATExplorer: Genomic and Transcriptomic Explorer; mapping expression probes to gene loci, transcripts, exons and ncRNAs

(2010) Alberto Risueño et al.   BMC BIOINFORMATICS

ZEB1-responsive genes in non-small cell lung cancer

(2010) Robert M. Gemmill et al.   CANCER LETTERS

Zeb1 and twist are more commonly expressed in metastatic than primary lung tumours and show inverse associations with claudins

(2010) H. Merikallio et al.   JOURNAL OF CLINICAL PATHOLOGY

Sprouty-2 controls c-Met expression and metastatic potential of colon cancer cells: sprouty/c-Met upregulation in human colonic adenocarcinomas

(2010) C Holgren et al.   ONCOGENE

SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity

(2010) A Barbáchano et al.   ONCOGENE

Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine

(2010) M. S. Buzza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway

(2009) Karin List et al.   AMERICAN JOURNAL OF PATHOLOGY

Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas

(2009) M. J. Frank et al.   BLOOD

HECT Domain-containing E3 Ubiquitin Ligase Nedd4 Interacts with and Ubiquitinates Sprouty2

(2009) Francis Edwin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Density-Dependent Inhibition of Epidermal Growth Factor Receptor Signaling by p38  Mitogen-Activated Protein Kinase via Sprouty2 Downregulation

(2009) A. Swat et al.   MOLECULAR AND CELLULAR BIOLOGY

Sprouty proteins, masterminds of receptor tyrosine kinase signaling

(2008) Miguel A. Cabrita et al.   ANGIOGENESIS

Defective Claudin-7 Regulation by Tcf-4 and Sox-9 Disrupts the Polarity and Increases the Tumorigenicity of Colorectal Cancer Cells

(2008) C. Darido et al.   CANCER RESEARCH

The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer

(2008) S. Spaderna et al.   CANCER RESEARCH

A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

(2008) C. P. Bracken et al.   CANCER RESEARCH

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

(2008) Ulrike Burk et al.   EMBO REPORTS

The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional RepressorsZEB1andZEB2

(2008) Manav Korpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell polarity and cancer - cell and tissue polarity as a non-canonical tumor suppressor

(2008) M. Lee et al.   JOURNAL OF CELL SCIENCE

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY

Epigenetic inactivation of the ERK inhibitor Spry2 in B-cell diffuse lymphomas

(2008) A Sánchez et al.   ONCOGENE

Hypermethylation-Modulated Downregulation of Claudin-7 Expression Promotes the Progression of Colorectal Carcinoma

(2008) Fumihito Nakayama et al.   PATHOBIOLOGY