Targeting the Acidic Tumor Microenvironment: Unexpected Pro-Neoplastic Effects of Oral NaHCO3 Therapy in Murine Breast Tissue
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Targeting the Acidic Tumor Microenvironment: Unexpected Pro-Neoplastic Effects of Oral NaHCO3 Therapy in Murine Breast Tissue
Authors
Keywords
-
Journal
Cancers
Volume 12, Issue 4, Pages 891
Publisher
MDPI AG
Online
2020-04-07
DOI
10.3390/cancers12040891
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Therapeutic Targeting of Cancer Stem Cells: Integrating and Exploiting the Acidic Niche
- (2019) Catherine Vander Linden et al. Frontiers in Oncology
- Crucial role of the pentose phosphate pathway in malignant tumors (Review)
- (2019) Lin Jin et al. Oncology Letters
- Causes, consequences, and therapy of tumors acidosis
- (2019) Smitha R. Pillai et al. CANCER AND METASTASIS REVIEWS
- The Acidic Tumor Microenvironment as a Driver of Cancer
- (2019) Ebbe Boedtkjer et al. Annual Review of Physiology
- Roles of pH in control of cell proliferation
- (2018) M. Flinck et al. Acta Physiologica
- The acid-base transport proteins NHE1 and NBCn1 regulate cell cycle progression in human breast cancer cells
- (2018) Mette Flinck et al. CELL CYCLE
- Na+,HCO3–-cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice
- (2018) Soojung Lee et al. ONCOGENE
- A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells
- (2018) Sina Ibne Noor et al. eLife
- Value of pH regulators in the diagnosis, prognosis and treatment of cancer
- (2017) Sara Granja et al. SEMINARS IN CANCER BIOLOGY
- Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation
- (2017) Veronica Huber et al. SEMINARS IN CANCER BIOLOGY
- Crosstalk between cardiomyocyte-rich perivascular tissue and coronary arteries is reduced in the Zucker Diabetic Fatty rat model of type 2 diabetes mellitus
- (2016) L. Bonde et al. Acta Physiologica
- Na + /H + antiporter (NHE1) and lactate/H + symporters (MCTs) in pH homeostasis and cancer metabolism
- (2016) Laurent Counillon et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Na+, HCO3−-cotransporter NBCn1 increases pHigradients, filopodia, and migration of smooth muscle cells and promotes arterial remodelling
- (2016) Ebbe Boedtkjer et al. CARDIOVASCULAR RESEARCH
- Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation
- (2016) Cyril Corbet et al. Cell Metabolism
- Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment
- (2016) Anne Poder Andersen et al. Molecular Cancer
- The Perseus computational platform for comprehensive analysis of (prote)omics data
- (2016) Stefka Tyanova et al. NATURE METHODS
- The MaxQuant computational platform for mass spectrometry-based shotgun proteomics
- (2016) Stefka Tyanova et al. Nature Protocols
- Systematic review of the association between dietary acid load, alkaline water and cancer
- (2016) Tanis R Fenton et al. BMJ Open
- Carbonic Anhydrase IX Promotes Myeloid-Derived Suppressor Cell Mobilization and Establishment of a Metastatic Niche by Stimulating G-CSF Production
- (2015) S. C. Chafe et al. CANCER RESEARCH
- Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy
- (2015) Shari Pilon-Thomas et al. CANCER RESEARCH
- Disrupting Na+,HCO3–-cotransporter NBCn1 (Slc4a7) delays murine breast cancer development
- (2015) S Lee et al. ONCOGENE
- CXCR4 in breast cancer: oncogenic role and therapeutic targeting
- (2015) Qinghua Yao et al. Drug Design Development and Therapy
- Targeting lactate transport suppresses in vivo breast tumour growth
- (2015) Filipa Morais-Santos et al. Oncotarget
- The SIRT1/HIF2 Axis Drives Reductive Glutamine Metabolism under Chronic Acidosis and Alters Tumor Response to Therapy
- (2014) C. Corbet et al. CANCER RESEARCH
- Current Status of Bicarbonate in CKD
- (2014) M. Dobre et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Na+,HCO3 −-cotransport is functionally upregulated during human breast carcinogenesis and required for the inverted pH gradient across the plasma membrane
- (2014) Soojung Lee et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Regulation and roles of bicarbonate transporters in cancer
- (2014) Andrej Gorbatenko et al. Frontiers in Physiology
- Interleukin-8 in Breast Cancer Progression
- (2013) Nataša Todorović-Raković et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Nitric oxide and cancer: a review
- (2013) Sheetal Korde Choudhari et al. World Journal of Surgical Oncology
- Physiology, Pharmacology and Pathophysiology of the pH Regulatory Transport Proteins NHE1 and NBCn1: Similarities, Differences, and Implications for Cancer Therapy
- (2012) E. Boedtkjer et al. CURRENT PHARMACEUTICAL DESIGN
- Contribution of Na+,HCO3−-cotransport to cellular pH control in human breast cancer: A role for the breast cancer susceptibility locus NBCn1 (SLC4A7)
- (2012) Ebbe Boedtkjer et al. INTERNATIONAL JOURNAL OF CANCER
- Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress
- (2012) Maria Lucia Marino et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NHE1 knockout reduces blood pressure and arterial media/lumen ratio with no effect on resting pHiin the vascular wall
- (2012) Ebbe Boedtkjer et al. JOURNAL OF PHYSIOLOGY-LONDON
- Systemic Buffers Inhibit Carcinogenesis in TRAMP Mice
- (2012) Arig Ibrahim-Hashim et al. JOURNAL OF UROLOGY
- Modulation of autophagic activity by extracellular pH
- (2011) Teng Xu et al. Autophagy
- Bicarbonate and dichloroacetate: Evaluating pH altering therapies in a mouse model for metastatic breast cancer
- (2011) Ian F Robey et al. BMC CANCER
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Disruption of Na + ,HCO 3 − Cotransporter NBCn1 (slc4a7) Inhibits NO-Mediated Vasorelaxation, Smooth Muscle Ca 2+ Sensitivity, and Hypertension Development in Mice
- (2011) Ebbe Boedtkjer et al. CIRCULATION
- The normal acid–base status of mice
- (2011) Nina K. Iversen et al. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
- NBCn1 and NHE1 expression and activity in ΔNErbB2 receptor-expressing MCF-7 breast cancer cells: Contributions to pHi regulation and chemotherapy resistance
- (2010) G. Lauritzen et al. EXPERIMENTAL CELL RESEARCH
- Reactive oxygen species in cancer
- (2010) Geou-Yarh Liou et al. FREE RADICAL RESEARCH
- A mathematical model of tumour and blood pHe regulation: The buffering system
- (2010) Natasha K. Martin et al. MATHEMATICAL BIOSCIENCES
- Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases
- (2009) I. F. Robey et al. CANCER RESEARCH
- Bladder cancer SNP panel predicts susceptibility and survival
- (2009) Angeline S. Andrew et al. HUMAN GENETICS
- The Role of Carbonic Anhydrase 9 in Regulating Extracellular and Intracellular pH in Three-dimensional Tumor Cell Growths
- (2009) Pawel Swietach et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Acid treatment of melanoma cells selects for invasive phenotypes
- (2008) Raymond E. Moellering et al. CLINICAL & EXPERIMENTAL METASTASIS
- Cancer angiogenesis: Targeting the heel of Achilles
- (2008) Crispin R. Dass et al. JOURNAL OF DRUG TARGETING
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started