EpCAM-high liver cancer stem cells resist natural killer cell–mediated cytotoxicity by upregulating CEACAM1

High Serum Levels of Cholesterol Increase Anti-tumor Functions of Nature Killer Cells and Reduce Growth of Liver Tumors in Mice

(2020) Wen-Hao Qin et al.   GASTROENTEROLOGY

Overshadowed prospect of programmed cell death protein-1 (PD-1) inhibitor as monotherapy for patients with advanced hepatocellular carcinoma

(2019) Xu Yao et al.   BioScience Trends

Natural killer cells target and differentiate cancer stem-like cells/undifferentiated tumors: strategies to optimize their growth and expansion for effective cancer immunotherapy

(2018) Kawaljit Kaur et al.   CURRENT OPINION IN IMMUNOLOGY

Single-cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma

(2018) Hongping Zheng et al.   HEPATOLOGY

EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

(2018) Peter R. Galle et al.   JOURNAL OF HEPATOLOGY

The EpCAM overexpression is associated with clinicopathological significance and prognosis in hepatocellular carcinoma patients: A systematic review and meta-analysis

(2018) Linhua Zhou et al.   International Journal of Surgery

Super-charged NK cells inhibit growth and progression of stem-like/poorly differentiated oral tumors in vivo in humanized BLT mice; effect on tumor differentiation and response to chemotherapeutic drugs

(2018) Kawaljit Kaur et al.   OncoImmunology

Challenges of NK cell-based immunotherapy in the new era

(2018) Fang Fang et al.   Frontiers of Medicine

Natural Killer Cell Dysfunction in Hepatocellular Carcinoma: Pathogenesis and Clinical Implications

(2018) Pil Soo Sung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CEACAM1 in Liver Injury, Metabolic and Immune Regulation

(2018) Andrea Horst et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AASLD guidelines for the treatment of hepatocellular carcinoma

(2017) Julie K. Heimbach et al.   HEPATOLOGY

Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

(2017) Anthony B El-Khoueiry et al.   LANCET

Differentiation by NK cells is a prerequisite for effective targeting of cancer stem cells/poorly differentiated tumors by chemopreventive and chemotherapeutic drugs

(2017) Anna Kozlowska et al.   Journal of Cancer

CXCL10 is produced in hepatitis A virus-infected cells in an IRF3-dependent but IFN-independent manner

(2017) Pil Soo Sung et al.   Scientific Reports

Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-γ after differentiation of glioblastoma by human natural killer cells

(2016) Anna K. Kozlowska et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Human cancer cells with stem cell-like phenotype exhibit enhanced sensitivity to the cytotoxicity of IL-2 and IL-15 activated natural killer cells

(2016) Tao Yin et al.   CELLULAR IMMUNOLOGY

Targeting Cancer Stem Cells with Natural Killer Cell Immunotherapy

(2016) Jesus I. Luna et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes

(2016) Saravana Kumar Kailasam Mani et al.   JOURNAL OF HEPATOLOGY

Genetic profiling of hepatocellular carcinoma using next-generation sequencing

(2016) Kornelius Schulze et al.   JOURNAL OF HEPATOLOGY

Targeting natural killer cells in cancer immunotherapy

(2016) Camille Guillerey et al.   NATURE IMMUNOLOGY

Activation of human natural killer cells by the soluble form of cellular prion protein

(2015) Yeon-Jae Seong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NK Cells Preferentially Target Tumor Cells with a Cancer Stem Cell Phenotype

(2015) Erik Ames et al.   JOURNAL OF IMMUNOLOGY

The Human Antibody Fragment DIATHIS1 Specific for CEACAM1 Enhances Natural Killer Cell Cytotoxicity Against Melanoma Cell Lines In Vitro

(2015) Maria L. Dupuis et al.   JOURNAL OF IMMUNOTHERAPY

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

(2015) Kornelius Schulze et al.   NATURE GENETICS

Present and Future of Allogeneic Natural Killer Cell Therapy

(2015) Okjae Lim et al.   Frontiers in Immunology

CEACAM1 Long Cytoplasmic Domain Isoform is Associated with Invasion and Recurrence of Hepatocellular Carcinoma

(2014) Shigehisa Kiriyama et al.   ANNALS OF SURGICAL ONCOLOGY

Metastatic Consequences of Immune Escape from NK Cell Cytotoxicity by Human Breast Cancer Stem Cells

(2014) B. Wang et al.   CANCER RESEARCH

Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition

(2013) Eric O. Long et al.   Annual Review of Immunology

Cancer stem cells in the development of liver cancer

(2013) Taro Yamashita et al.   JOURNAL OF CLINICAL INVESTIGATION

Discrete nature of EpCAM+and CD90+cancer stem cells in human hepatocellular carcinoma

(2012) Taro Yamashita et al.   HEPATOLOGY

Monocyte/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions

(2012) Yan Wu et al.   HEPATOLOGY

CD133+ liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma

(2011) Lian Shu Piao et al.   CANCER LETTERS

Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma

(2011) Valerie Chew et al.   GUT

CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells

(2011) Zhangguo Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epithelial cell adhesion molecule (EpCAM) marks hepatocytes newly derived from stem/progenitor cells in humans

(2010) So-Mi Yoon et al.   HEPATOLOGY

EpCAM, a new marker for cancer stem cells in hepatocellular carcinoma

(2009) Benoit Terris et al.   JOURNAL OF HEPATOLOGY

EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features

(2008) Taro Yamashita et al.   GASTROENTEROLOGY