The activity of sulfono-γ-AApeptide helical foldamers that mimic GLP-1

α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53–MDM2/MDMX Protein–Protein Interactions

(2020) Peng Sang et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Generation Oxyntomodulin Peptides with Improved Pharmacokinetic Profiles Exhibit Weight Reducing and Anti-Steatotic Properties in Mice

(2020) Peng-Yu Yang et al.   BIOCONJUGATE CHEMISTRY

Peptide-oligourea hybrids analogue of GLP-1 with improved action in vivo

(2019) Juliette Fremaux et al.   Nature Communications

Orthogonal Halogen-Bonding-Driven 3D Supramolecular Assembly of Right-Handed Synthetic Helical Peptides

(2019) Peng Teng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibition of β-catenin/B cell lymphoma 9 protein−protein interaction using α-helix–mimicking sulfono-γ-AApeptide inhibitors

(2019) Peng Sang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Helical Sulfono-γ-AApeptides with Aggregation-Induced Emission and Circularly Polarized Luminescence

(2019) Yan Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

O-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity

(2019) Paul M. Levine et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

De Novo Left-Handed Synthetic Peptidomimetic Foldamers

(2018) Fengyu She et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

(2018) Daniel J. Drucker   Cell Metabolism

Hydrogen-Bonding-Driven 3D Supramolecular Assembly of Peptidomimetic Zipper

(2018) Peng Teng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of the GLP-1 receptor bound to a peptide agonist

(2017) Ali Jazayeri et al.   NATURE

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

(2017) Yan Zhang et al.   NATURE

γ-AApeptides: Design, Structure, and Applications

(2016) Yan Shi et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Cardiovascular Biology of Glucagon-like Peptide-1

(2016) Daniel J. Drucker   Cell Metabolism

β-Arrestin-Biased Agonists of the GLP-1 Receptor from β-Amino Acid Residue Incorporation into GLP-1 Analogues

(2016) Marlies V. Hager et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists

(2015) Huy N. Hoang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glucagon-like Peptide-1 (GLP-1) Analogs: Recent Advances, New Possibilities, and Therapeutic Implications

(2014) Bikash Manandhar et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Potent α/β-Peptide Analogue of GLP-1 with Prolonged Action in Vivo

(2014) Lisa M. Johnson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Suppression of Food Intake by Glucagon-Like Peptide-1 Receptor Agonists: Relative Potencies and Role of Dipeptidyl Peptidase-4

(2012) Lene Jessen et al.   ENDOCRINOLOGY

Characterization of a Designed Vascular Endothelial Growth Factor Receptor Antagonist Helical Peptide with Antiangiogenic Activity in Vivo

(2011) Anna Basile et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of Potent Glucagon-like Peptide-1 Agonists with High Enzyme Stability via Introduction of Multiple Lactam Bridges

(2010) Eunice N. Murage et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor

(2009) Christina Rye Underwood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain

(2008) Steffen Runge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and Synthesis of Conformationally Constrained Glucagon-Like Peptide-1 Derivatives with Increased Plasma Stability and Prolonged in Vivo Activity

(2008) Les P. Miranda et al.   JOURNAL OF MEDICINAL CHEMISTRY