Article
Materials Science, Biomaterials
Cheng Hu, Wenqi Liu, Linyu Long, Zhicun Wang, Yihui Yuan, Wen Zhang, ShuYi He, Jian Wang, Li Yang, Lu Lu, Yunbing Wang
Summary: A new multifunctional smart hydrogel was developed for the treatment of chronic diabetic wounds, which achieved on-demand release of antibacterial nanoparticles and tailored rhCol III to promote wound healing. The released nanoparticles demonstrated excellent antibacterial properties, while the rhCol III promoted cell proliferation and migration to accelerate wound healing.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Julie Tzu-Wen Wang, Ana C. Rodrigo, Anna K. Patterson, Kirsten Hawkins, Mazen M. S. Aly, Jia Sun, Khuloud T. Al Jamal, David K. Smith
Summary: The study demonstrates the use of a self-assembling hydrogel as a delivery vehicle for the Parkinson's disease drug l-DOPA, showing promising results for nasal drug delivery strategies.
Article
Engineering, Biomedical
Minmengqi Pan, Zhibin Ren, Xiaohui Ma, Lei Chen, Guanghao Lv, Xiaoying Liu, Shan Li, Xingyi Li, Jiaqing Wang
Summary: In this study, an antibiotic hydrogel eye drop was developed to extend the pre-corneal retention of drugs. The self-assembly ability of peptide-drug conjugate and the addition of calcium ions were utilized to improve drug delivery efficacy. This biomimetic design of antibiotic eye drops addresses the current issues of ocular drug delivery and provides potential solutions for treating bacterial keratitis.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Han Wang, Hao Su, Tian Xu, Honggang Cui
Summary: Non-ionic hydrogels are of interest for long-term therapeutic implantation due to their low immunogenicity. This study reports the formation of non-ionic supramolecular polymer hydrogels triggered by salt. The hydrogels exhibit sustained release of an anticancer drug and potent activity against cancer cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Tiankuo Wang, Yu Zhang, Zichen Gu, Wei Cheng, Hai Lei, Meng Qin, Bin Xue, Wei Wang, Yi Cao
Summary: This study reveals that the mechanical properties of polymer-supramolecular double-network hydrogels can be significantly improved by tuning the supramolecular network structures, leading to higher Young's modulus, fracture stress, and toughness, as well as slightly faster recovery rates.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Polymer Science
Pan Wu, Yaru Fang, Kezhou Chen, Mi Wu, Wenchang Zhang, Shiyu Wang, Dongwen Liu, Junqing Gao, Huaiguo Li, Jianhua Lv, Yan Zhao
Summary: Double network (DN) hydrogels were formed by covalent crosslinking and physical crosslinking using sodium methacrylate alginate (MASA) and carboxymethyl chitosan (CMCS). The addition of poly(ethylene glycol) diacrylate (PEGDA) as a crosslinker significantly improved the compressive strength and light transmittance of the hydrogels. The drug release behavior of the DN hydrogels was pH sensitive and correlated with the content of PEGDA.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Jiawei Lin, Liang Chen, Jielai Yang, Xingchen Li, Juan Wang, Yuan Zhu, Xiangyang Xu, Wenguo Cui
Summary: This study presents a functional hydrogel microsphere designed for efficient drug delivery to joints. The microspheres exhibit targeting properties, cartilage penetration, and cellular phagocytosis, addressing the challenges of drug delivery in damaged tissues. The microspheres can be adsorbed onto the cartilage surface and release drugs over an extended period of time, effectively improving drug delivery efficiency and delaying the development of osteoarthritis.
Article
Materials Science, Multidisciplinary
Xinxin Huang, Jingchao Li, Jing Luo, Qiang Gao, An Mao, Jianzhang Li
Summary: Research on double-network (DN) hydrogels with good biocompatibility and mechanical properties has been flourishing recently. These hydrogels have significant advantages in mechanical properties, structure, biocompatibility, and various potential applications. Focus is on enhancement mechanisms, preparation methods, and applications in different fields, breaking away from current limitations and providing new ideas for future development.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Xianglian Li, Hui Liu, Ailing Yu, Dan Lin, Zhishu Bao, Yuqin Wang, Xingyi Li
Summary: The newly designed NapFFKKFKLKL/Dexp supramolecular hydrogel displayed controlled drug release behavior, good intraocular biocompatibility, and potent anti-inflammatory capacity, making it a promising drug carrier system for treating posterior disorders such as uveitis.
CHINESE CHEMICAL LETTERS
(2021)
Article
Engineering, Environmental
Ailing Yu, Yuhan Hu, Xiaohui Ma, Lihua Mo, Minmengqi Pan, Xiuqing Bi, Yuqin Wu, Jiaqing Wang, Xingyi Li
Summary: The research introduces a novel supramolecular hydrogel for synergistic therapy to treat endophthalmitis, delivering antibiotics and anti-inflammatory agents effectively with high antibacterial activities.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Biomedical
Han Zhang, Kai Liu, Yimou Gong, Wenjun Zhu, Jiafei Zhu, Feng Pan, Yu Chao, Zhishen Xiao, Yanbin Liu, Xianwen Wang, Zhuang Liu, Yang Yang, Qian Chen
Summary: This study presents the use of a novel Vitamin C nanofiber hydrogel as a platform for enhanced cancer immunotherapy. The hydrogel not only serves as a reservoir for Vitamin C but also exhibits anti-tumor effects. The encapsulated stimulator of interferon genes (STING) agonist synergistically activates the immune system to inhibit the progression of tumors.
Article
Engineering, Biomedical
Shu Hui Hiew, Jun Kit Wang, Kenrick Koh, Haibo Yang, Abbas Bacha, Junquan Lin, Yun Sheng Yip, Marcus Ivan Gerard Vos, Liyan Chen, Radoslaw M. Sobota, Nguan Soon Tan, Chor Yong Tay, Ali Miserez
Summary: The bioinspired octapeptide GV8 can self-assemble into biodegradable physical hydrogels, encapsulating macromolecular therapeutics and exhibiting controlled drug release. It shows promise for wound healing applications by maintaining growth factor activity and promoting epithelial cell migration. This versatile and safe carrier represents a promising biomaterial for regenerative medicine applications.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Huilei Dong, Mingshui Wang, Shihui Fan, Chuanliu Wu, Chunhui Zhang, Xia Wu, Bin Xue, Yi Cao, Junjie Deng, Dan Yuan, Junfeng Shi
Summary: This study reports the folding of a thiol-rich peptide into an amphiphilic beta-hairpin conformation through the formation of two hetero-disulfide bonds, and its subsequent self-assembly into a hydrogel. It is the first case of using multiple disulfide bonds to control conformational change and self-assembly, providing a cell-compatible hydrogel material for potential biomedical applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Biomedical
Shaodan Ma, Shunan Gu, Jinwei Zhang, Weizhong Qi, Zhaowei Lin, Weicheng Zhai, Jie Zhan, Qi Li, Yanbin Cai, Yao Lu
Summary: The conjugation of methotrexate with a supramolecular self-assembling hydrogel composed of D-amino acids has shown to enhance drug toxicity towards rheumatoid arthritis synoviocytes while reducing toxicity towards normal cells, effectively inhibiting the proliferation and migration of synoviocytes and reducing inflammation.
MATERIALS TODAY BIO
(2022)
Article
Materials Science, Multidisciplinary
Jing Zhang, Sunxiang Qian, Lingdong Chen, Liqun Chen, Liping Zhao, Jie Feng
Summary: A newly developed double network hydrogel based on SBMA and SA exhibits excellent mechanical properties, biocompatibility, and antifouling properties, making it a promising candidate for biomedical applications. The hybrid crosslinked structure of the DN hydrogel provides it with unique characteristics suitable for artificial connective tissues, implantable devices, and underwater equipment.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)