Article
Gastroenterology & Hepatology
Aristeidis Grigoriadis, Kristina Imeen Ringe, Johan Bengtsson, Erik Baubeta, Cecilia Forsman, Nafsika Korsavidou-Hult, Fredrik Rorsman, Emma Nilsson, Nikolaos Kartalis, Annika Bergquist
Summary: Magnetic resonance cholangiopancreatography (MRCP) plays an important role in the prognosis assessment of primary sclerosing cholangitis (PSC). A novel, simple, and reproducible risk-score (DiStrict score) based on MRCP findings was developed and showed a strong association with prognosis in individuals with PSC. This score can be easily used in clinical practice and has the potential to be useful in clinical trials and patient counseling and management.
Article
Gastroenterology & Hepatology
Ehud Zigmond, Britta Franziska Zecher, Anna-Lena Bartels, Tomer Ziv-Baran, Thomas Roesch, Guido Schachschal, Ansgar W. Lohse, Hanno Ehlken, Christoph Schramm
Summary: Primary sclerosing cholangitis (PSC) is characterized by chronic inflammation of the biliary mucosa and colonization of the bile ducts with bacteria. This study found that the presence of Enterococci and Fungobilia in the bile ducts of PSC patients was associated with disease progression, highlighting the importance of microbiota-mucosal interaction in the pathogenesis of PSC.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
John E. Eaton, Abdul Haseeb, Christian Rupp, Leonardo H. Eusebi, Kim Munster, Robert Voitl, Douglas Thorburn, Cyriel Y. Ponsioen, Felicity T. Enders, Bret T. Petersen, Barham K. Abu Dayyeh, Todd H. Baron, Vinay Chandrasekhara, Christopher J. Gostout, Michael J. Levy, John Martin, Andrew C. Storm, Ross Dierkhising, Patrick S. Kamath, Gregory J. Gores, Mark Topazian
Summary: The resolution of jaundice after endoscopic treatment of biliary strictures in patients with primary sclerosing cholangitis (PSC) is associated with longer transplant-free survival. Predictors of jaundice resolution include age, duration of jaundice, Mayo Risk Score, and the location of the most advanced biliary stricture. Other factors, such as higher Mayo Risk Score at the time of ERCP, lower pre-ERCP total serum bilirubin, and persistence of jaundice after endoscopic therapy, may predict the risk of death or transplant in patients with PSC.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Nora Cazzagon, Ester Gonzalez-Sanchez, Haquima El-Mourabit, Dominique Wendum, Dominique Rainteau, Lydie Humbert, Christophe Corpechot, Olivier Chazouilleres, Lionel Arrive, Chantal Housset, Sara Lemoinne
Summary: In patients with primary sclerosing cholangitis (PSC), the gallbladder status affects bile acid homeostasis and disease features. Evidence suggests less bile acid toxicity in patients with enlarged gallbladders and increased disease severity in those who had undergone cholecystectomy. In a mouse model of PSC, cholecystectomy worsened cholangitis and liver fibrosis. Overall, the gallbladder plays a protective role in PSC.
Article
Radiology, Nuclear Medicine & Medical Imaging
Marwa F. Ismail, Gideon M. Hirschfield, Bettina Hansen, Monica Tafur, Khaled Y. Elbanna, Marc H. Goldfinger, Gerard R. Ridgway, Kartik S. Jhaveri
Summary: MRCP+ showed significant associations with biochemical scores and MRE, with its association with biochemical scores comparable to ANALI scores. MRCP+ enhanced the associations of ANALI2 and MRE with the Mayo Risk Score.
EUROPEAN RADIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Natassia Tan, John Lubel, William Kemp, Stuart Roberts, Ammar Majeed
Summary: Primary sclerosing cholangitis (PSC) is an orphan, cholestatic liver disease characterized by inflammatory biliary strictures. The pathophysiology of PSC is poorly understood, but it is likely driven by immune dysregulation, gut dysbiosis, and environmental exposures. Currently, there is no proven medical therapy to alter disease progression in PSC, and liver transplantation is the only option for end-stage liver disease. Manipulation of the gut microbiome and bile acid metabolism show promise in phase II trials. Statins and aspirin may reduce the risk of malignancy in PSC patients. Balloon dilatation is safer and equally effective compared to biliary stent insertion for clinically relevant strictures.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Multidisciplinary Sciences
Agnieszka Kempinska-Podhorodecka, Monika Adamowicz, Ewa Ostrycharz, Mateusz Chmielarz, Maciej Wojcicki, Piotr Milkiewicz, Malgorzata Milkiewicz
Summary: The study found that miR-506 is significantly upregulated in the colon of patients with PSC and PSC+UC, but downregulated in patients with UC. This differential expression may be associated with phenotypic presentations of colonic inflammation and neoplasia. Upregulation of miR-506 in PSC and PSC+UC patients may lead to failure of bicarbonate secretion and inhibition of p53, while downregulation of miR-506 in UC patients enhances S1P production, leading to pro-inflammatory signaling.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sarah Poetter-Lang, Alina Messner, Nina Bastati, Kristina I. Ringe, Maxime Ronot, Sudhakar K. Venkatesh, Raphael Ambros, Antonia Kristic, Aida Korajac, Gregor Dovjak, Martin Zalaudek, Jacqueline. C. Hodge, Christoph Schramm, Emina Halilbasic, Michael Trauner, Ahmed Ba-Ssalamah
Summary: T1-MRC was found to be superior to T2-MRCP in diagnosing and locating strictures, as well as predicting prognosis in patients with primary sclerosing cholangitis.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Soleen Ghafoor, Manon Germann, Christoph Juengst, Beat Muellhaupt, Cacilia S. Reiner, Daniel Stocker
Summary: COVID-19-associated secondary sclerosing cholangitis presents with intrahepatic bile duct strictures, upstream dilatation, and bile duct beading on MRI/MRCP, with the extrahepatic biliary tree and periportal lymph nodes being typically spared.
INSIGHTS INTO IMAGING
(2022)
Article
Oncology
Katsuyuki Miyabe, Vinay Chandrasekhara, Nicha Wongjarupong, Jun Chen, Lu Yang, Stephen Johnson, Nicholas Chia, Marina Walther-Antonio, Janet Z. Yao, Sean C. Harrington, Cynthia K. Nordyke, John E. Eaton, Andrea A. Gossard, Sharad Oli, Hamdi A. Ali, Sravanthi Lavu, Nasra H. Giama, Fatima A. Hassan, Hawa M. Ali, Felicity T. Enders, Sumera I. Ilyas, Gregory J. Gores, Mark D. Topazian, Purna C. Kashyap, Lewis R. Roberts
Summary: This study investigated the microbiota profiles in bile and stool samples of patients with PSC and CCA, and found that bile and stool have different microbiota profiles. The abundance of Fusobacteria in bile was correlated with the duration of PSC in CCA patients. These findings suggest a potential role for microbiota-driven inflammation in the pathogenesis of perihilar CCA.
Article
Gastroenterology & Hepatology
Jun Seong Hwang, Sung Woo Ko
Summary: Duplication of the extrahepatic bile duct (DCBD) is an extremely rare congenital anomaly with five types, among which Type V is characterized by single drainage of the extrahepatic bile ducts. This case report highlights the importance of recognizing DCBD, as stones in the unrecognized bile duct could have critical consequences for the patient's prognosis. In this case, a patient with DCBD Type Va and remnant choledocholithiasis was successfully treated with ERCP and magnetic resonance cholangiopancreatography.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Christina Villard, Ingalill Friis-Liby, Fredrik Rorsman, Karouk Said, Anna Warnqvist, Martin Cornillet, Stergios Kechagias, Nils Nyhlin, Marten Werner, Izabella Janczewska, Therese Hagstrom, Emma Nilsson, Annika Bergquist
Summary: This study prospectively evaluated the effectiveness of yearly MRI/MRCP surveillance in detecting cholangiocarcinoma (CCA) in patients with primary sclerosing cholangitis (PSC) and found it to be ineffective in detecting cancer early enough to support long-term survival. Personalized follow-up strategies and improved diagnostic methods for PSC-related CCA are needed.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
European Assoc Study Liver
Summary: This article presents guidelines for the management of primary or secondary sclerosing cholangitis, covering topics such as diagnostic methods, prognostic assessment, early detection of complications, optimal care pathways, and therapeutic options for both adults and children.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Qiaoyan Liu, Bo Li, Yikang Li, Yiran Wei, Bingyuan Huang, Jubo Liang, Zhengrui You, You Li, Qiwei Qian, Rui Wang, Jun Zhang, Ruiling Chen, Zhuwan Lyu, Yong Chen, Mingxia Shi, Xiao Xiao, Qixia Wang, Qi Miao, Jing-Yuan Fang, Merrill Eric Gershwin, Min Lian, Xiong Ma, Ruqi Tang
Summary: Comparative analysis of gut microbiome and metabolome in IgG4-SC and PSC patients revealed distinct host-microbe interactions that may contribute to disease pathogenesis, highlighting the uniqueness of IgG4-SC.
Article
Gastroenterology & Hepatology
John E. Eaton, Christopher L. Welle, Zeinab Bakhshi, Shannon P. Sheedy, Ilkay S. Idilman, Gregory J. Gores, Charles B. Rosen, Julie K. Heimbach, Timucin Taner, Denise M. Harnois, Keith D. Lindor, Nicholas F. LaRusso, Andrea A. Gossard, Konstantinos N. Lazaridis, Sudhakar K. Venkatesh
Summary: This study aimed to evaluate the diagnostic performances and prognostic implications of ultrasound and MRI-based perihilar cholangiocarcinoma (CCA) detection among patients with primary sclerosing cholangitis (PSC). Results showed that MRI was superior to ultrasound for the detection of early-stage CCA in PSC patients, and identifying CCA before symptom onset with MRI was associated with improved outcomes.
Editorial Material
Gastroenterology & Hepatology
Ali Dean Tahboub Amawi, William J. Tremaine, Sudhakar K. Venkatesh
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sudhakar K. Venkatesh, Michael S. Torbenson
Summary: Liver fibrosis is the healing response to chronic liver injury and is the endpoint of chronic liver disease, significantly impacting long-term liver-related clinical outcomes. Liver biopsy is the traditional method for staging, but it is invasive and susceptible to sampling errors. Non-invasive tests, including serum tests and imaging biomarkers, play important roles in clinical care. Understanding the pathogenesis of liver fibrosis is crucial for the evaluation and application of these non-invasive tests.
ABDOMINAL RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tolga Gidener, Ross A. Dierkhising, Kristin C. Mara, Terry M. Therneau, Sudhakar K. Venkatesh, Richard L. Ehman, Meng Yin, Alina M. Allen
Summary: This study investigated the progression of NAFLD using longitudinal liver stiffness measurements and found that it is associated with liver-related outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew D. Hardie, Jordan H. Chamberlin, James H. Boyum, Kedar G. Sharbidre, Robert Petrocelli, Brian P. Flemming, Mohd Zahid, Sudhakar K. Venkatesh, Smitha Mruthyunjayappa, Cristina H. Hajdu, Mark D. Kovacs
Summary: This study developed a highly accurate classification system using machine learning and a multi-center study design to differentiate mucinous cystic neoplasm (MCN) from a benign hepatic cyst (BHC) in the liver. The system could be readily applied to clinical practice.
ACADEMIC RADIOLOGY
(2022)
Letter
Gastroenterology & Hepatology
Tolga Gidener, Ross Dierkhising, Kristin C. Mara, Terry M. Therneau, Sudhakar K. Venkatesh, Richard L. Ehman, Meng Yin, Alina M. Allen
Review
Pathology
Michael Torbenson, Sudhakar K. Venkatesh, Thorvardur R. Halfdanarson, Patrick J. Navin, Patrick Kamath, Lori A. Erickson
Summary: Primary hepatic neuroendocrine tumors and primary hepatic neuroendocrine carcinomas are rare and challenging to diagnose if they are primary to the liver or metastatic. The lack of a uniform definition for primary hepatic neuroendocrine neoplasms hinders understanding and treatment of these rare tumors. This article proposes a multidisciplinary definition and guidelines for diagnosing a neuroendocrine tumor/neuroendocrine carcinomas as being primary to the liver.
Article
Pathology
Gwyneth S. T. Soon, Saba Yasir, Tsung-Teh Wu, Christopher Welle, Sudhakar K. Venkatesh, Michael S. Torbenson, Zongming Eric Chen
Summary: Newer radiotherapy techniques, such as stereotactic body radiation, are increasingly used in the treatment of cholangiocarcinomas, particularly as a bridge to liver transplantation. However, these high-dose therapies result in tissue injury in the peritumoral liver tissue. This retrospective study characterized the morphologic changes in the liver after stereotactic body radiation and found that the changes in the radiated areas were more extensive than in the background liver.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Matthew C. Pope, Michael C. Olson, Kristina T. Flicek, Neema J. Patel, Candice W. Bolan, Christine O. Menias, Zhen Wang, Sudhakar K. Venkatesh
Summary: This study reviewed the imaging findings of chemotherapy-associated liver morphological changes in hepatic metastases (CALMCHeM) on CT/MRI and its association with tumor burden. The results showed that there were significant morphological changes in the liver after chemotherapy, and the severity of the changes was associated with the initial metastatic liver disease burden.
DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jiahui Li, Xin Lu, Zheng Zhu, Kyle J. Kalutkiewicz, Taofic Mounajjed, Terry M. Therneau, Sudhakar K. Venkatesh, Yi Sui, Kevin J. Glaser, Safa Hoodeshenas, Armando Manduca, Vijay H. Shah, Richard L. Ehman, Alina M. Allen, Meng Yin
Summary: This study explored the performance of several magnetic resonance imaging parameters in diagnosing at-risk NASH. Magnetic resonance elastography-assessed liver stiffness (LS) showed the highest accuracy in diagnosing at-risk NASH. Proton density fat fraction (PDFF) had the highest performance in diagnosing NASH with any fibrosis stage.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Marika A. Pitot, Ali D. Tahboub Amawi, Lauren F. Alexander, Jordan D. LeGout, Lara Walkoff, Patrick J. Navin, Akira Kawashima, Adam J. Wood, Angela Dispenzieri, Sudhakar K. Venkatesh
Article
Radiology, Nuclear Medicine & Medical Imaging
Sarah Poetter-Lang, Alina Messner, Nina Bastati, Kristina I. Ringe, Maxime Ronot, Sudhakar K. Venkatesh, Raphael Ambros, Antonia Kristic, Aida Korajac, Gregor Dovjak, Martin Zalaudek, Jacqueline. C. Hodge, Christoph Schramm, Emina Halilbasic, Michael Trauner, Ahmed Ba-Ssalamah
Summary: T1-MRC was found to be superior to T2-MRCP in diagnosing and locating strictures, as well as predicting prognosis in patients with primary sclerosing cholangitis.
EUROPEAN RADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Matthew A. Morgan, Rachita Khot, Karthik M. Sundaram, Daniel R. Ludwig, Rashmi T. Nair, Pardeep K. Mittal, Dhakshina M. Ganeshan, Sudhakar K. Venkatesh
Summary: Primary sclerosing cholangitis is a chronic disease that affects the bile ducts, leading to various complications. Imaging plays a crucial role in diagnosis and treatment.
ABDOMINAL RADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Christopher L. Welle, Patrick J. Navin, Michael C. Olson, Safa Hoodeshenas, Michael S. Torbenson, Sudhakar K. Venkatesh
Summary: Primary sclerosing cholangitis is a chronic liver disease without effective medical treatment, and liver fibrosis is a crucial factor in patient outcome. Magnetic resonance elastography is an accurate non-invasive method for assessing liver fibrosis and is particularly important in evaluating PSC patients.
ABDOMINAL RADIOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Navine Nasser-Ghodsi, Charles B. Rosen, Christopher Welle, Sudhakar K. Venkatesh, Isabella Zaniletti, Walter Kremers, Julie Heimbach, Timucin Taner, Sumera I. Ilyas, Gregory J. Gores, John E. Eaton
Article
Radiology, Nuclear Medicine & Medical Imaging
Temel Tirkes, Dhiraj Yadav, Darwin L. Conwell, Paul R. Territo, Xuandong Zhao, Scott A. Persohn, Anil K. Dasyam, Zarine K. Shah, Sudhakar K. Venkatesh, Naoki Takahashi, Ashley Wachsman, Liang Li, Yan Li, Stephen J. Pandol, Walter G. Park, Santhi S. Vege, Phil A. Hart, Mark Topazian, Dana K. Andersen, Evan L. Fogel
Summary: This study demonstrates that quantitative MRI techniques can be helpful in evaluating chronic pancreatitis. Parameters such as T1 relaxation time, extracellular volume (ECV) fraction, and pancreatic fat signal fraction show good diagnostic performance for chronic pancreatitis. Combining these parameters into a quantitative MRI score (Q-MRI) further improves the diagnostic accuracy.
ABDOMINAL RADIOLOGY
(2022)