Nerve Growth Factor Signaling and Its Contribution to Pain

Nerve-growth-factor antibody for the treatment of osteoarthritis pain and chronic low back pain

(2019) Martin Schmelz et al.   PAIN

Effect of Tanezumab on Joint Pain, Physical Function, and Patient Global Assessment of Osteoarthritis Among Patients With Osteoarthritis of the Hip or Knee

(2019) Thomas J. Schnitzer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Efficacy and safety of intra-articular injection of tropomyosin receptor kinase A inhibitor in painful knee osteoarthritis: a randomized, double-blind and placebo-controlled study

(2019) E. Krupka et al.   OSTEOARTHRITIS AND CARTILAGE

Tropomyosin-related Kinase A (TrkA) Inhibition for the Treatment of Painful Knee Osteoarthritis: Results From a Randomized Controlled Phase 2a Trial

(2019) Fiona Watt et al.   OSTEOARTHRITIS AND CARTILAGE

UVB- and NGF-induced cutaneous sensitization in humans selectively augments cowhage- and histamine-induced pain and evokes mechanical hyperknesis

(2018) Hjalte H. Andersen et al.   EXPERIMENTAL DERMATOLOGY

What is new in pain modification in osteoarthritis?

(2018) Rachel E Miller et al.   RHEUMATOLOGY

Safety and efficacy of subcutaneous tanezumab in patients with knee or hip osteoarthritis

(2018) Charles Birbara et al.   Journal of Pain Research

Experimental Muscle Hyperalgesia Modulates Sensorimotor Cortical Excitability, Which is Partially Altered by Unaccustomed Exercise

(2018) Enrico De Martino et al.   PAIN

ENLARGED AREAS OF PAIN AND PRESSURE HYPERSENSITIVITY BY SPATIALLY DISTRIBUTED INTRAMUSCULAR INJECTIONS OF LOW-DOSE NERVE GROWTH FACTOR

(2018) L. B Sørensen et al.   JOURNAL OF PAIN

Nerve growth factor locally sensitizes nociceptors in human skin

(2017) Otilia Obreja et al.   PAIN

Peripheral inflammatory pain sensitisation is independent of mast cell activation in male mice

(2017) Douglas M. Lopes et al.   PAIN

Characterizing nerve growth factor–p75NTR interactions and small molecule inhibition using surface plasmon resonance spectroscopy

(2016) Kristen S.A. Sheffield et al.   ANALYTICAL BIOCHEMISTRY

Nerve growth factor inhibition with tanezumab influences weight-bearing and subsequent cartilage damage in the rat medial meniscal tear model

(2016) Timothy P LaBranche et al.   ANNALS OF THE RHEUMATIC DISEASES

The interaction between NGF-induced hyperalgesia and acid-provoked pain in the infrapatellar fat pad and tibialis anterior muscle of healthy volunteers

(2016) T.K. Munkholm et al.   EUROPEAN JOURNAL OF PAIN

Effects of Prolonged and Acute Muscle Pain on the Force Control Strategy During Isometric Contractions

(2016) Christian A. Mista et al.   JOURNAL OF PAIN

Tanezumab Reduces Pain in Women with Interstitial Cystitis/Bladder Pain Syndrome and Patients with Nonurological Associated Somatic Syndromes

(2016) J. Curtis Nickel et al.   JOURNAL OF UROLOGY

Using surface plasmon resonance spectroscopy to characterize the inhibition of NGF-p75NTR and proNGF-p75NTR interactions by small molecule inhibitors

(2016) Kristen S.A. Sheffield et al.   PHARMACOLOGICAL RESEARCH

Anti-nerve growth factor in pain management: current evidence

(2016) Steven P. Cohen et al.   Journal of Pain Research

Interaction between ultraviolet B-induced cutaneous hyperalgesia and nerve growth factor-induced muscle hyperalgesia

(2015) S. Lo Vecchio et al.   EUROPEAN JOURNAL OF PAIN

Long-term analgesic effect of a single dose of anti-NGF antibody on pain during motion without notable suppression of joint edema and lesion in a rat model of osteoarthritis

(2015) G. Ishikawa et al.   OSTEOARTHRITIS AND CARTILAGE

Nerve growth factor–induced synapse-like structures in contralateral sensory ganglia contribute to chronic mirror-image pain

(2015) Chau-Fu Cheng et al.   PAIN

Efficacy and safety of tanezumab monotherapy or combined with non-steroidal anti-inflammatory drugs in the treatment of knee or hip osteoarthritis pain

(2014) Thomas J Schnitzer et al.   ANNALS OF THE RHEUMATIC DISEASES

Differential time course of NGF-induced hyperalgesia to heat versus mechanical and electrical stimulation in human skin

(2014) B. Weinkauf et al.   EUROPEAN JOURNAL OF PAIN

Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?

(2014) Jo Nijs et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Functional distinction between NGF-mediated plasticity and regeneration of nociceptive axons within the spinal cord

(2014) C.-L. Lin et al.   NEUROSCIENCE

NGF-induced mechanical sensitization of the masseter muscle is mediated through peripheral NMDA receptors

(2014) H. Wong et al.   NEUROSCIENCE

Fasinumab (REGN475), an antibody against nerve growth factor for the treatment of pain: Results from a double-blind, placebo-controlled exploratory study in osteoarthritis of the knee

(2014) Paul J. Tiseo et al.   PAIN

Increase of nerve growth factor levels in the human herniated intervertebral disc: can annular rupture trigger discogenic back pain?

(2014) Yasuchika Aoki et al.   ARTHRITIS RESEARCH & THERAPY

Intradermal Injection with Nerve Growth Factor: A Reproducible Model to Induce Experimental Allodynia and Hyperalgesia

(2014) Trine Andresen et al.   Pain Practice

Fasinumab (REGN475), an antinerve growth factor monoclonal antibody, for the treatment of acute sciatic pain: results of a proof-of-concept study

(2014) Linda Williams et al.   Journal of Pain Research

Efficacy and safety of tanezumab added on to diclofenac sustained release in patients with knee or hip osteoarthritis: a double-blind, placebo-controlled, parallel-group, multicentre phase III randomised clinical trial

(2013) Andra Rodica Balanescu et al.   ANNALS OF THE RHEUMATIC DISEASES

Tanezumab Reduces Osteoarthritic Hip Pain: Results of a Randomized, Double-Blind, Placebo-Controlled Phase III Trial

(2013) Mark T. Brown et al.   ARTHRITIS AND RHEUMATISM

The role of histamine in neurogenic inflammation

(2013) A C Rosa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Axonal hyperexcitability after combined NGF sensitization and UV-B inflammation in humans

(2013) R. Rukwied et al.   EUROPEAN JOURNAL OF PAIN

Sympathetic Fiber Sprouting in Inflamed Joints and Adjacent Skin Contributes to Pain-Related Behavior in Arthritis

(2013) G. Longo et al.   JOURNAL OF NEUROSCIENCE

Peripheral contribution of NGF and ASIC1a to colonic hypersensitivity in a rat model of irritable bowel syndrome

(2013) J. Matricon et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The p75NTR signaling cascade mediates mechanical hyperalgesia induced by nerve growth factor injected into the rat hind paw

(2013) A. Khodorova et al.   NEUROSCIENCE

Repeated intramuscular injections of nerve growth factor induced progressive muscle hyperalgesia, facilitated temporal summation, and expanded pain areas

(2013) Koei Hayashi et al.   PAIN

Inflammation meets sensitization—an explanation for spontaneous nociceptor activity?

(2013) Roman Rukwied et al.   PAIN

A phase III placebo- and oxycodone-controlled study of tanezumab in adults with osteoarthritis pain of the hip or knee

(2013) Egilius L.H. Spierings et al.   PAIN

Nerve growth factor induces sensitization of nociceptors without evidence for increased intraepidermal nerve fiber density

(2013) Michael Hirth et al.   PAIN

Efficacy and safety of tanezumab versus naproxen in the treatment of chronic low back pain

(2013) Alan J. Kivitz et al.   PAIN

Increased Pro-Inflammatory Cytokines, C-Reactive Protein and Nerve Growth Factor Expressions in Serum of Patients with Interstitial Cystitis/Bladder Pain Syndrome

(2013) Yuan-Hong Jiang et al.   PLoS One

Neuroplasticity of sensory and sympathetic nerve fibers in a mouse model of a painful arthritic joint

(2012) Joseph R. Ghilardi et al.   ARTHRITIS AND RHEUMATISM

Tanezumab Reduces Osteoarthritic Knee Pain: Results of a Randomized, Double-Blind, Placebo-Controlled Phase III Trial

(2012) Mark T. Brown et al.   JOURNAL OF PAIN

NGF-evoked sensitization of muscle fascia nociceptors in humans

(2012) Saskia Deising et al.   PAIN

Sensory and sympathetic nerve fibers undergo sprouting and neuroma formation in the painful arthritic joint of geriatric mice

(2012) Juan M Jimenez-Andrade et al.   ARTHRITIS RESEARCH & THERAPY

NGF, Brain and Behavioral Plasticity

(2012) Alessandra Berry et al.   NEURAL PLASTICITY

Antagonism of Nerve Growth Factor-TrkA Signaling and the Relief of Pain

(2011) Patrick W. Mantyh et al.   ANESTHESIOLOGY

Differential effects of lidocaine on nerve growth factor (NGF)-evoked heat- and mechanical hyperalgesia in humans

(2011) B. Weinkauf et al.   EUROPEAN JOURNAL OF PAIN

Dose and duration of nerve growth factor (NGF) administration determine the extent of behavioral recovery following peripheral nerve injury in the rat

(2011) Stephen W.P. Kemp et al.   EXPERIMENTAL NEUROLOGY

Breast Cancer-Induced Bone Remodeling, Skeletal Pain, and Sprouting of Sensory Nerve Fibers

(2011) Aaron P. Bloom et al.   JOURNAL OF PAIN

NGF enhances electrically induced pain, but not axon reflex sweating

(2011) Otilia Obreja et al.   PAIN

Nerve growth factor selectively decreases activity-dependent conduction slowing in mechano-insensitive C-nociceptors

(2011) Otilia Obreja et al.   PAIN

Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer pain

(2011) Juan Miguel Jimenez-Andrade et al.   PAIN

Taking Pain Out of NGF: A “Painless” NGF Mutant, Linked to Hereditary Sensory Autonomic Neuropathy Type V, with Full Neurotrophic Activity

(2011) Simona Capsoni et al.   PLoS One

Nerve growth factor level in the prostatic fluid of patients with chronic prostatitis/chronic pelvic pain syndrome is correlated with symptom severity and response to treatment

(2010) Toyohiko Watanabe et al.   BJU INTERNATIONAL

Local Pain and Spreading Hyperalgesia Induced by Intramuscular Injection of Nerve Growth Factor Are Not Reduced by Local Anesthesia of the Muscle

(2010) Renate Karin Herren Gerber et al.   CLINICAL JOURNAL OF PAIN

The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling

(2010) C. Ceni et al.   JOURNAL OF CELL SCIENCE

A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy

(2010) O. P. Carvalho et al.   JOURNAL OF MEDICAL GENETICS

ERK1/2 Mitogen-Activated Protein Kinase Phosphorylates Sodium Channel Nav1.7 and Alters Its Gating Properties

(2010) S. Stamboulian et al.   JOURNAL OF NEUROSCIENCE

Pathological Sprouting of Adult Nociceptors in Chronic Prostate Cancer-Induced Bone Pain

(2010) J. M. Jimenez-Andrade et al.   JOURNAL OF NEUROSCIENCE

Long-Distance Control of Synapse Assembly by Target-Derived NGF

(2010) Nikhil Sharma et al.   NEURON

Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain

(2010) W.G. Mantyh et al.   NEUROSCIENCE

Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis

(2010) D. A. Walsh et al.   RHEUMATOLOGY

Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function

(2009) Birthe Schnegelsberg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Urinary nerve growth factor level is increased in patients with interstitial cystitis/bladder pain syndrome and decreased in responders to treatment

(2009) Hsin-Tzu Liu et al.   BJU INTERNATIONAL

Role of interleukin-1β during pain and inflammation

(2009) Ke Ren et al.   BRAIN RESEARCH REVIEWS

Differential contribution of SNARE-dependent exocytosis to inflammatory potentiation of TRPV1 in nociceptors

(2009) M. Camprubí-Robles et al.   FASEB JOURNAL

NGF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skin

(2009) Roman Rukwied et al.   PAIN

Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc

(2009) Stephen M Richardson et al.   ARTHRITIS RESEARCH & THERAPY

Facilitated neurotrophin release in sensitized human skin

(2008) Sarah Paterson et al.   EUROPEAN JOURNAL OF PAIN

Temporal summation of pressure pain during muscle hyperalgesia evoked by nerve growth factor and eccentric contractions

(2008) Hongling Nie et al.   EUROPEAN JOURNAL OF PAIN

HUMAN PRONGF: BIOLOGICAL EFFECTS AND BINDING PROFILES AT TRKA, P75NTRAND SORTILIN

(2008) Oliver Clewes et al.   JOURNAL OF NEUROCHEMISTRY

Phosphorylation of Sodium Channel Nav1.8 by p38 Mitogen-Activated Protein Kinase Increases Current Density in Dorsal Root Ganglion Neurons

(2008) A. Hudmon et al.   JOURNAL OF NEUROSCIENCE

Brain-derived neurotrophic factor enhances the excitability of rat sensory neurons through activation of the p75 neurotrophin receptor and the sphingomyelin pathway

(2008) Y. H. Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Molecular Mechanisms of Sensitization of Pain-transducing P2X3 Receptors by the Migraine Mediators CGRP and NGF

(2008) Rashid Giniatullin et al.   MOLECULAR NEUROBIOLOGY

Histamine-Induced Itch and its Relationship with Pain

(2008) Won-Sik Shim et al.   Molecular Pain

Nerve growth factor R221W responsible for insensitivity to pain is defectively processed and accumulates as proNGF

(2008) Elin Larsson et al.   NEUROBIOLOGY OF DISEASE

Mast Cell-Derived Histamine Mediates Cystitis Pain

(2008) Charles N. Rudick et al.   PLoS One

Effects of NGF-induced muscle sensitization on proprioception and nociception

(2008) Peter Svensson et al.   EXPERIMENTAL BRAIN RESEARCH

Spatial and temporal aspects of muscle hyperalgesia induced by nerve growth factor in humans

(2008) Helle Andersen et al.   EXPERIMENTAL BRAIN RESEARCH