Tissue Engineering and Biomaterial Strategies to Elicit Endogenous Neuronal Replacement in the Brain

Single-cell analysis of olfactory neurogenesis and differentiation in adult humans

(2020) Michael A. Durante et al.   NATURE NEUROSCIENCE

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

(2019) Elena P. Moreno-Jiménez et al.   NATURE MEDICINE

Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain

(2019) Kirsten Obernier et al.   DEVELOPMENT

Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients

(2019) Matthew K. Tobin et al.   Cell Stem Cell

Adult Neurogenesis in the Subventricular Zone and Its Regulation After Ischemic Stroke: Implications for Therapeutic Approaches

(2019) Yörg Dillen et al.   Translational Stroke Research

Perspective: Of Mice and Men – How Widespread Is Adult Neurogenesis?

(2019) David Petrik et al.   Frontiers in Neuroscience

Lineage Tracing and Cell Potential of Postnatal Single Progenitor Cells In Vivo

(2019) María Figueres-Oñate et al.   Stem Cell Reports

Migration and Differentiation of Neural Stem Cells Diverted From the Subventricular Zone by an Injectable Self-Assembling β-Peptide Hydrogel

(2019) Sepideh Motamed et al.   Frontiers in Bioengineering and Biotechnology

Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury

(2018) Hideo Jinnou et al.   Cell Stem Cell

Human Hippocampal Neurogenesis Persists throughout Aging

(2018) Maura Boldrini et al.   Cell Stem Cell

Human Adult Neurogenesis: Evidence and Remaining Questions

(2018) Gerd Kempermann et al.   Cell Stem Cell

Adult Neurogenesis Is Sustained by Symmetric Self-Renewal and Differentiation

(2018) Kirsten Obernier et al.   Cell Stem Cell

Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer’s Disease Adults

(2018) Sara Cipriani et al.   CEREBRAL CORTEX

Adult neurogenesis and its role in brain injury and psychiatric diseases

(2018) Yoshitaka Hayashi et al.   JOURNAL OF NEUROCHEMISTRY

Tissue engineered nigrostriatal pathway for treatment of Parkinson's disease

(2018) Laura A. Struzyna et al.   Journal of Tissue Engineering and Regenerative Medicine

In vivo migration of endogenous brain progenitor cells guided by an injectable peptide amphiphile biomaterial

(2018) Reza Motalleb et al.   Journal of Tissue Engineering and Regenerative Medicine

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

(2018) Shawn F. Sorrells et al.   NATURE

Live imaging of neurogenesis in the adult mouse hippocampus

(2018) Gregor-Alexander Pilz et al.   SCIENCE

Redirection of neuroblast migration from the rostral migratory stream into a lesion in the prefrontal cortex of adult rats

(2018) Jannis Gundelach et al.   EXPERIMENTAL BRAIN RESEARCH

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

(2018) Kritika S. Katiyar et al.   Jove-Journal of Visualized Experiments

Neural stem cell spacing questions their self-renewal

(2018) Olga Mineyeva et al.   Aging-US

Preconditioning and Cellular Engineering to Increase the Survival of Transplanted Neural Stem Cells for Motor Neuron Disease Therapy

(2018) Elena Abati et al.   MOLECULAR NEUROBIOLOGY

New approaches for brain repair—from rescue to reprogramming

(2018) Roger A. Barker et al.   NATURE

A tissue-engineered rostral migratory stream for directed neuronal replacement

(2018) DKacy Cullen et al.   Neural Regeneration Research

Specific inhibition of ADAM17/TACE promotes neurogenesis in the injured motor cortex

(2018) Noelia Geribaldi-Doldán et al.   Cell Death & Disease

A new function for Prokineticin 2: Recruitment of SVZ-derived neuroblasts to the injured cortex in a mouse model of traumatic brain injury

(2018) Mayara Vieira Mundim et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration

(2018) N. Kaneko et al.   Science Advances

Mechanisms of neuronal migration in the adult brain

(2017) Naoko Kaneko et al.   JOURNAL OF NEUROCHEMISTRY

Clinical tests of neurotrophic factors for human neurodegenerative diseases, part 2: Where do we stand and where must we go next?

(2017) Raymond T. Bartus et al.   NEUROBIOLOGY OF DISEASE

Clinical tests of neurotrophic factors for human neurodegenerative diseases, part 1: Where have we been and what have we learned?

(2017) Raymond T. Bartus et al.   NEUROBIOLOGY OF DISEASE

The therapeutic potential of cell identity reprogramming for the treatment of aging-related neurodegenerative disorders

(2017) Derek K. Smith et al.   PROGRESS IN NEUROBIOLOGY

Eminent Sources of Adult Mesenchymal Stem Cells and Their Therapeutic Imminence

(2017) Dannie Macrin et al.   Stem Cell Reviews and Reports

Alzheimer’s disease, dementia, and stem cell therapy

(2017) Thomas Duncan et al.   Stem Cell Research & Therapy

Eminent Sources of Adult Mesenchymal Stem Cells and Their Therapeutic Imminence

(2017) Dannie Macrin et al.   Stem Cell Reviews and Reports

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

(2017) Laura A. Struzyna et al.   Jove-Journal of Visualized Experiments

β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain

(2017) Teppei Fujioka et al.   EBioMedicine

Transplantable living scaffolds comprised of micro-tissue engineered aligned astrocyte networks to facilitate central nervous system regeneration

(2016) Carla C. Winter et al.   Acta Biomaterialia

Neurogenesis and Gliogenesis in Nervous System Plasticity and Repair

(2016) Jonas Frisén   Annual Review of Cell and Developmental Biology

Adult Neurogenesis in Mammals: Variations and Confusions

(2016) Hans-Peter Lipp et al.   BRAIN BEHAVIOR AND EVOLUTION

Nanobiomaterials’ applications in neurodegenerative diseases

(2016) Daniela Silva Adaya et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Advanced biomaterial strategies to transplant preformed micro-tissue engineered neural networks into the brain

(2016) J P Harris et al.   Journal of Neural Engineering

Direct Conversion of Somatic Cells into Induced Neurons

(2016) Na An et al.   MOLECULAR NEUROBIOLOGY

In Vivo Reprogramming for CNS Repair: Regenerating Neurons from Endogenous Glial Cells

(2016) Hedong Li et al.   NEURON

In Vivo Neural Tissue Engineering: Cylindrical Biocompatible Hydrogels That Create New Neural Tracts in the Adult Mammalian Brain

(2016) Amanda R. Clark et al.   STEM CELLS AND DEVELOPMENT

Neuronal Circuitry Mechanisms Regulating Adult Mammalian Neurogenesis

(2016) Juan Song et al.   Cold Spring Harbor Perspectives in Biology

The Adult Ventricular–Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis

(2016) Daniel A. Lim et al.   Cold Spring Harbor Perspectives in Biology

Biomaterials for Enhancing CNS Repair

(2016) Teck Chuan Lim et al.   Translational Stroke Research

Directing immunomodulation using biomaterials for endogenous regeneration

(2016) Yang Yu et al.   Journal of Materials Chemistry B

Graphene Functionalized Scaffolds Reduce the Inflammatory Response and Supports Endogenous Neuroblast Migration when Implanted in the Adult Brain

(2016) Kun Zhou et al.   PLoS One

Neural and glial progenitor transplantation as a neuroprotective strategy for Amyotrophic Lateral Sclerosis (ALS)

(2015) Amanda M. Haidet-Phillips et al.   BRAIN RESEARCH

Novel subventricular zone early progenitor cell-specific adenovirus for in vivo therapy of central nervous system disorders reinforces brain stem cell heterogeneity

(2015) Julia Reetz et al.   Brain Structure & Function

Heart Disease and Stroke Statistics—2016 Update

(2015) Dariush Mozaffarian et al.   CIRCULATION

Brain size and limits to adult neurogenesis

(2015) Mercedes F. Paredes et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Thinner Medial Temporal Cortex in Adolescents With Attention-Deficit/Hyperactivity Disorder and the Effects of Stimulants

(2015) Lizanne J.S. Schweren et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Longitudinal Cortical Development During Adolescence and Young Adulthood in Autism Spectrum Disorder: Increased Cortical Thinning but Comparable Surface Area Changes

(2015) Gregory L. Wallace et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Global neurotrauma research challenges and opportunities

(2015) Andrés M. Rubiano et al.   NATURE

Restoring nervous system structure and function using tissue engineered living scaffolds

(2015) DKacy Cullen et al.   Neural Regeneration Research

Enhancement of Neuroblast Migration into the Injured Cerebral Cortex Using Laminin-Containing Porous Sponge

(2015) Itsuki Ajioka et al.   TISSUE ENGINEERING PART A

Rebuilding Brain Circuitry with Living Micro-Tissue Engineered Neural Networks

(2015) Laura A. Struzyna et al.   TISSUE ENGINEERING PART A

Neurogenesis following Stroke Affecting the Adult Brain

(2015) Olle Lindvall et al.   Cold Spring Harbor Perspectives in Biology

Noncanonical Sites of Adult Neurogenesis in the Mammalian Brain

(2015) David M. Feliciano et al.   Cold Spring Harbor Perspectives in Biology

Adult Neurogenesis in Humans

(2015) Olaf Bergmann et al.   Cold Spring Harbor Perspectives in Biology

Neurogenesis in the Adult Hippocampus

(2015) Gerd Kempermann et al.   Cold Spring Harbor Perspectives in Biology

Mechanisms and Functional Significance of Stroke-Induced Neurogenesis

(2015) Quentin Marlier et al.   Frontiers in Neuroscience

Reduction in Subventricular Zone-Derived Olfactory Bulb Neurogenesis in a Rat Model of Huntington’s Disease Is Accompanied by Striatal Invasion of Neuroblasts

(2015) Mahesh Kandasamy et al.   PLoS One

Comparison of Cortical and White Matter Traumatic Brain Injury Models Reveals Differential Effects in the Subventricular Zone and Divergent Sonic Hedgehog Signaling Pathways in Neuroblasts and Oligodendrocyte Progenitors

(2014) Amanda J. Mierzwa et al.   ASN Neuro

Nanofibrous scaffolds releasing a small molecule BDNF-mimetic for the re-direction of endogenous neuroblast migration in the brain

(2014) Deniece Fon et al.   BIOMATERIALS

Hypomyelination with atrophy of the basal ganglia and cerebellum: further delineation of the phenotype and genotype–phenotype correlation

(2014) Eline M. Hamilton et al.   BRAIN

Neurogenesis in the Striatum of the Adult Human Brain

(2014) Aurélie Ernst et al.   CELL

Living scaffolds for neuroregeneration

(2014) Laura A. Struzyna et al.   CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE

How to make a hippocampal dentate gyrus granule neuron

(2014) D. X. Yu et al.   DEVELOPMENT

Adult neurogenesis: mechanisms and functional significance

(2014) S. M. G. Braun et al.   DEVELOPMENT

Distinct patterns of cortical thinning in concurrent motor and attention disorders

(2014) Lisa Marie Langevin et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Neurogenesis during development of the vertebrate central nervous system

(2014) J. T. Paridaen et al.   EMBO REPORTS

Endogenous neurogenesis following ischaemic brain injury: Insights for therapeutic strategies

(2014) Tobias D. Merson et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Mechanics of Traumatic Brain Injury: A Review of What We Know and What We Need to Know for Reducing Its Societal Burden

(2014) David F. Meaney et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Human and Monkey Striatal Interneurons Are Derived from the Medial Ganglionic Eminence But Not from the Adult Subventricular Zone

(2014) C. Wang et al.   JOURNAL OF NEUROSCIENCE

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse

(2014) J. P. Magnusson et al.   SCIENCE

Effects of GDNF-Loaded Injectable Gelatin-Based Hydrogels on Endogenous Neural Progenitor Cell Migration

(2014) Deniece Fon et al.   Advanced Healthcare Materials

Major unsolved points in adult neurogenesis: doors open on a translational future?

(2014) Paolo Peretto et al.   Frontiers in Neuroscience

Neurotransmitter-mediated control of neurogenesis in the adult vertebrate brain

(2013) D. A. Berg et al.   DEVELOPMENT

Parkinson disease: from pathology to molecular disease mechanisms

(2013) David T. Dexter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regenerative Therapies for Central Nervous System Diseases: a Biomaterials Approach

(2013) Roger Y Tam et al.   NEUROPSYCHOPHARMACOLOGY

Immunopharmacological intervention for successful neural stem cell therapy: New perspectives in CNS neurogenesis and repair

(2013) Dearbhaile Dooley et al.   PHARMACOLOGY & THERAPEUTICS

Long-Term Upregulation of Inflammation and Suppression of Cell Proliferation in the Brain of Adult Rats Exposed to Traumatic Brain Injury Using the Controlled Cortical Impact Model

(2013) Sandra A. Acosta et al.   PLoS One

Brain-Derived Neurotrophic Factor Promotes Vasculature-Associated Migration of Neuronal Precursors toward the Ischemic Striatum

(2013) Sofia Grade et al.   PLoS One

Cell cycle and lineage progression of neural progenitors in the ventricular-subventricular zones of adult mice

(2013) Giovanna Ponti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Updated Definition of Stroke for the 21st Century

(2013) Ralph L. Sacco et al.   STROKE

Hydrogel delivery of erythropoietin to the brain for endogenous stem cell stimulation after stroke injury

(2012) Yuanfei Wang et al.   BIOMATERIALS

Adult Neural Stem Cells Bridge Their Niche

(2012) Luis C. Fuentealba et al.   Cell Stem Cell

Neural Stem Cells and Neurogenesis in the Adult

(2012) Christian Göritz et al.   Cell Stem Cell

Adult neural stem cells: an endogenous tool to repair brain injury?

(2012) Gian Carlo Bellenchi et al.   JOURNAL OF NEUROCHEMISTRY

Nanotechnology for neurodegenerative disorders

(2012) Francesca Re et al.   MATURITAS

Microtissue Engineered Constructs with Living Axons for Targeted Nervous System Reconstruction

(2012) D. Kacy Cullen et al.   TISSUE ENGINEERING PART A

Bilateral Transplantation of Allogenic Adult Human Bone Marrow-Derived Mesenchymal Stem Cells into the Subventricular Zone of Parkinson’s Disease: A Pilot Clinical Study

(2012) N. K. Venkataramana et al.   Stem Cells International

Growth Factors Released from Gelatin Hydrogel Microspheres Increase New Neurons in the Adult Mouse Brain

(2012) Kanako Nakaguchi et al.   Stem Cells International

Acute ischemic stroke in children versus young adults

(2011) Sandra Bigi et al.   ANNALS OF NEUROLOGY

Controlled epi-cortical delivery of epidermal growth factor for the stimulation of endogenous neural stem cell proliferation in stroke-injured brain

(2011) Michael J. Cooke et al.   BIOMATERIALS

Adult hippocampal neurogenesis and related neurotrophic factors

(2011) Eu-Gene Lee et al.   BMB Reports

Cell-intrinsic signals that regulate adult neurogenesis in vivo: insights from inducible approaches

(2011) Madeleine A. Johnson et al.   BMB Reports

The proliferative capacity of the subventricular zone is maintained in the parkinsonian brain

(2011) Simone A. van den Berge et al.   BRAIN

In Vivo Clonal Analysis Reveals Self-Renewing and Multipotent Adult Neural Stem Cell Characteristics

(2011) Michael A. Bonaguidi et al.   CELL

Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain

(2011) Congmin Wang et al.   CELL RESEARCH

Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus

(2011) Juan M. Encinas et al.   Cell Stem Cell

Adult neurogenesis in mammals - a theme with many variations

(2011) Luca Bonfanti et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Overcoming Endogenous Constraints on Neuronal Regeneration

(2011) N Mokarram et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Cortical Gray Matter in Attention-Deficit/Hyperactivity Disorder: A Structural Magnetic Resonance Imaging Study

(2011) Martin J. Batty et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

Interleukin-15 regulates proliferation and self-renewal of adult neural stem cells

(2011) Diego Gómez-Nicola et al.   MOLECULAR BIOLOGY OF THE CELL

Corridors of migrating neurons in the human brain and their decline during infancy

(2011) Nader Sanai et al.   NATURE

Developmental cortical thinning in fetal alcohol spectrum disorders

(2011) Dongming Zhou et al.   NEUROIMAGE

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

(2011) Guo-li Ming et al.   NEURON

ADAM-17/Tumor Necrosis Factor-α-Converting Enzyme Inhibits Neurogenesis and Promotes Gliogenesis from Neural Stem Cells

(2011) Carmen Romero-Grimaldi et al.   STEM CELLS

Biomaterials for Brain Tissue Engineering

(2010) Jerani T. S. Pettikiriarachchi et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Age-related temporal and parietal cortical thinning in autism spectrum disorders

(2010) Gregory L. Wallace et al.   BRAIN

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

(2010) Wei Deng et al.   NATURE REVIEWS NEUROSCIENCE

New Neurons Clear the Path of Astrocytic Processes for Their Rapid Migration in the Adult Brain

(2010) Naoko Kaneko et al.   NEURON

Mesenchymal Stem Cells Stimulate Endogenous Neurogenesis in the Subventricular Zone of Adult Mice

(2010) Inna Kan et al.   Stem Cell Reviews and Reports

Subventricular Zone-Derived Neural Progenitor Cells Migrate Along a Blood Vessel Scaffold Toward the Post-Stroke Striatum

(2010) Takuro Kojima et al.   STEM CELLS

Effects of Granulocyte-Colony Stimulating Factor After Stroke in Aged Rats

(2010) Aurel Popa-Wagner et al.   STROKE

Is adult neurogenesis essential for olfaction?

(2010) Françoise Lazarini et al.   TRENDS IN NEUROSCIENCES

Targeted nonviral delivery vehicles to neural progenitor cells in the mouse subventricular zone

(2009) Ester J. Kwon et al.   BIOMATERIALS

Frontal and temporal volumes in Childhood Absence Epilepsy

(2009) Rochelle Caplan et al.   EPILEPSIA

Patterns and Dynamics of Subventricular Zone Neuroblast Migration in the Ischemic Striatum of the Adult Mouse

(2009) Rui L Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Biomaterials for promoting brain protection, repair and regeneration

(2009) Gorka Orive et al.   NATURE REVIEWS NEUROSCIENCE

Forebrain neurogenesis after focal Ischemic and traumatic brain injury

(2009) Steven G. Kernie et al.   NEUROBIOLOGY OF DISEASE

From Neurotransmitters to Neurotrophic Factors to Neurogenesis

(2009) Theo Hagg   NEUROSCIENTIST

Adult Mouse Subventricular Zone Stem and Progenitor Cells Are Sessile and Epidermal Growth Factor Receptor Negatively Regulates Neuroblast Migration

(2009) Yongsoo Kim et al.   PLoS One

Neurogenesis in adult CNS: From denial to opportunities and challenges for therapy

(2008) Luca Colucci-D'Amato et al.   BIOESSAYS

Intranasal delivery of transforming growth factor-beta1 in mice after stroke reduces infarct volume and increases neurogenesis in the subventricular zone

(2008) Minmin Ma et al.   BMC NEUROSCIENCE

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

Gene Profiles and Electrophysiology of Doublecortin-Expressing Cells in the Subventricular Zone after Ischemic Stroke

(2008) Xian Shuang Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Biomaterials for the central nervous system

(2008) Y. Zhong et al.   Journal of the Royal Society Interface

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Neurons born in the adult dentate gyrus form functional synapses with target cells

(2008) Nicolas Toni et al.   NATURE NEUROSCIENCE

Thinning of sensorimotor cortices in children with Tourette syndrome

(2008) Elizabeth R Sowell et al.   NATURE NEUROSCIENCE

Therapeutic Strategy for Ischemic Stroke

(2008) Toru Yamashita et al.   NEUROCHEMICAL RESEARCH

Origin and function of olfactory bulb interneuron diversity

(2008) Pierre-Marie Lledo et al.   TRENDS IN NEUROSCIENCES