Article
Immunology
Louise M. Ince, Jeffrey S. Darling, Kevin Sanchez, Kiersten S. Bell, Jennifer K. Melbourne, Lourdes K. Davis, Kimberly Nixon, Andrew D. Gaudet, Laura. K. Fonken
Summary: Aging is associated with changes in immune system reactivity. Male rats show cognitive decline and increased neuroinflammatory responses, while females do not. Sex differences play a crucial role in the mechanism of aging.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Medicine, General & Internal
Lei Pang, Xi Jiang, Xin Lian, Jie Chen, Er-Fei Song, Lei-Gang Jin, Zheng-Yuan Xia, Hai-Chun Ma, Yin Cai
Summary: Graphene, a two-dimensional material composed of a single layer of carbon atoms, is gaining significant attention in the field of electronics due to its excellent conductivity and high chemical stability.
MILITARY MEDICAL RESEARCH
(2022)
Article
Geriatrics & Gerontology
Megan E. Ramaker, David L. Corcoran, Abner T. Apsley, Michael S. Kobor, Virginia B. Kraus, William E. Kraus, David T. S. Lin, Melissa C. Orenduff, Carl F. Pieper, Reem Waziry, Kim M. Huffman, Daniel W. Belsky
Summary: Calorie restriction has been shown to increase healthy lifespan and slow down aging-associated DNA methylation changes. A study conducted in humans found that calorie restriction can alter age-related DNA methylation patterns but no significant changes were observed at individual CpG sites.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Nutrition & Dietetics
Margalida Torrens-Mas, Cayetano Navas-Enamorado, Devin Wahl, Andres Sanchez-Polo, Anna Picca, Jordi Oliver, Pilar Roca, Marta Gonzalez-Freire
Summary: “Calorie restriction (CR) is the only nutritional strategy proven to extend lifespan, prevent age-related diseases, and delay functional decline. The effects of CR when started early in life are not well understood. This study found that young female rats treated with CR showed similar expression patterns of key genes/pathways associated with healthy aging compared to old animals treated with CR, while in male rats these effects were reduced.”
Review
Cell Biology
Jingfang Zhai, William H. H. Kongsberg, Yinbo Pan, Canhua Hao, Xiaojing Wang, Jie Sun
Summary: Research suggests that dietary changes can alter epigenetic marks associated with aging. Caloric restriction (CR) is considered an intervention to regulate aging and prolong lifespan, and has made some progress by regulating aging-related signaling pathways and intercellular signaling molecules. This review focuses on autophagy and epigenetic modifications to elaborate the molecular mechanisms by which CR delays aging by triggering autophagy, epigenetic modifications, and their interaction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nastaran Daneshgar, Peter S. Rabinovitch, Dao-Fu Dai
Summary: mTOR signaling plays a crucial role in regulating cellular metabolism and aging by controlling key cellular processes such as protein synthesis, autophagy, and mitochondrial function. Dysregulation of mTOR signaling has been associated with various age-related pathologies, including heart failure and age-related cardiac dysfunction.
Article
Geriatrics & Gerontology
Masaki Kobayashi, Yuichiro Nezu, Mayu Itoh, Rio Uchida, Tomoya Arikawa, Minami Otsubo, Yuka Nozaki, Ryoma Tagawa, Yuya Fujishima, Norikazu Maeda, Iichiro Shimomura, Yoshikazu Higami
Summary: This study aimed to evaluate the association of aging and caloric restriction (CR) with oligomerization of adiponectin (APN) in rodent models. The results showed that aging increased the levels of high molecular weight complexes (HMW) and middle molecular weight complexes (MMW) in mice, while CR only elevated HMW levels. Furthermore, aging reduced the expression levels of Adipoq mRNA in mice and rats, while CR prevented this reduction only in rats.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Trine B. Opstad, Tine Sundfor, Serena Tonstad, Ingebjorg Seljeflot
Summary: This study found that the effects of 1 year of caloric restriction on Sirtuin1 concentrations are related to sex and BMI, with the intermittent CR regimen affecting Sirtuin1 to a greater extent than continuous CR, suggesting personalized dietary intervention.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Cell Biology
Samuel Abokyi, George Ghartey-Kwansah, Dennis Yan-yin Tse
Summary: Old age is associated with a greater burden of disease, including neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, as well as other chronic diseases. Popular lifestyle interventions and pharmacological interventions can induce transcription factor EB (TFEB) and autophagy, which have a therapeutic impact on aging and age-related diseases. The activation of TFEB holds promise as a safe and effective strategy for treating multiple age-associated diseases and extending lifespan.
AGEING RESEARCH REVIEWS
(2023)
Article
Cell Biology
Alexander M. Wolf
Summary: Understanding the molecular mechanisms of normal aging is crucial for improving human health span. Caloric restriction delays aging, but its benefits depend on the weight status of control mice. Pharmacological interventions that increase lifespan and reduce body weight may not be suitable for healthy weight individuals.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Article
Nutrition & Dietetics
Claudia Tonini, Marco Segatto, Francesca Martino, Luisa Cigliano, Martina Nazzaro, Laura Barberio, Maurizio Mandala, Valentina Pallottini
Summary: The study suggests that caloric restriction in late life can partially reverse some age-related changes studied here, but not all impacts can be completely altered.
Article
Nutrition & Dietetics
Chanisa Thonusin, Patcharapong Pantiya, Aphisek Kongkaew, Wichwara Nawara, Busarin Arunsak, Sirawit Sriwichaiin, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Exercise and caloric restriction have different effects on skeletal muscle metabolism during aging. Exercise is more effective in improving fatty acid oxidation and oxidative phosphorylation, while caloric restriction reduces oxidative stress in skeletal muscle.
Review
Nutrition & Dietetics
Xiujuan Wang, Meihong Xu, Yong Li
Summary: Adipose tissue, as the largest endocrine organ, plays a crucial role in regulating energy balance and immune function. Nutritional interventions have been proven effective in managing adipose tissue aging's adverse effects.
Review
Immunology
Jinming Han, Yueshan Fan, Kai Zhou, Klas Blomgren, Robert A. Harris
Summary: There are inherent structural and functional differences in the central nervous systems of females and males, including sex-specific differences in genetic, epigenetic, and hormonal factors. Microglia, as principal resident macrophages in the CNS, have recently been found to exhibit sex-dependent structural and functional differences, which has implications for the design of sex- and microglia-specific therapeutic approaches for CNS diseases.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Stefanos Ioannis Kaplanis, Despoina Kaffe, Niki Ktena, Andriani Lygeraki, Ourania Kolliniati, Maria Savvaki, Domna Karagogeos
Summary: Caloric restriction, a controlled reduction in calorie intake, is known to have numerous health benefits, including the ability to promote myelin production and remyelination. In this study, the researchers investigated the effect of nicotinamide, a compound that mimics caloric restriction, on myelin production in demyelinating conditions. The results showed that nicotinamide enhanced myelination and remyelination both in vitro and in vivo, and it also reduced inflammation by influencing astrocytes and microglia.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)