Article
Orthopedics
Nusret Kose, Zeynel M. Asfuroglu, Aydan Kose, Varol Sahinturk, Mevlut Gurbuz, Aydin Dogan
Summary: Experimental study demonstrates that silver ion-doped calcium phosphate-based bone graft substitution can stimulate bone growth, combat infection, and effectively treat chronic osteomyelitis in an animal model.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Medicine, General & Internal
Hassan Serrier, Laure Huot, Sophie Brosset, Cecile Batailler, Tristan Ferry
Summary: The study aims to evaluate the cost-effectiveness of using Cerament-G compared to standard of care in the treatment of chronic long bone osteomyelitis. The study is a prospective, multicenter, randomized, single blind study conducted in 14 French Reference Centers for Complex Osteoarticular infections. The results will support the recommendation for the use of Cerament-G and its reimbursement through the French Health Insurance scheme.
FRONTIERS IN MEDICINE
(2023)
Article
Materials Science, Multidisciplinary
A. M. Lopera-Echavarria, Daniela Medrano-David, Angela M. Lema-Perez, Pedronel Araque-Marin, Martha E. Londono
Summary: A new methodology was proposed to evaluate the behavior of bone substitutes in a confined bone environment, assessing their bioactivity, stability, and cytotoxicity. The bone substitute showed bioactivity and apatite formation in simulated body fluid, with a high swelling rate but maintained stability during degradation testing. Cytotoxicity evaluation showed no harmful effects on cells.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Materials Science, Ceramics
Tatiana Padrao, Joana Dias, Angela Carvalho, Marta T. Pinto, Fernando J. Monteiro, Susana R. Sousa
Summary: This study developed lyophilized vancomycin-loaded heparinized nanohydroxyapatite/collagen granules for clinical application, addressing infection eradication and bone regeneration. The local bone substitute delivery system provided an attractive alternative solution not yet commercially available. The lyophilization process effectively controlled the release of antibiotics, inhibiting the growth of MRSA. Additionally, the material promoted osteoblasts activity and induced neovascularization.
CERAMICS INTERNATIONAL
(2023)
Article
Cell & Tissue Engineering
Yongfeng Li, Huawei Liu, Chao Wang, Rongzeng Yan, Lei Xiang, Xiaodan Mu, Lingling Zheng, Changkui Liu, Min Hu
Summary: This study aimed to fabricate 3D-printing titanium grid scaffolds to achieve bone fusion in mandibular segmental defects. The results showed that the scaffolds with sufficient pores and basic biomechanical strength could facilitate bone regeneration and integration of bone broken ends. Clinical observations on both animal models and patients confirmed the successful bone regeneration in mandibular defects using the titanium grid scaffolds.
NPJ REGENERATIVE MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Winston Adam Camargo, Jan Willem Hoekstra, John A. Jansen, Jeroen J. J. P. van den Beucken
Summary: In this study, the effect of alendronate (ALN) treatment on bone defect regeneration in osteoporotic rats was evaluated. The results showed that oral administration of ALN can enhance bone formation in the defects, increasing it to 10 times compared to the non-treated group. Additionally, Bio-Oss(R) was found to be an effective bone substitute, promoting bone formation in both healthy and osteoporotic conditions. The study highlights the beneficial effects of oral ALN in mitigating the adverse effects of osteoporosis on bone defect regeneration.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Shuting Sun, Jianguo Tao, Parish P. Sedghizadeh, Philip Cherian, Adam F. Junka, Esmat Sodagar, Lianping Xing, Robert K. Boeckman, Venkatesan Srinivasan, Zhenqiang Yao, Brendan F. Boyce, Brea Lipe, Jeffrey D. Neighbors, R. Graham G. Russell, Charles E. McKenna, Frank H. Ebetino
Summary: Advancements in designing bone-selective drugs have opened up new possibilities for treating various bone-related diseases. These drugs show promising potential in improving efficacy and safety, especially in addressing bone-related cancers, infections, and osteomyelitis.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Holger Freischmidt, Jonas Armbruster, Catharina Rothhaas, Nadine Titze, Thorsten Guehring, Dennis Nurjadi, Jan Philippe Kretzer, Gerhard Schmidmaier, Paul Alfred Grutzner, Lars Helbig
Summary: This study investigated the osteoinductive, osteoconductive, and anti-infective efficacy of HACaS+G for the treatment of infected non-unions. The results showed that HACaS+G had osteoinductive properties, but did not provide additional benefits in terms of osteoconduction and mechanical bone stability for infected non-unions, especially those with segmental bone defects.
Article
Microbiology
Andrea Sambri, Luca Cevolani, Valentina Passarino, Marta Bortoli, Stefania Claudia Parisi, Michele Fiore, Laura Campanacci, Eric Staals, Davide Maria Donati, Massimiliano De Paolis
Summary: This retrospective study evaluates the treatment of chronic osteomyelitis using local debridement combined with PerOssal(& REG;). A total of 93 patients were included and followed up for a median of 21 months. The primary outcome was the eradication of infection, and 22.6% of patients developed an infection recurrence after a median follow-up of 11 months. PerOssal(& REG;) has practical advantages due to its good biocompatibility and sufficient antibiotic release.
Review
Engineering, Biomedical
Bharti Bisht, Ashley Hope, Anubhab Mukherjee, Manash K. Paul
Summary: The demand for bone grafts is high and complex, with traditional substitutes facing limitations, but the development of 3D printing technology is creating optimism for repairing bone trauma and defects in the future.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Materials Science, Multidisciplinary
Wentao Shi, Yunduan Que, Xuan Zhang, Lu Bian, Xuejian Yu, Xue Tang, Guofeng Yang, Yao Dai, Shiqi Bi, Demin Lv, Yuyan Weng, Weijiang Wu, Zhijian Zhang, Xiaojie Lu, Naiyan Lu
Summary: The study developed a novel biofunctional live tissue-engineered bone-like graft, demonstrating that overexpression of TG2 by stem cells promoted osteogenic differentiation and improved bone regeneration for bone defect repair.
NPG ASIA MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Cristiana Griffoni, Giuseppe Tedesco, Valentina Canella, Angelo Nataloni, Alberto Zerbi, Giovanni Tosini, Alessandro Gasbarrini, Giovanni Barbanti-Brodano
Summary: The study demonstrates the effectiveness and safety profile of an Mg-doped hydroxyapatite bone graft substitute for achieving postero-lateral fusion in the treatment of degenerative spine diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Agathe Fevrier, Charles Boursot, Kevin Cohen Tannugi
Summary: Effective local antibiotic therapy for chronic osteomyelitis can be achieved by implanting gentamicin-PMMA chains after surgical debridement. This treatment shows particular radiological aspects and is important for identifying osteomyelitis.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Rui Zhang, Nisarat Ruangsawasdi, Piyapanna Pumpaluk, Quan Yuan, Yi Peng, Dutmanee Seriwatanachai
Summary: This study investigated the biological effects and bone regeneration properties of tooth-derived bone substitute (TDBS) in vitro and in vivo using a rat periodontal bone defect model. The results showed that TDBS demonstrated osteoinductive properties and can be suggested as an economical and biocompatible material for periodontal bone regeneration.
Article
Chemistry, Analytical
Hye-In Kim, Naren Raja, Youngjun Choi, Jueun Kim, Aram Sung, Yeong-Jin Choi, Hui-suk Yun, Honghyun Park
Summary: Developments in 3D printing technologies have led to potential applications in biomedical fields, particularly in artificial bone substitutes (ABS). Multifunctional ABSs have been designed to address biocompatibility and infection issues by including a biochemical modality for detecting infection biomarkers. The ABSs consist of calcium-deficient hydroxyapatite (CDHA) and gold nanoparticles (Au NPs) to promote osteogenesis and enable fluorescence detection of specific target biomarkers.
Article
Education, Scientific Disciplines
Holly N. Hellawell, Harry Kyriacou, Anoop S. Sumal
Summary: Emergency department placements offer medical students numerous clinical and practical learning opportunities, but the busy environment may not always be conducive to optimal learning. Prior knowledge on how to make the most of emergency medicine placements can facilitate student learning and enjoyment.
Article
Orthopedics
Achi Kamaraj, Nikhil Agarwal, K. T. Matthew Seah, Wasim Khan
Summary: With the increasing importance of cost-utility analysis studies in reducing healthcare spending, particularly in trauma and orthopaedics, it is crucial for surgeons in this field to understand economic evaluations to make informed cost-effective decisions. Different methods are employed to assess health outcomes and calculate costs, and various model designs can be used for conducting a CUA, with a focus on real-life clinical studies and computer-simulated modeling. Sensitivity analysis is used to quantify uncertainty, and instruments are employed to assess the quality of CUAs, while recognizing important limitations that need to be considered.
EFORT OPEN REVIEWS
(2021)
Letter
Education, Scientific Disciplines
Harry Kyriacou, Holly N. Hellawell, Anoop S. Sumal
Review
Cell Biology
Nikhil Agarwal, Christopher Mak, Christine Bojanic, Kendrick To, Wasim Khan
Summary: Cell-based therapies derived from adipose tissue, specifically AMSC therapy and SVF therapy, have been shown to be safe and effective treatments for knee OA in old adults, reducing pain and improving knee function over time.
Review
Cell Biology
Conor A. Crowley, William P. W. Smith, K. T. Matthew Seah, Soo-Keat Lim, Wasim S. Khan
Summary: Adipose tissue senescence is linked to obesity and aging-related diseases, and adipose-derived stem cells are used in regenerative medicine. Cryopreservation allows for greater flexibility in tissue use. Trehalose, a sugar synthesized by lower organisms, has been tested as a cryoprotective agent, showing comparable effectiveness to DMSO when introduced into cells using appropriate methods.
Review
Biochemistry & Molecular Biology
Ilias Ektor Epanomeritakis, Ernest Lee, Victor Lu, Wasim Khan
Summary: Focal chondral defects of the knee are common in young, active individuals, and cell-seeded scaffolds have shown promising results in repairing these defects. Most patients achieved complete integration with native cartilage using cell-seeded scaffolds, and the integration quality improved over time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Jude Abu El Afieh, Marena Gray, Matthew Seah, Wasim Khan
Summary: Ewing's sarcoma (ES) is a rare bone cancer that is treated with radiotherapy, chemotherapy, and surgical resection. Existing literature combines data on endoprosthetic reconstruction in ES patients with osteosarcoma. This review aimed to evaluate the outcomes of limb salvage surgery with endoprostheses solely in ES patients. Data was collected from 17 studies involving 57 ES patients, and the majority of patients preserved their limbs after the procedure. The most common postoperative complications were soft tissue failure and deep infection. Despite limitations, there is a suggestion of good functional outcomes with limb salvage surgery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Astronomy & Astrophysics
Patrick Swain, Marie Mortreux, Jonathan M. Laws, Harry Kyriacou, Enrico De Martino, Andrew Winnard, Nick Caplan
Summary: Space agencies are planning to send humans back to the Lunar surface, in preparation for crewed exploration of Mars. However, the effect of hypogravity on human skeletal muscle is largely unknown. A recently established rodent partial weight-bearing model has been employed to mimic various levels of hypogravity loading and may provide valuable insights to better understanding how human muscle might respond to this environment.
LIFE SCIENCES IN SPACE RESEARCH
(2022)
Review
Astronomy & Astrophysics
Patrick Swain, Marie Mortreux, Jonathan M. Laws, Harry Kyriacou, Enrico De Martino, Andrew Winnard, Nick Caplan
Summary: This study investigates the effects of partial weight-bearing (PWB) on the skeletal system of rodents and suggests that extended periods of PWB can lead to loss of bone density, volume, and strength. These findings have implications for human exploration of the Moon and Mars and highlight the need for countermeasures against bone deconditioning.
LIFE SCIENCES IN SPACE RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Justin Ho, Christopher Chi Hang Mak, Vivek Sharma, Kendrick To, Wasim Khan
Summary: This systematic review examined Mendelian randomization (MR) studies on risk factors and causal effects of osteoarthritis (OA) and conducted a meta-analysis. The findings indicate that body mass index (BMI) has a positive causal effect on OA, while serum calcium and low-density lipoprotein (LDL) levels have negative causal effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Goran Rondovic, Dragan Djordjevic, Ivo Udovicic, Ivan Stanojevic, Snjezana Zeba, Tanja Abazovic, Danilo Vojvodic, Dzihan Abazovic, Wasim Khan, Maja Surbatovic
Summary: This article evaluates the existing strategies of immunomodulatory treatment in COVID-19 and discusses the controversy surrounding the addition of a second immunomodulatory drug. Due to the uncertainty of the immunopathogenesis, selecting the appropriate immunomodulatory drug remains challenging.
Review
Biochemistry & Molecular Biology
Charindu K. I. Ranmuthu, Chanuka D. S. Ranmuthu, Chalukya K. Wijewardena, Matthew K. T. Seah, Wasim S. Khan
Summary: This systematic review explores the effect of hypoxia on chondrogenic differentiation of human adult mesenchymal stromal cells (MSCs). Most studies suggest that hypoxia during the expansion or differentiation phase enhances some markers of chondrogenic differentiation in adult MSCs. However, results are inconsistent and not always confirmed at the protein level. Factors such as MSC source, donor variability, hypoxia level, exposure time, and culture methodology contribute to these inconsistent findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Antonia Vogt, Konstantinos Kapetanos, Neophytos Christodoulou, Dimitrios Asimakopoulos, Mark A. Birch, Andrew W. McCaskie, Wasim Khan
Summary: Tissue engineering and cell therapy have the potential to treat chronic disorders. This systematic review aims to assess the influence of patient age on the chondrogenic potential of mesenchymal stromal cells (MSCs) in regenerative therapy. The review reveals conflicting outcomes regarding the chondrogenic potential of MSCs in relation to age.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Parviz Vahedi, Rana Moghaddamshahabi, Thomas J. Webster, Ayse Ceren Calikoglu Koyuncu, Elham Ahmadian, Wasim S. Khan, Ali Jimale Mohamed, Aziz Eftekhari
Summary: Cartilage damage is often difficult to repair, and current treatment strategies are inadequate. Autologous mesenchymal stem cells are considered a promising therapeutic approach for cartilage regeneration, as they possess robust cartilaginous production capacity and are easy to isolate and expand without causing morbidity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Orthopedics
Haowen Kwan, Kendrick To, Christine Bojanic, Karl Romain, Wasim Khan
Summary: Simultaneous bilateral Unicompartmental Knee Arthroplasty (UKA) shows comparable clinical and radiological outcomes to staged bilateral UKA, while offering advantages in terms of shorter operation and hospital stay, as well as lower treatment cost. Concerns about increased risk of complications, revisions, and mortality with simultaneous surgery do not appear to be supported by the evidence reviewed.
JOURNAL OF ORTHOPAEDICS
(2021)
