Article
Cell Biology
Xiaoxia Dong, Yongyu Liu, Xinzhou Deng, Jun Shao, Shuangyue Tian, Shuang Chen, Rongxin Huang, Ziao Lin, Chunli Chen, Li Shen
Summary: C1GALT1, highly expressed in lung adenocarcinoma tissues, promotes tumor progression by upregulating RAC1 and is negatively regulated by miR-181d-5p. Targeting C1GALT1 may hold promise as a therapeutic strategy for lung adenocarcinoma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Pengling Wang, Tianli Zhang, Nan Jiang, Kun Wang, Liping Feng, Ting Liu, Xingsheng Yang
Summary: This study identifies PDIA6 as a significant player in endometrial cancer, promoting malignant behavior of cancer cells through regulation of the TGF-beta pathway and modulation by the TRPM2-AS/miR-424-5p axis. Therefore, PDIA6 may be a potential target for endometrial cancer therapy.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Chang-Jun Tong, Qing-Chun Deng, Di-Jun Ou, Xia Long, He Liu, Kang Huang
Summary: The upregulation of lncRNA RUSC1-AS1 in osteosarcoma promotes cell proliferation, invasion, and inhibits apoptosis, as well as enhances the epithelial-mesenchymal transition (EMT) process. Inhibition of RUSC1-AS1 also showed suppressive effects on tumor growth in vivo, indicating its potential as a therapeutic target for osteosarcoma.
Article
Cell Biology
Yongmeng Li, Yanfei Liu, Kai Jin, Rui Dong, Cun Gao, Libo Si, Zitong Feng, Huiying Zhang, Hui Tian
Summary: MTFR1 is upregulated in LUAD and associated with poor clinicopathologic features and prognosis. Overexpression of MTFR1 promotes proliferation, invasion, migration, glycolytic capacity, and inhibits apoptosis of LUAD cells. MTFR1 may exert its functions through the AMPK/mTOR signaling pathway and is targeted by miR-29c-3p. Targeting MTFR1 could be an effective therapeutic strategy for LUAD treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Liyao Dong, Lin Zhang, Xinyun Zhao, Hongling Zou, Sisi Lin, Xinping Zhu, Jili Cao, Chun Zhou, Zhihong Yu, Yongqiang Zhu, Kequn Chai, Mingqian Li, Qun Li
Summary: This study elucidates the molecular mechanism whereby CYP4A22-AS1 overexpression promotes LUAD progression through the miR-205-5p/EREG and miR-34c-5p/BCL-2 axes.
CANCER CELL INTERNATIONAL
(2023)
Article
Biotechnology & Applied Microbiology
Xiaolong Qiao, Yinan Chen, Zixuan Wang, Nan Peng, Wanxiang Niu, Shiqiang Hou, Jiaying Wu, Ying Ji, Chaoshi Niu, Chuandong Cheng
Summary: The study shows that GTF2E2 is overexpressed in glioma and is associated with poor prognosis. The biological functions of GTF2E2 were investigated in vitro and in vivo, and it was found to be regulated by miR-340-5p, affecting downstream gene expressions and glioma progression.
CANCER GENE THERAPY
(2023)
Article
Cell Biology
Yangwei Xu, Yanyan Li, Yue Qiu, Fei Sun, Guifang Zhu, Jingbo Sun, Guixing Cai, Wanmei Lin, Yun Fu, Hongmei Wu, Shanshan Jiang, Zhihui Wen, Feiyan Feng, Junjie Luo, Yuqin Yang, Qingling Zhang
Summary: NEAT1 is upregulated in most GC samples and is associated with poor prognosis. It promotes GC angiogenesis by competitively sponging miR-17-5p to activate the TGF beta/Smad pathway and upregulate proangiogenic factors like VEGF.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Pengling Wang, Ting Liu, Zhendan Zhao, Zhiling Wang, Shujie Liu, Xingsheng Yang
Summary: The study demonstrated that SPTBN2 is overexpressed in EEC and associated with poor prognosis, with its knockdown inhibiting cell proliferation, migration, and invasion. SPTBN2 interacts with CLDN4 to promote endometrial cancer metastasis via the PI3K/AKT pathway.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Mingyan Xu, Junling Zhang, Xuemei Lu, Fan Liu, Songlin Shi, Xiaoling Deng
Summary: SMARCA4 is highly upregulated in oral squamous cell carcinoma (OSCC) tissues, promoting cell invasion and tumor growth. Mechanistic studies reveal that miR-199a-5p-regulated SMARCA4 promotes tumor cell invasion and metastasis through epithelial-mesenchymal transition (EMT). These findings provide insights into the role of SMARCA4 in OSCC and have important implications for therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Kai Guo, Di Qi, Bo Huang
Summary: The study revealed that lncRNA MEG8 plays a critical role in the development of NSCLC by modulating the miR-15a/b-5p/PSAT1 axis, indicating that lncRNA MEG8, miR-15a-5p, miR-15b-5p, and PSAT1 may serve as potential targets for NSCLC therapy.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Jianping Zhang, Shengming Jin, Wenjun Xiao, Xuchao Zhu, Chengyou Jia, Zongming Lin
Summary: The study revealed that overexpressed LINC00641 in RCC tissues and cell lines promotes RCC progression by sponging miR-340-5p, leading to enhanced proliferation, invasion, and colony formation capacities in vitro. This effect was confirmed in vivo experiments.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Nanbin Yu, Huaijun Gong, Wei Chen, Weixing Peng
Summary: Circ-ZKSCAN1 promotes the tumorigenesis and cisplatin resistance in lung adenocarcinoma by regulating the miR-185-5p/TAGLN2 axis.
Article
Biochemistry & Molecular Biology
Wugang Zhou, Lv Ji, Xuqin Liu, Dan Tu, Ningning Shi, Wangmu Yangqu, Shi Chen, Pingjin Gao, Hong Zhu, Chengchao Ruan
Summary: This study reveals that AIFM1 is upregulated in myocardial infarction while miR-145-5p is downregulated. Upregulation of AIFM1 may exacerbate myocardial ischemic injury by promoting inflammation and cardiomyocyte injury, and the downregulation of miR-145-5p may be one of the reasons for the upregulation of AIFM1.
BIOMEDICAL JOURNAL
(2022)
Article
Oncology
Zhendan Zhao, Zhiling Wang, Pengling Wang, Shujie Liu, Yingwei Li, Xingsheng Yang
Summary: The study identified EPDR1 as a tumor-suppressor gene negatively regulated by miR-429 in EOC development, inhibiting proliferation, migration, and invasion of cancer cells through the PI3K/AKT pathway. The miR-429/EPDR1 axis may offer novel therapeutic targets for personalized treatment of EOC patients in the future.
FRONTIERS IN ONCOLOGY
(2021)
Article
Orthopedics
Lun Fang, Zhongzhe Li, Beilei Yu, Lu Zhou
Summary: This study reveals that FGF23 is highly expressed in osteosarcoma cells and overexpression of FGF23 significantly promotes the proliferation, migration, and invasion of osteosarcoma cells. Further investigation suggests that FGF23 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-340-5p gene expression.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Construction & Building Technology
Bing Cui, Huanling Wu, Canhui Zhao, Jiaping Liu, Zhiming Guo
Summary: Nanjing Jiangxinzhou Yangtze River Bridge is an innovative cable-stayed bridge in China with a unique steel-concrete composite structure. With the use of new materials, such as coarse aggregate reactive powder concrete, it has significantly improved the manufacturing speed and performance of the bridge, making significant contributions to the development of cable-stayed bridges.
STRUCTURAL ENGINEERING INTERNATIONAL
(2023)
Article
Construction & Building Technology
Yang Zhou, Yuan Chen, Ming Jin, Jiaping Liu, Changwen Miao
Summary: In this study, molecular dynamics simulations were used to investigate the effects of irradiation on cementitious materials. The results showed that irradiation led to a transformation in structure and a reduction in mechanical performance of calcium silicate hydrates. Additionally, an increase in ductility was observed, which could be beneficial for designing more radiation-resistant cement materials.
JOURNAL OF SUSTAINABLE CEMENT-BASED MATERIALS
(2023)
Article
Clinical Neurology
Shuiwei Xia, Yajie Wang, Xianli Lv, Chunmiao Chen, Junguo Hui, Xulu Wu, Zufei Wang, Huijun Chen, Jiansong Ji
Summary: This study compared the abilities of vessel wall magnetic resonance imaging techniques, SNAP sequence and T1-weighted volumetric isotropic turbo spin echo acquisition (T1-w VISTA) sequence, in evaluating cervical artery dissection (CAD). The results showed that both SNAP and T1-w VISTA sequences had the same diagnostic performance in CAD diagnosis, and their consistencies with the final diagnosis were good. Additionally, SNAP showed better intramural hematoma (IMH)-wall contrast than T1-w VISTA.
INTERVENTIONAL NEURORADIOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Gang Liu, Zhitao Han, Jiawei Li, Zhen Wang, Shaosi Cheng, Yubin Liu, Jing Yu, Xinxiang Pan
Summary: A novel method for removing pre-oxidized NOx using Na2SO3/THS composite solution is proposed in this study, aiming to achieve high NOx absorption efficiency and low nitrate concentration in scrubbed wastewater simultaneously.
ENVIRONMENTAL PROGRESS & SUSTAINABLE ENERGY
(2023)
Article
Environmental Sciences
Nianping Chi, Jiajun Liu, Minghua Lei, Li Feng
Summary: The introduction of amphiphilic CPAM TP-ADB with cationic microblock structure and hydrophobic association improves the dewatering performance of PD sludge.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Jiawei Li, Guoqiang Song, Zhenzhen Mu, Xiaoou Lan, Fan Yang, Lin Li, Xiuping Han
Summary: Several studies have shown a relationship between short-term exposure to air pollution and worsening of certain skin conditions. This study in Shenyang, China, from 2016 to 2018, expands on these findings by exploring the potential association between exposure to air pollutants including particulate matter, sulfur dioxide, and ozone and the incidence of acute and chronic urticaria. The results suggest that short-term exposure to ozone, PM2.5, and PM10 can increase the risk of acute and chronic urticaria.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Oncology
Honghui Zhao, Dan Li, Jiayin Liu, Xinliang Zhou, Jing Han, Long Wang, Zhisong Fan, Li Feng, Jing Zuo, Yudong Wang
Summary: This study analyzed the characteristics of gut microbes in lung cancer patients and found that the differences in gut microbes are related to the effectiveness of anti-PD-1 therapy combined with chemotherapy. In particular, Bifidobacterium breve was identified as a potential biomarker for predicting efficacy.
Article
Chemistry, Applied
Niuniu Cui, Jiawei Li, Ziwen Xie, Xiaofei Yan, Dongming Qi
Summary: The study introduces a novel pigment dyeing technology that uses charge attractions between cationic nanoscale pigment and cotton fabrics. This technology offers advantages such as no salt, recyclable dyebath, high uptake, and good wet fastness. The research explores the synthesis of cationic copolymer nanoparticle dispersants and the preparation of nanoscale pigment dispersion. The results demonstrate the excellent dispersion performance and colloid stability of the nanoscale pigment dispersion, as well as the higher coloring intensity and color fastness achieved in the dyeing of cotton fabrics. The recyclability of the dyebath significantly reduces dyeing effluent discharge, providing a promising and ecologically sustainable dyeing technology for cotton fabrics.
Article
Environmental Sciences
Hongyi Wu, Ling Xie, Yuchen Wu, Liwei Chen, Bian Jiang, Xiaohai Chen, Yinglin Wu
Summary: This study investigated the accumulation of total petroleum hydrocarbons (TPHs) on the coast of Leizhou Peninsula in Southern China. Land-based discharge, sea traffic, and sediment type were found to significantly influence TPHs distribution. The concentration of TPHs increased by 1.036 μg/g with the addition of one more boat on the wharf. 'Blue Carbon' ecosystems, such as mangroves, were more severely polluted. Cleaner production policies should be implemented to mitigate TPHs discharge from coastal areas.
MARINE POLLUTION BULLETIN
(2023)
Article
Engineering, Multidisciplinary
Jun Li, Jia Wei Li, Jia Rui Zhang, Kuo Li, Tian Ma, Wei Feng Wang, Xiao Wei Zhai, William N. MacPherson, Robert R. J. Maier, Duncan P. Hand
Summary: In this paper, we demonstrate the design and fabrication of 45 degrees micro-mirrors using focused ion beam (FIB) processing. The mirrors are accurately aligned with optical fibre cores, eliminating the need for alignment of external turning mirror components. Experimental results show that the fabricated structure is capable of measuring two-axis acceleration with a linear response range of 0.2 to 4 g and an rms. error of 0.03 g. Frequency response up to 700 Hz and cross-sensitivity of approximately 4.3% are also demonstrated.
MEASUREMENT SCIENCE AND TECHNOLOGY
(2023)
Article
Spectroscopy
Qi Xiao, Huajian Luo, Huishan Cao, Bo Li, Jiajia Liu, Yi Liu, Shan Huang
Summary: Ti3C2 quantum dots were synthesized and successfully applied for fluorescent imaging of living cells. The binding interaction between Ti3C2 QDs and trypsin was comprehensively studied using spectroscopic strategies and molecular modeling technique. The results show that Ti3C2 QDs can quench the intrinsic fluorescence of trypsin and significantly inhibit its enzymatic activity on human serum albumin and cells.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Spectroscopy
Ling Lin, Meiling Fan, Muhammad Ijaz, Leiyang Cheng, Gang Li
Summary: In the LED multi-spectral imaging (LEDMSI) system, modulation using square wave frequency division with a frequency ratio of 2 can improve image quality and acquisition speed, but it occupies a wide frequency band. This paper proposes a modulation method using multiple square wave signals with different phases as carrier signals to solve the above problems. Experimental results show that the proposed method improves the quality of multi-spectral images, indicating its significance in improving the performance of the LEDMSI system.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Computer Science, Artificial Intelligence
Yiyang Liu, Hua Dai, Jiawei Li, Yu Chen, Geng Yang, Jun Wang
Summary: This paper proposes a BP-Model-based convoy mining algorithm that optimizes mining by adopting the divide-and-conquer methodology. The performance of the algorithms is evaluated on real-world datasets, showing that they are more efficient than existing convoy mining algorithms.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Jia-Wei Li, Jian-Gang Guo, Li-Jun Zhou
Summary: Many studies have shown that the nanotwinned structure and graphene reinforcing phase can improve the mechanical properties of aluminum. However, the synergistic effect of the two on the strengthening and toughening mechanisms of aluminum matrix composites has rarely been reported. In this work, molecular dynamics simulations are used to study the mechanical properties and microscopic deformation mechanisms of graphene/nanotwinned aluminum matrix composites. The effects of graphene distribution patterns, twin boundaries (TBs), their angles, and the number of graphene layers on the mechanical behaviors of the composites are analyzed.
PHYSICA E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES
(2023)
Article
Computer Science, Artificial Intelligence
Xiang Shi, Yinpeng Liu, Jiawei Liu, Qikai Cheng, Wei Lu
Summary: Scientific papers are crucial for academic communication, but many of them lack in-depth research and present core content ambiguously, hindering the progression of science and technology. To address this challenge, the INTEGrity vERification (INTEGER) task is introduced to help researchers assess the integrity of their papers and verify the clarity of each knowledge unit. A multi-task learning model utilizing Tucker decomposition and span-level attention mechanism is proposed to accurately identify terms and their integrity. Experimental results show the effectiveness of the model.
EXPERT SYSTEMS WITH APPLICATIONS
(2024)