Article
Immunology
Zijun Yang, Dongxu Song, Yulin Wang, Lin Tang
Summary: This study investigates the role of MALAT1 in diabetic nephropathy (DN) and reveals that MALAT1 knockdown alleviates high glucose-induced damage in HK-2 cells through the inhibition of the miR-15b-5p/TLR4 axis. MALAT1 may serve as a potential biomarker and therapeutic target for DN.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Cell Biology
Shihua Sui, Lei Sun, Wenjing Zhang, Jiamei Li, Jingcui Han, Jiaping Zheng, Hua Xin
Summary: This study revealed that MEG8 regulates angiogenesis and attenuates cerebral ischemia after ischemic stroke through the miR-130a-5p/VEGFA signaling pathway.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Boxin Yao, Lichao Ye, Jixing Chen, Shitu Zhuo, Huasong Lin
Summary: Our study revealed the protective role of LINC00473 in cerebral I/R injury, suggesting it may serve as a novel target for treating ischemic brain injury.
Article
Clinical Neurology
Rukiye Tekdemir, Yavuz Selvi, Kursat Altinbas, Nadir Kocak
Summary: This study found that miRNAs play an important role in the pathogenesis of bipolar disorder and may serve as biomarkers for diagnosis and screening of the disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Oncology
Jishui Zhang, Wenhao Lv, Yagang Liu, Weihua Fu, Baosheng Chen, Qiutong Ma, Xin Gao
Summary: This study demonstrated that LINC_00355 promotes GC progression by up-regulating PHF19 through sponging miR-15a-5p. Knockdown of LINC_00355 inhibited cell viability, migration, invasion, and induced apoptosis in GC cells, while overexpression had the opposite effects. PHF19 overexpression reversed the effect of LINC_00355 knockdown on GC cell properties. These findings provide important insights for potential clinical intervention in reversing the malignant phenotype of GC.
Article
Neurosciences
Zhen Liu, Bei Tao, Linkun Li, Pin Liu, Kaiguo Xia, Chuanhong Zhong
Summary: This study revealed that LINC00511 is up-regulated in glioma and its knockdown inhibits glioma cell progression through the miR-15a-5p/AEBP1 axis.
BRAIN RESEARCH BULLETIN
(2021)
Article
Oncology
Xiaojing Liu, Na Niu, Pibao Li, Liping Zhai, Ke Xiao, Wendan Chen, Xuewei Zhuang
Summary: The study found that the expression of OGFRP1 was higher in NSCLC tissues than in normal lung tissue; siOGFRP1 inhibited the proliferation, migration, and invasion of A549 and H1299 cells to inhibit the progression of NSCLC, and OGFRP1 could directly interact with miR-4640-5p to regulate the development of NSCLC through the miR-4640-5p/eIF5A axis.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Mingyu Jiang, Jicheng Dai, Mingying Yin, Chunming Jiang, Mingyong Ren, Lin Tian
Summary: LncRNA MEG8 downregulation and M2 polarization in Henoch Schonlein purpura rats. MEG8 upregulation enhances M1 polarization and suppresses JAK2/STAT3 pathway. MEG8 sponges miRNA-181a-5p to regulate SHP2 expression. MiRNA-181a-5p upregulation reverses lncRNA MEG8-mediated enhancement of M1 polarization and inhibition of JAK2/STAT3 pathway. SHP2 downregulation reverses lncRNA MEG8-mediated enhancement of M1 polarization and inhibition of JAK2/STAT3 pathway.
ANNALS OF MEDICINE
(2021)
Article
Oncology
Xuanyu Chen, Song Chen
Summary: The study aimed to explore the effects of LINC00649 on the proliferation, migration, and invasion of bladder cancer and identified a potential mechanism involving the regulation of the miR-15a-5p/HMGA1 axis. High expression of LINC00649 was associated with poor overall survival in bladder cancer patients, while upregulation of LINC00649 enhanced the malignant progression of bladder cancer cells in vitro. This suggests that LINC00649 may serve as a biomarker and therapeutic target for bladder cancer.
Article
Pathology
Peng Ge, Lei Cao, Ming Zheng, Yuejuan Yao, Wei Wang, Xin Chen
Summary: SNHG1 promotes cisplatin resistance and malignant behaviors of NSCLC cells by targeting miR-330-5p and elevating the level of DCLK1.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Medicine, Research & Experimental
Yuqin Ding, Yuting Huang, Fanrong Zhang, Lijie Gong, Chenlu Liang, Kaijing Ding, Xiangming He, Xiaowen Ding, Yiding Chen
Summary: Our study investigated the role of lncRNA TDRKH-AS1 in breast cancer (BC). We found that TDRKH-AS1 was upregulated in BC tissues and cell lines, and its high expression was associated with advanced stages and poor outcomes in BC patients. Knockdown of TDRKH-AS1 inhibited BC cell proliferation and invasion. Mechanistically, TDRKH-AS1 acted as a sponge for miR-134-5p, thereby promoting the expression of cAMP response element-binding protein 1 (CREB1), a downstream target of miR-134-5p. In vivo experiments confirmed the tumor-promoting role of TDRKH-AS1 in BC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Weiwei Chen, Kundong Zhang, Yuhan Yang, Zengya Guo, Xiaofeng Wang, Buwei Teng, Qian Zhao, Chen Huang, Zhengjun Qiu
Summary: This study found significantly downregulated HCP5 expression in gastric cancer tissues, and depletion of HCP5 facilitated cell proliferation, migration, and invasion. Moreover, MEF2A-mediated HCP5 exerted an anti-tumor effect in gastric cancer development through the miR-106b-5p/p21 axis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Shuyi Han, Yan Qi, Yihui Xu, Min Wang, Jun Wang, Jing Wang, Mingjie Yuan, Yanfei Jia, Xiaoli Ma, Yunshan Wang, Xiangdong Liu
Summary: DLEU2 is significantly up-regulated in GC tissues and cell lines, associated with pathological grading and TNM stage of GC patients. MiR-30a-5p can directly bind to the 3' UTR region of ETS2. DLEU2 binds to miR-30a-5p to facilitate ETS2 expression.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Fang Wang, Meixia Zhang
Summary: The study found that circ_001209 promotes diabetic retinal vascular dysfunction by regulating the expression of miR-15b-5p and COL12A1. This provides a potential treatment strategy for diabetic retinopathy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Bo Liu, Duocheng Qian, Weidong Zhou, Huiyang Jiang, Zhendong Xiang, Denglong Wu
Summary: The study reveals that FAM83H-AS1 is upregulated in prostate cancer and plays a critical role in tumorigenesis by modulating cell proliferation, cell cycle, and migration. Mechanistically, FAM83H-AS1 functions as an oncogene through sponging miR-15a to promote CCNE2 expression, indicating its potential as a novel diagnostic and therapeutic marker for prostate cancer.
FRONTIERS IN ONCOLOGY
(2021)