Journal
NANOMATERIALS
Volume 10, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/nano10061087
Keywords
copper-cysteamine nanoparticle; mice; radiation energies; size; reactive oxygen species; tumor; X-ray; photodynamic therapy
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Funding
- Suzhou Jailuoyuan
- Solgro Inc.
- University of Texas at Arlington
- University of Science and Technology
- Liaoning Talent Project Grants [601010302]
- Institutional Development Award (IDeA) Network for Biomedical Research Excellence from the National Institute of General Medical Sciences of the National Institutes of Health [P20GM103430]
- University of Rhode Island
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The Copper-cysteamine (Cu-Cy) nanoparticle is a novel sensitizer with a potential to increase the effectiveness of radiation therapy for cancer treatment. In this work, the effect of nanoparticle size and the energy of X-rays on the effectiveness of radiation therapy are investigated. The effect of the particle size on their performance is very complicated. The nanoparticles with an average size of 300 nm have the most intense photoluminescence, the nanoparticles with the average size of 100 nm have the most reactive oxygen species production upon X-ray irradiation, while the nanoparticles with the average size of 40 nm have the best outcome in the tumor suppression in mice upon X-ray irradiation. For energy, 90 kVp radiation resulted in smaller tumor sizes than 250 kVp or 350 kVp radiation energies. Overall, knowledge of the effect of nanoparticle size and radiation energy on radiation therapy outcomes could be useful for future applications of Cu-Cy nanoparticles.
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