Small Molecules Targeting H3K9 Methylation Prevent Silencing of Reactivated FMR1 Alleles in Fragile X Syndrome Patient Derived Cells

A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis

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Association between IQ and FMR1 protein (FMRP) across the spectrum of CGG repeat expansions

(2020) Kyoungmi Kim et al.   PLoS One

FMR1 Reactivating Treatments in Fragile X iPSC-Derived Neural Progenitors In Vitro and In Vivo

(2019) Dan Vershkov et al.   Cell Reports

High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation

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Epigenetic mechanism of FMR1 inactivation in Fragile X syndrome

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UNC0638, a G9a inhibitor, suppresses epithelial‑mesenchymal transition‑mediated cellular migration and invasion in triple negative breast cancer

(2017) Xiang‑Rong Liu et al.   Molecular Medicine Reports

Fragile X syndrome

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Sustained expression ofFMR1mRNA from reactivated fragile X syndrome alleles after treatment with small molecules that prevent trimethylation of H3K27

(2016) Daman Kumari et al.   HUMAN MOLECULAR GENETICS

A Set of Assays for the Comprehensive Analysis of FMR1 Alleles in the Fragile X–Related Disorders

(2016) Bruce E. Hayward et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Genome-wide methylation analysis demonstrates that 5-aza-2-deoxycytidine treatment does not cause random DNA demethylation in fragile X syndrome cells

(2016) Elisabetta Tabolacci et al.   Epigenetics & Chromatin

CGG-repeat dynamics and FMR1 gene silencing in fragile X syndrome stem cells and stem cell-derived neurons

(2016) Yifan Zhou et al.   Molecular Autism

Effect of BIX-01294 on H3K9me2 levels and the imprinted gene Snrpn in mouse embryonic fibroblast cells

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EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression

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Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90

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A cost-effective and efficient reprogramming platform for large-scale production of integration-free human induced pluripotent stem cells in chemically defined culture

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High-Throughput Screening to Identify Compounds That Increase Fragile X Mental Retardation Protein Expression in Neural Stem Cells Differentiated From Fragile X Syndrome Patient-Derived Induced Pluripotent Stem Cells

(2015) Daman Kumari et al.   Stem Cells Translational Medicine

Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription

(2014) D. Kumari et al.   HUMAN MOLECULAR GENETICS

Identification of Fragile X Syndrome Specific Molecular Markers in Human Fibroblasts: A Useful Model to Test the Efficacy of Therapeutic Drugs

(2014) Daman Kumari et al.   HUMAN MUTATION

Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma

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Fragile X Syndrome: A Review of Associated Medical Problems

(2014) S. A. Kidd et al.   PEDIATRICS

Promoter-Bound Trinucleotide Repeat mRNA Drives Epigenetic Silencing in Fragile X Syndrome

(2014) D. Colak et al.   SCIENCE

DZNep, inhibitor of S-adenosylhomocysteine hydrolase, down-regulates expression of SETDB1 H3K9me3 HMTase in human lung cancer cells

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CGG Repeat-Associated Translation Mediates Neurodegeneration in Fragile X Tremor Ataxia Syndrome

(2013) Peter K. Todd et al.   NEURON

Sequestration of DROSHA and DGCR8 by Expanded CGG RNA Repeats Alters MicroRNA Processing in Fragile X-Associated Tremor/Ataxia Syndrome

(2013) Chantal Sellier et al.   Cell Reports

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

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Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients

(2010) Chantal Sellier et al.   EMBO JOURNAL

The distribution of repressive histone modifications on silenced FMR1 alleles provides clues to the mechanism of gene silencing in fragile X syndrome

(2010) D. Kumari et al.   HUMAN MOLECULAR GENETICS

Involvement of Histone H3 Lysine 9 (H3K9) Methyltransferase G9a in the Maintenance of HIV-1 Latency and Its Reactivation by BIX01294

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DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

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Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

(2009) Yanqi Chang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition

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Epigenetic mechanisms in mammals

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Epigenetic analysis reveals a euchromatic configuration in the FMR1 unmethylated full mutations

(2008) Elisabetta Tabolacci et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

HDAC Inhibitors Correct Frataxin Deficiency in a Friedreich Ataxia Mouse Model

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SIRT1 Inhibition Alleviates Gene Silencing in Fragile X Mental Retardation Syndrome

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