Article
Plant Sciences
Xiaoli Wang, Qiaoyu He, Qian Chen, Beibei Xue, Jia Wang, Tao Wang, Hong Liu, Xiaopeng Chen
Summary: This study combined network pharmacology and metabolomics to explore the potential mechanism of Shenyan Kangfu Tablets (SYKFT) in treating diabetic nephropathy (DN), identifying potential active components, related targets, and biomarkers. The results suggest that the potential mechanism of SYKFT in treating DN is most related to insulin resistance (IR), demonstrating the feasibility of using network pharmacology and metabolomics to study the mechanisms of herbal treatments for complex diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Tang Dan, He Wen-Jiao, Zhang Zhi-Tong, Shi Jing-Jing, Wang Xue, Gu Wen-Ting, Chen Zhi-Quan, Xu You-Hua, Chen Yun-Bo, Wang Shu-Mei
Summary: This study revealed the potential mechanism and nephroprotective effects of Huang-Lian-Jie-Du Decoction (HLJDD) against diabetic nephropathy through a comprehensive approach of network pharmacology, pharmacodynamics, molecular biology, and metabolomics. The findings suggest that HLJDD ameliorates diabetic nephropathy by regulating the AGEs/RAGE/Akt/Nrf2 pathway and metabolic profiling.
Article
Integrative & Complementary Medicine
Gao Qiang, Han Zhen-Yun, Tian Dan-Feng, Liu Gan-Lu, Wang Zhen-Yi, Lin Jing-Feng, Chang Ze, Zhang Dan-Dan, Xie Ying-Zhen, Sun Yi-Kun, Yao Xing-Wei, Ma Da-Yong
Summary: This study investigated the brain protection mechanism of Xinglou Chengqi Decoction (XCD) in stroke through gut microbiota analysis and network pharmacology. XCD improved neurological function by regulating gut microbiota and releasing anti-inflammatory factors, as well as promoting the release of SCFAs. The characteristics of XCD in stroke treatment include multi-component, multi-target, and multi-channel effects, as revealed by network pharmacology and molecular docking.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Pharmacology & Pharmacy
Xiaomin Xu, Cheng Fang, Yu Wang, Fang Lu, Shumin Liu
Summary: In this study, the mechanisms of Huang Qin Decoction (HQD) for the treatment of diabetic liver injury (DLI) were evaluated using metabonomics and system pharmacology. The results showed that HQD could significantly alter the levels of 18 metabolites and recover the biomarkers in the model group. Additionally, 8 signaling pathways related to HQD were explored. The integrated approach of metabolomics and network pharmacology identified 10 key genes, partially consistent with the results of metabolomics. These findings suggest that HQD has potential therapeutic effects on DLI and provide insights into its underlying mechanisms.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Tao Ji, Juan Wang, Zhuo Xu, Hong-Die Cai, Shu-Lan Su, Xin Peng, Hong-Sheng Ruan
Summary: This study investigated the protective and synergistic effect of a combination of mulberry leaf alkaloids and flavonoids extract on diabetic nephropathy (DN). The results showed that these compounds had anti-DN activity and could regulate various metabolic pathways. MAF(1:1) and MAF(1:5) had superior therapeutic effects compared to the single use of MA or MF, indicating a synergistic effect. These findings are scientifically significant and valuable for understanding the benefits of mulberry leaf in preventing and treating DN.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Lili Sun, Zhigang Yang, Wei Zhao, Qin Chen, Haiying Bai, Shanshan Wang, Li Yang, Chunmei Bi, Yanbin Shi, Yingqian Liu
Summary: Danggui Buxue Decoction (DBT) has therapeutic effects on diabetic nephropathy by affecting lipid metabolism, reducing lipid accumulation, and promoting Akt phosphorylation. Network pharmacology analysis revealed that components in DBT could regulate multiple signaling pathways in diabetic complications.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Mingzhe Zhu, Xue Wang, Kai Wang, Zhiqiang Zhao, Yanqi Dang, Guang Ji, Fenghua Li, Wenjun Zhou
Summary: The study found that Lingguizhugan decoction can partially alleviate non-alcoholic steatohepatitis by modulating gut microbiota and correlated metabolites. In an animal experiment, four weeks of Lingguizhugan decoction treatment improved the features of methionine- and choline-deficient diet-induced fatty liver disease, and also changed the relative abundance of gut microbial community and metabolites.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Plant Sciences
Yanping Jiang, Yongfeng Zheng, Qin Dong, Wan Liao, Lan Pang, Jiao Chen, Qinman He, Jinming Zhang, Yuanhong Luo, Jiaxin Li, Chaomei Fu, Qiang Fu
Summary: This study investigates the mechanism of Shentong Zhuyu decoction (STZYD) in the treatment of rheumatoid arthritis (RA) using network pharmacology and metabolomics. The results show that STZYD improves RA symptoms by regulating inflammation and immunity-related pathways and provides a new possibility for the treatment of RA.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Microbiology
Lili Zhang, Zhisheng Wang, Xiaona Zhang, Lu Zhao, Jinjin Chu, Haibo Li, Wenchang Sun, Chunjuan Yang, Hui Wang, Wenqing Dai, Shushan Yan, Xiaohua Chen, Donghua Xu
Summary: This study suggests that gut microbiota plays a critical role in the pathogenesis of diabetic nephropathy (DN). Although the exact mechanisms are still unclear, imbalances in gut microbiota have been observed in patients with type 2 diabetes mellitus (T2DM) and DN.
MICROBIOLOGY SPECTRUM
(2022)
Review
Medicine, General & Internal
Yan Zhang, Lijuan Jiang, Jiaojiao Xue, Minglong Lv, Wenfeng Zhang
Summary: This study found that Danggui Buxue Decoction (DGBXD) has significant efficacy in the treatment of diabetic nephropathy, and it improves clinical outcomes by modulating inflammatory factor levels. Furthermore, it identified 22 active ingredients and 209 active targets for DGBXD, and revealed that DGBXD affects diabetic nephropathy through a multi-target, multi-component, and multi-pathway mechanism.
Article
Chemistry, Medicinal
Xiaoyuan Guo, You Wu, Chengfei Zhang, Lili Wu, Lingling Qin, Tonghua Liu
Summary: This study investigated the pharmacological mechanisms of ZiShenWan (ZSW) in treating diabetic nephropathy using a network pharmacology approach. Results showed that ZSW achieved renoprotective effects by regulating multiple targets and signaling pathways, particularly by alleviating inflammation. Experimental validation in db/db mice confirmed the regulatory effects of ZSW on core targets and signaling pathways associated with inflammation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Microbiology
Hui Zhao, Cheng-E Yang, Tian Liu, Ming-Xia Zhang, Yan Niu, Ming Wang, Jun Yu
Summary: Diabetic nephropathy (DN) is a severe complication of diabetes, leading to renal failure and a significant global disease burden. The gut microbiota and its metabolites have been found to play a crucial role in the pathophysiology of DN through the gut-kidney axis. This review summarizes the current research on the involvement of gut microbiota and microbial metabolites in the progression of DN and explores potential therapeutic approaches targeting the gut microbiota.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Nutrition & Dietetics
Hongkang Zhu, Ruoyong Wang, Hanyi Hua, Yuliang Cheng, Yahui Guo, He Qian, Peng Du
Summary: Through network pharmacology and gut microbiota analysis, the multi-target mechanism of MCP in fatigue management was elucidated, which might be closely related to its prebiotic effect on intestinal bacteria.
Article
Chemistry, Medicinal
Mukaram Amatjan, Na Li, Pengke He, Boheng Zhang, Xianyan Mai, Qianle Jiang, Haochen Xie, Xiaoni Shao
Summary: This study showed that Cichorium intybus L. formula (CILF) can effectively alleviate kidney dysfunction and improve the diversity and community structure of gut microbiota in rats with hyperuricemic nephropathy (HN). Network pharmacology and molecular docking analysis revealed that CILF may exert its effects through modulating IL17, TNF, and AGE-RAGE signaling pathways.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Pharmacology & Pharmacy
Shu-Yue Qu, Xiao-Yue Li, Xia Heng, Yi-Yu Qi, Ping-Yuan Ge, Sai-jia Ni, Zeng-Ying Yao, Rui Guo, Nian-Yun Yang, Yi Cao, Qi-Chun Zhang, Hua-Xu Zhu
Summary: Depressive disorder is a prevalent mental disorder characterized by depressed mood and lack of interest or pleasure. Herbal medicine, such as Huang-lian Jie-du Decoction (HLJDD), has been explored as a complementary therapy for depression. This study demonstrates that HLJDD exhibits antidepressant effects by modulating tryptophan metabolism, serotonergic and dopaminergic synaptic activities, cAMP signaling pathway, and calcium signaling pathway, suggesting potential targets for its antidepressant action.
FRONTIERS IN PHARMACOLOGY
(2021)