Review
Cell Biology
Ruth E. Carmichael, Markus Islinger, Michael Schrader
Summary: Peroxisomes are dynamic organelles that can adjust their morphology and metabolic functions according to cellular needs. Their multiplication involves the coordination of several proteins, and defects in these proteins can lead to abnormal cellular dynamics and neurological defects.
Article
Cell Biology
Xiangyu Mao, Yihua Gu, Xiangyu Sui, Lei Shen, Jun Han, Haiyu Wang, Qiulei Xi, Qiulin Zhuang, Qingyang Meng, Guohao Wu
Summary: Patients with cachexia exhibit noticeable mitochondrial abnormalities and muscle loss, with an imbalance in mitochondrial dynamics potentially contributing to muscle atrophy. Regulation of DRP1 could ameliorate these abnormalities caused by cachexia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ammon E. Posey, Kyle A. Ross, Mehran Bagheri, Elizabeth N. Lanum, Misha A. Khan, Christine E. Jennings, Megan C. Harwig, Nolan W. Kennedy, Vincent J. Hilser, James L. Harden, R. Blake Hill
Summary: The variable domain (VD) of mitochondrial fission dynamin, dynamin-related protein 1, is shown to be intrinsically disordered and undergo a condensed liquid-like phase separation under crowding conditions. This condensed state involving the VD may enable rapid tuning of mechanoenzyme assembly necessary for fission.
Article
Cell Biology
Fernando Hernandez-Sanchez, Leonardo Peraza-Reyes
Summary: Eukaryotic cell development involves precise regulation of organelles to adapt to changing requirements. Meiotic development involves the formation and dynamics of distinct intracellular membrane compartments, and plays important roles in organelle segregation, quality control, and cell rejuvenation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Plant Sciences
Amanda K. Broz, Daniel B. Sloan, Iain G. Johnston
Summary: This study reveals the dynamics of organelle DNA (oDNA) segregation in Arabidopsis during development and reproduction. Using stochastic modeling, Bayesian inference, and new oDNA measurements, the study shows that oDNA segregation occurs gradually during plant development, with a more rapid increase between inflorescence formation and the next generation. The protein MSH1 plays a key role in accelerating oDNA segregation.
Article
Plant Sciences
Xiao-Le Wang, Si-Tong Feng, Ya-Ting Wang, Ning-Ning Zhang, Zhen-Yu Guo, Xu Yan, Yu-He Yuan, Zhen-Zhen Wang, Nai-Hong Chen, Yi Zhang
Summary: This study demonstrates that mangiferin can protect against Parkinson's disease by restoring mitochondrial ultrastructure and ATP levels, reducing Drp1 expression, and modulating mitophagic proteins in a mouse model of PD.
Article
Cell Biology
Lakhan Ekal, Abdulaziz M. S. Alqahtani, Ewald H. Hettema
Summary: Dynamin-related proteins (Drps) play a role in various membrane remodelling processes. The yeast Drp, Vps1, is involved in endocytosis, endosomal sorting, vacuole fusion, and peroxisome fission and breakdown. Our study highlights the specific requirement of peroxisomal membrane protein Pex27 for Vps1-dependent peroxisome fission in proliferating yeast cells. Pex27 interacts with Vps1 and affects peroxisome geometry. Pex27 is not involved in the association of Vps1 with pexophagophores during nitrogen starvation.
JOURNAL OF CELL SCIENCE
(2023)
Article
Critical Care Medicine
Riddhita Mukherjee, Carly A. Tompkins, Nicolai P. Ostberg, Amit U. Joshi, Liliana M. Massis, Vijith Vijayan, Kanika Gera, Denise Monack, Timothy T. Cornell, Mark W. Hall, Daria Mochly-Rosen, Bereketeab Haileselassie
Summary: This study reveals that inhibiting Drp1/Fis1-dependent mitochondrial fragmentation improves macrophage function and immune response in sepsis-induced immunoparalysis. This improvement is achieved by reducing the release of damaged extracellular mitochondria, which impacts endotoxin cross-tolerance. These findings suggest that alterations in mitochondrial dynamics play a crucial role in sepsis-induced immunoparalysis.
CRITICAL CARE MEDICINE
(2022)
Article
Cell Biology
Daqiang Wu, Yongkang Chu, Wenfan Wei, Ling Liu, Chuanhai Fu
Summary: This study used live-cell microscopy and an algorithm to quantitatively assess the mixing of parental mitochondria in fission yeast. The results showed that parental mitochondria mixed progressively during meiosis. The study also identified mitochondrial fission and the size of the conjugation neck as limiting factors in restricting mitochondrial mixing.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2022)
Review
Cell Biology
Chenxing Jiang, Tomohiko Okazaki
Summary: Peroxisomes are organelles that play a role in various metabolic pathways. Their biogenesis is controlled by a group of proteins, and mutations in these proteins can cause metabolic disorders. Recent research has shown that peroxisomes are involved in regulating cell apoptosis and fusion processes, and disruption of these processes may be related to the pathogenesis of specific diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Si-Tong Feng, Zhen-Zhen Wang, Yu-He Yuan, Xiao-Le Wang, Zhen-Yu Guo, Jing-Hong Hu, Xu Yan, Nai-Hong Chen, Yi Zhang
Summary: The inhibition of Drp1 improves motor deficits in a mouse model of Parkinson's disease, without affecting mitochondrial quantity or morphology. It also up-regulates mitochondrial expressions of PINK1 and Parkin.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Oncology
Yali Deng, Doan T. M. Ngo, Jessica K. Holien, Jarmon G. Lees, Shiang Y. Lim
Summary: Drp1 inhibition holds great potential as a targeted mitochondrial therapy for doxorubicin-induced cardiotoxicity, which is a significant challenge in clinical practice.
CURRENT ONCOLOGY REPORTS
(2022)
Review
Physiology
Ruth E. Carmichael, Michael Schrader
Summary: Organelle membranes are highly dynamic and exhibit plasticity, impacting the biogenesis and function of organelles. Understanding the dynamics of peroxisomal membranes is crucial for healthy cell function. Multidisciplinary research is needed to unravel the roles and regulation of peroxisome membrane dynamics.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Tina A. Schrader, Ruth E. Carmichael, Markus Islinger, Joseph L. Costello, Christian Hacker, Nina A. Bonekamp, Jochen H. Weishaupt, Peter M. Andersen, Michael Schrader
Summary: This study reveals a novel pathway for peroxisome division and identifies the role of FIS1 in peroxisome division.
JOURNAL OF CELL SCIENCE
(2022)
Article
Biology
Tricia T. Nguyen, Gia K. Voeltz
Summary: This study investigates how ER-associated mitochondrial nodes regulate the assembly of fission and fusion machinery on mitochondrial membranes. The researchers identified an ER membrane protein, ABHD16A, as a major regulator of node formation. The absence of ABHD16A results in the failure of fission and fusion machineries to recruit to the nodes, leading to decreased rates of fission and fusion.
Article
Mycology
Harumi Takano-Rojas, Denise Zickler, Leonardo Peraza-Reyes
Article
Biochemistry & Molecular Biology
Fernando Suaste-Olmos, Claudia Zirion-Martinez, Harumi Takano-Rojas, Leonardo Peraza-Reyes
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2018)
Article
Genetics & Heredity
Jinane Ait Benkhali, Evelyne Coppin, Sylvain Brun, Leonardo Peraza-Reyes, Tom Martin, Christina Dixelius, Noureddine Lazar, Herman van Tilbeurgh, Robert Debuchy
Review
Physiology
Leonardo Peraza-Reyes, Veronique Berteaux-Lecellier
FRONTIERS IN PHYSIOLOGY
(2013)
Article
Microbiology
Nallely Cano-Dominguez, Barry Bowman, Leonardo Peraza-Reyes, Jesus Aguirre
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Genetics & Heredity
Antonio de Jesus Lopez-Fuentes, Aldo Meizoso-Huesca, Leonardo Peraza-Reyes
FUNGAL GENETICS AND BIOLOGY
(2020)
Article
Mycology
S. Lorena Ament-Velasquez, Hanna Johannesson, Tatiana Giraud, Robert Debuchy, Sven J. Saupe, Alfons J. M. Debets, Eric Bastiaans, Fabienne Malagnac, Pierre Grognet, Leonardo Peraza-Reyes, Pierre Gladieux, Asa Kruys, Philippe Silar, Sabine M. Huhndorf, Andrew N. Miller, Aaron A. Vogan
Review
Microbiology
Raful Navarro-Espindola, Fernando Suaste-Olmos, Leonardo Peraza-Reyes
Article
Microbiology
Antonio de Jesus Lopez-Fuentes, Karime Naid Nachon-Garduno, Fernando Suaste-Olmos, Ariadna Mendieta-Romero, Leonardo Peraza-Reyes
Summary: This study demonstrates the involvement of the reticulon protein RTN1 in shaping the endoplasmic reticulum and aiding in the process of ascospore formation and nuclear segregation during sexual development in the model fungus Podospora anserina. The proper functioning and positioning of the spindle during meiosis rely on accurate dynamics of the ER membrane, with proteins such as RTN1 playing a key role in regulating nuclear dynamics.
Article
Cell Biology
Fernando Hernandez-Sanchez, Leonardo Peraza-Reyes
Summary: Eukaryotic cell development involves precise regulation of organelles to adapt to changing requirements. Meiotic development involves the formation and dynamics of distinct intracellular membrane compartments, and plays important roles in organelle segregation, quality control, and cell rejuvenation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Nutrition & Dietetics
Natali N. Guerrero-Vargas, Estefania Espitia-Bautista, Rene Escalona, Haydee Lugo-Martinez, Mariana Gutierrez-Perez, Raful Navarro-Espindola, Maria Fernanda Setien, Sebastian Boy-Waxman, Elizabeth Angelica Retana-Flores, Berenice Ortega, Ruud M. Buijs, Carolina Escobar
Summary: The study investigated the effect of timed restricted feeding on female rats exposed to light at night and found that scheduled feeding can restore daily rhythms of activity and temperature in these rats. Furthermore, the distribution of feeding pulses along the subjective night was more effective in restoring day-night activity, core temperature, and SCN function.
FRONTIERS IN NUTRITION
(2022)
Article
Oncology
Natali N. Guerrero-Vargas, Raful Navarro-Espindola, Mara A. Guzman-Ruiz, Maria del Carmen Basualdo, Estefania Espitia-Bautista, Ana Lopez-Bago, Ricardo Lascurain, Cinthya Cordoba-Manilla, Ruud M. Buijs, Carolina Escobar