Article
Endocrinology & Metabolism
Nina N. Sorensen, Christina M. Andreasen, Pia R. Jensen, Ellen M. Hauge, Jens Bollerslev, Jean-Marie Delaisse, Moustapha Kassem, Abbas Jafari, Marta Diaz-delCastillo, Thomas L. Andersen
Summary: This study found that increased cortisol production in patients with CS leads to increased bone marrow adiposity, primarily mediated by adipocyte hypertrophy. The differential pattern of adiposity in patients with CS and GC-O highlights that bone marrow adipocytes and their progenitors may respond differently in these two GC-mediated bone diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Julien Paccou, Sammy Badr, Daniela Lombardo, Huda Khizindar, Valerie Deken, Stefan Ruschke, Dimitrios C. Karampinos, Anne Cotten, Bernard Cortet
Summary: This study aimed to determine the association between proton density fat fraction (PDFF) and fractures. A case-control study was conducted on postmenopausal women, and it was found that MRI-based measurement of proximal femur PDFF can discriminate between postmenopausal women with and without clinical vertebral fractures, independent of age, CCI, and BMD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biotechnology & Applied Microbiology
Kai Feng, Mengyuan Yu, Xingyue Lou, Duo Wang, Lei Wang, Wenjie Ren
Summary: Osteoporosis is characterized by low bone mass and degradation of bone tissue microarchitecture, leading to increased bone fragility and fracture risk. Our study found that BMSCs from ovariectomized rats had higher osteogenic and lipogenic differentiation capacity compared to the control group. Proteomics and transcriptome analysis showed differential expression of proteins and genes mainly involved in ECM-receptor interaction signaling pathway. These findings provide new insights for further research on the pathogenesis of osteoporosis.
Article
Endocrinology & Metabolism
T. Dang, A. T. Faje, E. Meenaghan, M. A. Bredella, M. L. Bouxsein, A. Klibanski, P. K. Fazeli
Summary: This study found that although anorexia nervosa patients have decreased bone mineral density (BMD) and increased fracture risk, BMD does not predict fracture history in this disorder. On the other hand, bone marrow adipose tissue (BMAT) is associated with fracture history in these patients.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Psychiatry
Alexandra Loisel, Alexandra Caunes, Rudy Birsen, Marie Rose Moro, Ismael Boussaid, Corinne Blanchet
Summary: This case study presents a 15-year-old female patient with anorexia nervosa who suffered from severe pancytopenia, managed successfully with refeeding and active interventions.
EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
(2022)
Article
Endocrinology & Metabolism
Sammy Badr, Heloise Dapvril, Daniela Lombardo, Huda Khizindar, Claire Martin, Bernard Cortet, Anne Cotten, Julien Paccou
Summary: This study aimed to investigate the relationship between myosteatosis and bone marrow adiposity. The results showed that postmenopausal women with fragility fractures had higher fat content in the psoas and paravertebral muscles compared to the control group. However, there was no significant association between muscle myosteatosis and bone marrow adiposity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Shubhangi Tuli, Vibha Singhal, Meghan Slattery, Nupur Gupta, Kathryn S. Brigham, Jennifer Rosenblum, Seda Ebrahimi, Kamryn T. Eddy, Karen K. Miller, Madhusmita Misra
Summary: The bone outcomes of adolescent and young adult women with atypical anorexia nervosa (AAN) are characterized as intermediate between typical AN and normal-weight healthy controls (HC), indicating that AAN patients have a moderate level of bone impairment compared to AN patients and HC individuals.
Article
Biochemistry & Molecular Biology
Gang Wang, Lifu Wan, Lecheng Zhang, Chao Yan, Yuelei Zhang
Summary: This study found that miR-133a plays a role in regulating cell proliferation, osteoblast differentiation, and adipocyte differentiation of BMSCs by targeting FGFR1. BMSC-specific knockdown of miR-133a can attenuate bone loss.
DNA AND CELL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Ying Zhang, Xiangyang Cao, Peifeng Li, Yanan Fan, Leilei Zhang, Xianghao Ma, Ruibo Sun, Youwen Liu, Wuyin Li
Summary: The study demonstrates that BMSC-exo carrying miR-935 promotes osteoblast proliferation and differentiation through targeting STAT1.
Review
Endocrinology & Metabolism
Erica L. Scheller, Meghan E. McGee-Lawrence, Beata Lecka-Czernik
Summary: The BMA2020 meeting aimed to facilitate communication and collaboration among scientists worldwide interested in bone marrow adiposity research, attracting experts from various fields including bone biology, endocrinology, and stem cell biology.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Chermaine Hung, Marcus Munoz, Amal Shibli-Rahhal
Summary: Patients with anorexia nervosa often suffer from low bone mineral density and increased fracture risk, with weight restoration and resumption of menstrual function having the strongest impact on improving BMD. Other potential treatment options include bisphosphonates and teriparatide, although they are not approved for use in AN patients.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Ding Li, Qi Yuan, Liang Xiong, Aoyu Li, Yu Xia
Summary: The study identifies the role of the miR-4739/DLX3 axis in modulating the differentiation of BMSCs into osteoblasts, potentially contributing to the pathogenesis of osteoporosis. Further investigation is needed to understand the in vivo and clinical implications of this axis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Medicinal
Chenying Zeng, Shan Wang, Fenglei Chen, Ziming Wang, Jinteng Li, Zhongyu Xie, Mengjun Ma, Peng Wang, Huiyong Shen, Yanfeng Wu
Summary: This study demonstrates that alpinetin (APT) enhances osteogenic differentiation in BMSCs by activating the PKA/mTOR/ULK1 autophagy signaling pathway. These findings suggest a potential therapeutic application of APT for treating osteoporosis.
PHYTOTHERAPY RESEARCH
(2023)
Review
Endocrinology & Metabolism
Fangyu An, Xiaxia Wang, Chunmei Wang, Ying Liu, Bai Sun, Jie Zhang, Peng Gao, Chunlu Yan
Summary: Osteoporosis (OP) is characterized by imbalanced bone homeostasis due to decreased osteoblasts and increased adipocytes in the bone marrow compartment. Bone marrow mesenchymal stem cells (BMSCs) can differentiate into osteoblasts and adipocytes to maintain bone homeostasis. Studies have shown that the lncRNA-miRNA network plays a crucial role in regulating the bone/fat differentiation of BMSCs, which is closely related to the treatment of OP and the development of novel therapies. However, there is a limited summary of the effects of the lncRNA-miRNA network on osteogenic/adipogenic differentiation in BMSCs. Therefore, this article aims to review the current literature and explore the impact of the lncRNA-miRNA network on the osteogenic/adipogenic differentiation of BMSCs, providing a new theoretical basis for the treatment of OP.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Food Science & Technology
Ming Chen, Siqi Zhou, Kai Sun, Yongjun Hu, Haiyan Wen, Geliang Ren
Summary: Osteoporosis is a common metabolic disease in the elderly, causing a significant socioeconomic burden. This study investigated the protective effect of andrographolide (AGP) on glucocorticoid-induced osteoporosis (GIOP). The results showed that AGP alleviated the negative effects of glucocorticoid on BMSCs and promoted osteogenic differentiation through the activation of the PI3K/AKT pathway. In a GIOP mice model, AGP was also found to alleviate bone loss.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Rheumatology
Bernard Cortet, Stephanie Lucas, Isabelle Legroux-Gerot, Guillaume Penel, Christophe Chauveau, Julien Paccou
Article
Endocrinology & Metabolism
Nathalie Al Rassy, Ziad Bakouny, Joseph Matta, Fabienne Frenn, Ghassan Maalouf, Maroun Rizkallah, Falah Bachour, Amer Sebaaly, Pierre Hardouin, Christophe Chauveau, Rawad El Hage
JOURNAL OF BONE AND MINERAL METABOLISM
(2019)
Article
Endocrinology & Metabolism
Guillaume Penel, Greet Kerckhofs, Christophe Chauveau
FRONTIERS IN ENDOCRINOLOGY
(2019)
Review
Endocrinology & Metabolism
Nathalie Bravenboer, Miriam A. Bredella, Christophe Chauveau, Alessandro Corsi, Eleni Douni, William F. Ferris, Mara Riminucci, Pamela G. Robey, Shanti Rojas-Sutterlin, Clifford Rosen, Tim J. Schulz, William P. Cawthorn
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Loic Louvet, Damien Leterme, Severine Delplace, Flore Miellot, Pierre Marchandise, Veronique Gauthier, Pierre Hardouin, Christophe Chauveau, Olfa Ghali Mhenni
Article
Endocrinology & Metabolism
Alexandra Labarthe, Philippe Zizzari, Oriane Fiquet, Nicolas Lebrun, Johannes D. Veldhuis, Ferdinand Roelfsema, Christophe Chauveau, Mohammad Bohlooly-Y, Jacques Epelbaum, Virginie Tolle
Summary: The study reveals a sex-dependent dimorphic effect of GHS-R1a signaling on pulsatile GH secretion and meal pattern in mice, with different compensatory mechanisms occurring in the hypothalamus of adult males and females after GHS-R1a deletion. Altogether, the results demonstrate that GHS-R1a signaling plays a more critical role in regulating pulsatile GH secretion during adolescence in males and adulthood in females.
NEUROENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Philibert Duriez, Ida A. K. Nilsson, Ophelia Le Thuc, David Alexandre, Nicolas Chartrel, Carole Rovere, Christophe Chauveau, Philip Gorwood, Virginie Tolle, Odile Viltart
Summary: Anorexia nervosa is a severe eating disorder that may result in relapses even after treatment; research indicates that weight gain has an impact on the symptoms of patients with acute AN and partial recovery, with physical activity playing a key role in the recovery process.
Review
Endocrinology & Metabolism
Viktorija Avilkina, Christophe Chauveau, Olfa Ghali Mhenni
Summary: Mammalian sirtuins are crucial enzymes that regulate various biological processes and are well characterized in metabolic tissues. Their role in bone activity is important for maintaining bone homeostasis. Understanding the crosstalk between sirtuins, metabolic organs, and bone may contribute to the development of therapeutic strategies for metabolic diseases and osteoporosis.
Article
Endocrinology & Metabolism
Rim Hassouna, Gimena Fernandez, Nicolas Lebrun, Oriane Fiquet, Ferdinand Roelfsema, Alexandra Labarthe, Philippe Zizzari, Catherine Tomasetto, Jacques Epelbaum, Odile Viltart, Christophe Chauveau, Mario Perello, Virginie Tolle
Summary: Deletion of the preproghrelin gene has sex-specific effects on pulsatile GH secretion in adult mice, while having no impact on feeding, growth, or metabolic parameters.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Ayyoub Salmi, Federica Quacquarelli, Christophe Chauveau, Aline Clabaut, Odile Broux
Summary: This study investigated the interaction mechanisms between adipocytes and osteoblasts, identified multiple potential pathways, and explained how adipocytes influence osteoblast transdifferentiation.
Article
Endocrinology & Metabolism
Viktorija Avilkina, Damien Leterme, Guillaume Falgayrac, Jerome Delattre, Flore Miellot, Veronique Gauthier, Christophe Chauveau, Olfa Ghali Mhenni
Summary: This study demonstrates, for the first time, that the duration and severity of energy deficits are critical for changes in bone parameters, BMSC differentiation, and Sirt1 expression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jean-Guillaume Letarouilly, Julien Paccou, Sammy Badr, Christophe Chauveau, Odile Broux, Aline Clabaut
Summary: This study found that Tofa has a stimulatory effect on the commitment and differentiation of bone marrow adipocytes, but its effect on bone is not positive.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Josefine Tratwal, Guillaume Falgayrac, Alexandrine During, Nicolas Bertheaume, Charles Bataclan, Daniel N. N. Tavakol, Vasco Campos, Ludovic Duponchel, George Q. Q. Daley, Guillaume Penel, Christophe Chauveau, Olaia Naveiras
Summary: BMAds are the most abundant stromal component of adult human bone marrow, consisting of two types: rBMAds and cBMAds, with distinct characteristics. An in vitro model of BM adipogenesis with differential rBMAd and cBMAd-like characteristics has been developed, showing differences in fatty acid composition and desaturase expression. This model is useful for discriminating cBMAds from rBMAd and studying adipocyte differentiation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Laura Entz, Guillaume Falgayrac, Christophe Chauveau, Gilles Pasquier, Stephanie Lucas
Summary: This study found that bone marrow adipocytes (BMAds) do not impair osteoblastogenesis but do alter the quantity and quality of mineralization, partly depending on glucose concentration. This finding sheds light on the involvement of BMAds in compromised bone quality in patients with type 2 diabetes and osteoporosis.