Review
Biochemistry & Molecular Biology
Verena Petzer, Igor Theurl, Gunter Weiss, Dominik Wolf
Summary: Systemic iron overload in patients with MDS is multifactorial, mainly due to ineffective erythropoiesis and chronic red blood cell transfusion. Iron homeostasis varies among different MDS subtypes and its role in MDS is increasingly recognized. Genetic alterations, such as mutations in TET2, can lead to disturbances in iron homeostasis and hematopoiesis, highlighting the need for comprehensive understanding and development of future therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Masaya Iwamuro, Takehiro Tanaka, Motoyuki Otsuka
Summary: Recent studies have made significant progress in our understanding of autoimmune gastritis, particularly in identifying candidate genes involved in the development of pernicious anemia. Additional investigations have revealed insights into lymphocytes, cytokines, autoantibodies, and other factors related to the diagnosis and risk of gastric neoplasm. Furthermore, animal studies have explored the roles of roseolovirus and H. pylori in the onset and progression of the disease. Overall, these recent developments have provided valuable information on the pathophysiology and diagnosis of autoimmune gastritis.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pratik Thapa, Hong Jiang, Na Ding, Yanning Hao, Aziza Alshahrani, Eun Y. Lee, Junichi Fujii, Qiou Wei
Summary: Peroxiredoxin IV (Prx4) functions as an antioxidant to maintain cellular redox homeostasis. Loss of Prx4 leads to increased cell death and decreased infiltration of inflammatory cells in colon tumors. Targeting Prx4 may provide novel strategies for colon cancer prevention and treatment.
Article
Immunology
Xu Wang, Yuanmin Xu, Longfei Dai, Zhen Yu, Ming Wang, Shixin Chan, Rui Sun, Qijun Han, Jiajie Chen, Xiaomin Zuo, Zhenglin Wang, Xianyu Hu, Yang Yang, Hu Zhao, Kongwang Hu, Huabing Zhang, Wei Chen
Summary: In this study, a prognostic signature related to OFRG was developed and showed excellent performance in predicting survival and therapeutic responses for CRC patients. Low-risk CRC patients exhibited better prognosis, higher immune cell infiltration levels, and better responses to treatment compared to high-risk patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Physiology
Xiaoyu Zhao, Qiang Zhang, Rui Zheng
Summary: Autophagy is a crucial process for cell survival, development, and tissue balance. It protects cells against oxidative stress and injury. Dysregulated autophagy caused by factors like smoking and aging can lead to increased production of reactive oxygen species (ROS) and oxidative damage. ROS activates autophagy, which helps cells adapt and reduce damage by eliminating damaged molecules and organelles. Understanding the regulation of oxidative stress and autophagy is important in chronic obstructive pulmonary disease (COPD) research.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sonia Ben Hamouda, Khadija Essafi-Benkhadir
Summary: The study of tumor microenvironment (TME) in colorectal cancer (CRC) has become crucial as it is now understood that the interactions between tumor cells and the extracellular environment play a key role in tumor development. TME cells have both pro- and anti-tumor roles, and their interaction with tumor-infiltrating cells (TIC) leads to polarization and antagonist phenotypes. Understanding the complex signaling pathways and functions of TME components is of great interest for the development of personalized therapies for CRC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Physiology
Sanja Vignjevic Petrinovic, Maja S. Milosevic, Dragana Markovic, Sanja Momcilovic
Summary: Stress is both beneficial and detrimental to health, with chronic exposure to stress contributing to the development and progression of cancer. Chronic stress disrupts the communication between the neuroendocrine and immune systems, leading to inflammation and a decline in immune surveillance, which are implicated in cancer. Conversely, tumor-induced inflammation can adversely affect the stress response. This review focuses on the role of inflammation in stress-induced neuroendocrine-immune crosstalk and discusses the potential mechanisms for cancer treatment and prevention.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yingzi Wu, Jinhai Luo, Baojun Xu
Summary: This study identified the mechanism of geniposide in regulating oxidative stress in colorectal cancer (CRC) through network pharmacology and bioinformatics analysis. The study found that geniposide can regulate oxidative stress and may exert anti-CRC effects through multiple biological processes and signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Giuseppina Tesco, Selene Lomoio
Summary: Neurodegenerative diseases are characterized by the loss of specific neuronal populations and are associated with aging. Axonal transport and neuroinflammation play important roles in the pathogenesis of these diseases. However, the causal relationship between these mechanisms and neuronal degeneration is still uncertain. This article reviews the latest evidence on the interplay between axonal transport perturbations and CNS inflammation in neurodegenerative diseases, their potential as therapeutic targets, and the need for early biomarkers.
SEMINARS IN IMMUNOLOGY
(2022)
Article
Oncology
Teresa Catalano, Emira D'Amico, Carmelo Moscatello, Maria Carmela Di Marcantonio, Alessio Ferrone, Giuseppina Bologna, Federico Selvaggi, Paola Lanuti, Roberto Cotellese, Maria Cristina Curia, Rossano Lattanzio, Gitana Maria Aceto
Summary: The dysregulation of Wnt pathways in colorectal cancer is influenced by oxidative stress, leading to modulation of APC and beta-Catenin proteins. This study sheds light on the potential impact of oxidative distress on Wnt signaling functions in CRC and suggests avenues for developing personalized therapeutic approaches.
Article
Biochemistry & Molecular Biology
Sha Zhao, Chak Kwong Cheng, Cheng-Lin Zhang, Yu Huang
Summary: This review discusses the important role and interactions between oxidative stress, COXs, and prostanoids in cardiovascular diseases, highlighting recent advances in drug research and future directions for further studies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Livia Interdonato, Ylenia Marino, Rosalia Crupi, Enrico Gugliandolo, Francesco Macri, Davide Di Paola, Alessio Filippo Peritore, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: This study evaluated the modulation of autophagy, oxidative stress, and apoptosis with Acai Berries in a rat model of endometriosis. The results showed that Acai Berry inhibited the phosphorylation of PI3K, AKT, and ERK1/2, promoting autophagy, and exerted regulatory effects on cell apoptosis and oxidative stress.
Review
Biochemistry & Molecular Biology
Paulina Wigner, Radoslaw Grebowski, Michal Bijak, Joanna Saluk-Bijak, Janusz Szemraj
Summary: Bladder cancer is a dangerous disease, with men being at higher risk and risk factors including chemical exposure and genetic factors. Studies suggest that inflammation, oxidative stress, and angiogenesis disorders may promote the development of bladder cancer, and gene polymorphisms may affect the risk of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Nan Jiang, Xianxu Li, Qian Wang, Baikerouzi Baihetiyaer, Xiaoteng Fan, Mingsheng Li, Huimin Sun, Xianqiang Yin, Jun Wang
Summary: This study comprehensively investigated the ecotoxicological effects and potential mechanisms of propofol on zebrafish embryos. The results showed that propofol has moderate toxicity on zebrafish embryos, affecting their hatchability and development. Propofol can trigger reactive oxygen species generation, lipid peroxidation, DNA damage, and disturb the nervous system.
Article
Biology
Xiangkun Wu, Hong Yan, Mingxing Qiu, Xiaoping Qu, Jing Wang, Shaowan Xu, Yiran Zheng, Minghui Ge, Linlin Yan, Li Liang
Summary: Colorectal cancer (CRC) is a challenging and deadly disease with high tumor microenvironment (TME) heterogeneity. In this study, a comprehensive characterization of TME in colorectal cancer (CCCRC) was performed using integrative multi-omics analysis and artificial intelligence-enabled spatial analysis. Four CCCRC subtypes were identified with distinct TME features. These subtypes had different histopathologic and molecular characteristics, therapeutic efficacy, and prognosis. A simple gene classifier was also established for accurate identification of each CCCRC subtype. This study provides a holistic framework to dissect the TME of CRC and the CCCRC classification system may contribute to biomarker discovery and future clinical trial design.
Article
Biochemistry & Molecular Biology
Barbara Lanza, Martina Cellini, Sara Di Marco, Emira D'Amico, Nicola Simone, Lucia Giansante, Arianna Pompilio, Giuseppina Di Loreto, Martina Bacceli, Paolo Del Re, Giovanni Di Bonaventura, Luciana Di Giacinto, Gitana Maria Aceto
Article
Oncology
Teresa Catalano, Emira D'Amico, Carmelo Moscatello, Maria Carmela Di Marcantonio, Alessio Ferrone, Giuseppina Bologna, Federico Selvaggi, Paola Lanuti, Roberto Cotellese, Maria Cristina Curia, Rossano Lattanzio, Gitana Maria Aceto
Summary: The dysregulation of Wnt pathways in colorectal cancer is influenced by oxidative stress, leading to modulation of APC and beta-Catenin proteins. This study sheds light on the potential impact of oxidative distress on Wnt signaling functions in CRC and suggests avenues for developing personalized therapeutic approaches.
Review
Oncology
Federico Selvaggi, Teresa Catalano, Roberto Cotellese, Gitana Maria Aceto
Summary: The incidence and mortality of PLCs are steadily increasing worldwide, with limited treatment options. Understanding the molecular aspects of PLCs is crucial for developing more efficient drugs and therapeutic strategies.
Article
Cell Biology
Carmelo Moscatello, Maria Carmela Di Marcantonio, Luca Savino, Emira D'Amico, Giordano Spacco, Pasquale Simeone, Paola Lanuti, Raffaella Muraro, Gabriella Mincione, Roberto Cotellese, Gitana Maria Aceto
Summary: Thyroid diseases have a complex and multifactorial etiology. This study investigated the role of oxidative stress and the relationship between EGFR and OGG1-BER pathways in thyroid cancer development. The findings suggest that H2O2-induced oxidative stress may contribute to oxidative DNA damage and hyperactivation of related pathways in cancerous thyroid tissue. Additionally, dysregulation of the EGFR and OGG1-BER pathways was observed in a model of thyroid cancer with RET/PTC rearrangement.
Article
Oncology
Luca Savino, Maria Carmela Di Marcantonio, Carmelo Moscatello, Roberto Cotellese, Lucia Centurione, Raffaella Muraro, Gitana Maria Aceto, Gabriella Mincione
Summary: Gastric cancer is a significant health concern worldwide. The stomach is constantly exposed to oxidative stress, and the BER system plays a crucial role in defending against oxidative DNA damage. ErbB receptors are also involved in the pathogenesis of gastric cancer. Experimental findings suggest that oxidative stress can modulate the PI3K and MAPKs pathways, leading to a reduction in gastric cancer cell growth and migration.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Federico Selvaggi, Eugenia Melchiorre, Ilaria Casari, Sebastiano Cinalli, Massimiliano Cinalli, Gitana Maria Aceto, Roberto Cotellese, Ingrid Garajova, Marco Falasca
Summary: Pancreatic ductal adenocarcinoma is highly threatening and characterized by perineural invasion (PNI), which is associated with recurrence, poor prognosis, and pain. Researchers are currently seeking more effective therapies to inhibit the nerve invasion promoted by pancreatic ductal adenocarcinoma.
Review
Gastroenterology & Hepatology
Federico Selvaggi, Teresa Catalano, Rossano Lattanzio, Roberto Cotellese, Gitana Maria Aceto
Summary: The liver is the most common site of metastases in colorectal cancer patients. The development of colorectal liver metastases involves molecular mechanisms in the liver microenvironment, including the activation of the Wnt/beta-catenin pathway. However, the specific mechanisms and opportunities for anti-metastatic therapies are still not well understood. This review discusses the role of Wnt signaling in the development of colorectal liver metastases and provides an overview of current surgical and non-surgical treatments for patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Microbiology
Teresa Catalano, Federico Selvaggi, Diana Liberata Esposito, Roberto Cotellese, Gitana Maria Aceto
Summary: Interaction between infectious agents and liver tissue can lead to pathological conditions that predispose individuals to development of primary liver cancers (PLCs), including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). Infections such as hepatotropic viruses and oncogenic viruses can disrupt normal liver cell functions by affecting the Wnt/beta-catenin pathway. This review focuses on understanding how infectious agents can deregulate Wnt signaling and contribute to PLC development, and explores the potential of targeting the Wnt signaling pathway for novel therapeutic approaches.
Article
Polymer Science
Morena Petrini, Emira D'Amico, Tania Vanessa Pierfelice, Gitana Maria Aceto, Maryia Karaban, Pietro Felice, Adriano Piattelli, Antonio Barone, Giovanna Iezzi
Summary: This study aimed to test the effectiveness of a photodynamic protocol involving a gel with aminolevulinic acid and red LED irradiation (ALAD-PDT) on human gingival fibroblasts (hGFs) and osteoblasts (hOBs) cultured on a porcine acellular dermal matrix membrane (PADMM). Results showed that ALAD-PDT promoted cellular induction, forming a dense cellular network, with significantly higher values compared to LED alone and the control group.
Article
Surgery
Federico Selvaggi, Anna Cichella, Gitana Maria Aceto, Paolo Innocenti, Roberto Cotellese
Summary: Black esophagus, a rare condition that primarily affects adult males, presents with symptoms such as hematemesis, epigastric pain, and dysphagia. Treatment usually involves supportive therapy and hemodynamic resuscitation, with surgical intervention reserved for selected cases.
ANNALI ITALIANI DI CHIRURGIA
(2022)
Article
Oncology
Carmelo Moscatello, Marta Di Nicola, Serena Veschi, Patrizia Di Gregorio, Ettore Cianchetti, Liborio Stuppia, Pasquale Battista, Alessandro Cama, Maria Cristina Curia, Gitana Maria Aceto
Summary: The etiology of breast and ovarian cancer is multi-factorial, and the study investigated the correlation between germline mutation status and mRNA expression of BER genes (MUYTH and OGG1) with BRCA1 in patients. The results showed a significant correlation between gene expression and mutational spectrum, suggesting potential for genetic diagnosis and primary prevention in at-risk individuals.
MOLECULAR AND CLINICAL ONCOLOGY
(2021)
Review
Oncology
Maria Cristina Curia, Teresa Catalano, Gitana Maria Aceto
WORLD JOURNAL OF CLINICAL ONCOLOGY
(2020)
Meeting Abstract
Pathology
M. Mazzone, M. C. Di Marcantonio, R. Cotellese, L. Napolitano, E. D'Amico, G. Aceto, A. C. Frigo, R. Muraro, G. Mincione
JOURNAL OF MOLECULAR DIAGNOSTICS
(2020)
Meeting Abstract
Pathology
T. Catalano, M. C. Di Marcantonio, E. D'Amico, C. Moscatello, D. D'Agostino, G. Ferlazzo, G. Bologna, P. Lanuti, R. Lattanzio, M. C. Curiae, G. M. Aceto
JOURNAL OF MOLECULAR DIAGNOSTICS
(2020)