Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2
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Title
Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2
Authors
Keywords
Liver fibrosis, Gene expression, Mouse models, Gene regulation, Fatty liver, Liver diseases, Chromatin, Histones
Journal
PLoS Genetics
Volume 16, Issue 5, Pages e1008796
Publisher
Public Library of Science (PLoS)
Online
2020-05-20
DOI
10.1371/journal.pgen.1008796
References
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Note: Only part of the references are listed.- Polycomb Repressive Complex 2 Proteins EZH1 and EZH2 Regulate Timing of Postnatal Hepatocyte Maturation and Fibrosis by Repressing Gene Expression at Promoter Regions in Euchromatin in Mice
- (2019) Jessica Mae Grindheim et al. GASTROENTEROLOGY
- PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation
- (2019) Evan Healy et al. MOLECULAR CELL
- Oncogenic roles of enhancer of zeste homolog 1/2 in hematological malignancies
- (2018) Makoto Nakagawa et al. CANCER SCIENCE
- Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis
- (2018) Ying-Ying Lee et al. NUCLEIC ACIDS RESEARCH
- Impact of CAR Agonist Ligand TCPOBOP on Mouse Liver Chromatin Accessibility
- (2018) Nicholas J Lodato et al. TOXICOLOGICAL SCIENCES
- Integrating the Epigenome to Identify Novel Drivers of Hepatocellular Carcinoma
- (2018) R A Hlady et al. HEPATOLOGY
- Sexual dimorphism in hepatitis B and C and hepatocellular carcinoma
- (2018) Nico Buettner et al. Seminars in Immunopathology
- Activation of Male Liver Chromatin Accessibility and STAT5-Dependent Gene Transcription by Plasma Growth Hormone Pulses
- (2017) Jeannette Connerney et al. ENDOCRINOLOGY
- Gender differences in liver disease and the drug-dose gender gap
- (2017) Elena Buzzetti et al. PHARMACOLOGICAL RESEARCH
- Mechanisms Regulating PRC2 Recruitment and Enzymatic Activity
- (2017) Daniel Holoch et al. TRENDS IN BIOCHEMICAL SCIENCES
- The role of H19, a long non-coding RNA, in mouse liver postnatal maturation
- (2017) Chad Pope et al. PLoS One
- Role of Osteopontin in Liver Diseases
- (2016) Yankai Wen et al. International Journal of Biological Sciences
- Growth hormone: a newly identified developmental organizer
- (2016) Rajat K Das et al. JOURNAL OF ENDOCRINOLOGY
- The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival
- (2016) Sandra Mattu et al. JOURNAL OF HEPATOLOGY
- Liver-specific deletion of the signal transducer and activator of transcription 5 gene aggravates fatty liver in response to a high-fat diet in mice
- (2016) Myunggi Baik et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Targeting EZH2 in cancer
- (2016) Kimberly H Kim et al. NATURE MEDICINE
- An Animal Model for the Juvenile Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis
- (2016) Veronica Marin et al. PLoS One
- Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse
- (2016) Daniel Hanna et al. TOXICOLOGY
- Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice
- (2015) Jose Cordoba-Chacon et al. DIABETES
- The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration
- (2015) Woo Kyun Bae et al. FASEB JOURNAL
- Gender-specific postnatal demethylation and establishment of epigenetic memory
- (2015) Yitzhak Reizel et al. GENES & DEVELOPMENT
- Sex-Specific Differences in Hepatic Fat Oxidation and Synthesis May Explain the Higher Propensity for NAFLD in Men
- (2015) Camilla Pramfalk et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice
- (2015) Shiming Jiang et al. JOURNAL OF HEPATOLOGY
- Serum Golgi Protein 73 (GP73) is a Diagnostic and Prognostic Marker of Chronic HBV Liver Disease
- (2015) Zhengju Xu et al. MEDICINE
- Cross Talk Between GH-Regulated Transcription Factors HNF6 and CUX2 in Adult Mouse Liver
- (2015) Tara L. Conforto et al. MOLECULAR ENDOCRINOLOGY
- miR675 upregulates long noncoding RNA H19 through activating EGR1 in human liver cancer
- (2015) Haiyan Li et al. Oncotarget
- Regulation of gene transcription by Polycomb proteins
- (2015) S. Aranda et al. Science Advances
- EZH2 Represses Target Genes through H3K27-Dependent and H3K27-Independent Mechanisms in Hepatocellular Carcinoma
- (2014) Shu-Bin Gao et al. MOLECULAR CANCER RESEARCH
- Sex differences: Luck of the chromosomes
- (2014) Courtney Humphries NATURE
- Polycomb Group Protein Ezh2 Regulates Hepatic Progenitor Cell Proliferation and Differentiation in Murine Embryonic Liver
- (2014) Hiroyuki Koike et al. PLoS One
- Quantitative ChIP-Seq Normalization Reveals Global Modulation of the Epigenome
- (2014) David A. Orlando et al. Cell Reports
- featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
- (2013) Y. Liao et al. BIOINFORMATICS
- Long noncoding RNAs: Novel insights into hepatocelluar carcinoma
- (2013) Yong He et al. CANCER LETTERS
- Genome-Wide Analysis of Chromatin States Reveals Distinct Mechanisms of Sex-Dependent Gene Regulation in Male and Female Mouse Liver
- (2013) A. Sugathan et al. MOLECULAR AND CELLULAR BIOLOGY
- diffReps: Detecting Differential Chromatin Modification Sites from ChIP-seq Data with Biological Replicates
- (2013) Li Shen et al. PLoS One
- Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes
- (2013) James P Reddington et al. GENOME BIOLOGY
- Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins
- (2013) Sandy Leung-Kuen Au et al. Frontiers of Medicine
- Molecular Link between Liver Fibrosis and Hepatocellular Carcinoma
- (2013) Toshiharu Sakurai et al. Liver Cancer
- Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma
- (2012) Hashem B. El-Serag GASTROENTEROLOGY
- Impact of CUX2 on the Female Mouse Liver Transcriptome: Activation of Female-Biased Genes and Repression of Male-Biased Genes
- (2012) T. L. Conforto et al. MOLECULAR AND CELLULAR BIOLOGY
- Fast gapped-read alignment with Bowtie 2
- (2012) Ben Langmead et al. NATURE METHODS
- Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
- (2012) Cole Trapnell et al. Nature Protocols
- Sex-specific mouse liver gene expression: genome-wide analysis of developmental changes from pre-pubertal period to young adulthood
- (2012) Tara L Conforto et al. Biology of Sex Differences
- EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair
- (2011) E. Ezhkova et al. GENES & DEVELOPMENT
- Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice
- (2011) Kristina M. Mueller et al. HEPATOLOGY
- Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans
- (2011) Fu Yang et al. HEPATOLOGY
- Dynamic, Sex-Differential STAT5 and BCL6 Binding to Sex-Biased, Growth Hormone-Regulated Genes in Adult Mouse Liver
- (2011) Y. Zhang et al. MOLECULAR AND CELLULAR BIOLOGY
- The Polycomb complex PRC2 and its mark in life
- (2011) Raphaël Margueron et al. NATURE
- ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity
- (2011) Matthew D. Young et al. NUCLEIC ACIDS RESEARCH
- Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma
- (2011) B. Herquel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Unbiased, Genome-Wide In Vivo Mapping of Transcriptional Regulatory Elements Reveals Sex Differences in Chromatin Structure Associated with Sex-Specific Liver Gene Expression
- (2010) G. Ling et al. MOLECULAR AND CELLULAR BIOLOGY
- Intrinsic Sex Differences in the Early Growth Hormone Responsiveness of Sex-Specific Genes in Mouse Liver
- (2010) Valerie Wauthier et al. MOLECULAR ENDOCRINOLOGY
- A unique chromatin signature uncovers early developmental enhancers in humans
- (2010) Alvaro Rada-Iglesias et al. NATURE
- GREAT improves functional interpretation of cis-regulatory regions
- (2010) Cory Y McLean et al. NATURE BIOTECHNOLOGY
- Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes
- (2010) Diego Pasini et al. NUCLEIC ACIDS RESEARCH
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
- (2009) M. D. Robinson et al. BIOINFORMATICS
- Male-Specific Hepatic Bcl6: Growth Hormone-Induced Block of Transcription Elongation in Females and Binding to Target Genes Inversely Coordinated with STAT5
- (2009) Rosana D. Meyer et al. MOLECULAR ENDOCRINOLOGY
- Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes
- (2009) D. J. Waxman et al. MOLECULAR PHARMACOLOGY
- Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms
- (2008) Raphael Margueron et al. MOLECULAR CELL
- Model-based Analysis of ChIP-Seq (MACS)
- (2008) Yong Zhang et al. GENOME BIOLOGY
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