Sequence-based prediction of protein binding mode landscapes

Packing of apolar side chains enables accurate design of highly stable membrane proteins

(2019) Marco Mravic et al.   SCIENCE

Structural Basis of Protein Kinase R Autophosphorylation

(2019) Christopher B. Mayo et al.   BIOCHEMISTRY

Fuzziness in Protein Interactions—A Historical Perspective

(2018) Monika Fuxreiter   JOURNAL OF MOLECULAR BIOLOGY

Structural Ensemble Modulation upon Small-Molecule Binding to Disordered Proteins

(2018) Gabriella T. Heller et al.   JOURNAL OF MOLECULAR BIOLOGY

Deciphering the Dynamic Interaction Profile of an Intrinsically Disordered Protein by NMR Exchange Spectroscopy

(2018) Elise Delaforge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

Extreme disorder in an ultrahigh-affinity protein complex

(2018) Alessandro Borgia et al.   NATURE

Fold or not to fold upon binding — does it really matter?

(2018) Monika Fuxreiter   CURRENT OPINION IN STRUCTURAL BIOLOGY

Fuzziness enables context dependence of protein interactions

(2017) Marton Miskei et al.   FEBS LETTERS

Simultaneous quantification of protein order and disorder

(2017) Pietro Sormanni et al.   Nature Chemical Biology

The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules

(2016) Hao Wu et al.   CELL

The coming of age of de novo protein design

(2016) Po-Ssu Huang et al.   NATURE

FuzDB: database of fuzzy complexes, a tool to develop stochastic structure-function relationships for protein complexes and higher-order assemblies

(2016) Marton Miskei et al.   NUCLEIC ACIDS RESEARCH

Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein

(2016) Angelo Toto et al.   Scientific Reports

Protein design: Past, present, and future

(2015) Lynne Regan et al.   BIOPOLYMERS

Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

(2015) Aashish Manglik et al.   CELL

Short linear motifs – ex nihilo evolution of protein regulation

(2015) Norman E. Davey et al.   Cell Communication and Signaling

Structural Basis of Ribosomal S6 Kinase 1 (RSK1) Inhibition by S100B Protein

(2015) Gergő Gógl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Computational design of co-assembling protein–DNA nanowires

(2015) Yun Mou et al.   NATURE

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

(2015) Han Dai et al.   Nature Communications

Compensatory Adaptations of Structural Dynamics in an Intrinsically Disordered Protein Complex

(2014) Dennis Kurzbach et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DISOPRED3: precise disordered region predictions with annotated protein-binding activity

(2014) David T. Jones et al.   BIOINFORMATICS

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

A Million Peptide Motifs for the Molecular Biologist

(2014) Peter Tompa et al.   MOLECULAR CELL

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

(2014) Alaji Bah et al.   NATURE

Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6

(2014) Jennifer L Stamos et al.   eLife

Allostery in Disease and in Drug Discovery

(2013) Ruth Nussinov et al.   CELL

The Dynamic Process of β2-Adrenergic Receptor Activation

(2013) Rie Nygaard et al.   CELL

Interaction of the Eukaryotic Initiation Factor 4E with 4E-BP2 at a Dynamic Bipartite Interface

(2013) Sabelo Lukhele et al.   STRUCTURE

From protein sequence to dynamics and disorder with DynaMine

(2013) Elisa Cilia et al.   Nature Communications

Interactions via intrinsically disordered regions: What kind of motifs?

(2012) Rita Pancsa et al.   IUBMB LIFE

HMGB1-Facilitated p53 DNA Binding Occurs via HMG-Box/p53 Transactivation Domain Interaction, Regulated by the Acidic Tail

(2012) John P. Rowell et al.   STRUCTURE

Leukemia Fusion Target AF9 Is an Intrinsically Disordered Transcriptional Regulator that Recruits Multiple Partners via Coupled Folding and Binding

(2012) Benjamin I. Leach et al.   STRUCTURE

ESpritz: accurate and fast prediction of protein disorder

(2011) Ian Walsh et al.   BIOINFORMATICS

Fuzziness: linking regulation to protein dynamics

(2011) Monika Fuxreiter   Molecular BioSystems

Replication through an abasic DNA lesion: structural basis for adenine selectivity

(2010) Samra Obeid et al.   EMBO JOURNAL

Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation

(2010) C. W. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Close encounters of the third kind: disordered domains and the interactions of proteins

(2009) Peter Tompa et al.   BIOESSAYS

Linking folding and binding

(2009) Peter E Wright et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

(2009) Marcello Clerici et al.   EMBO JOURNAL

Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein

(2009) J. C. Ferreon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The unfolded protein response signals through high-order assembly of Ire1

(2008) Alexei V. Korennykh et al.   NATURE

Fuzzy complexes: polymorphism and structural disorder in protein–protein interactions

(2007) Peter Tompa et al.   TRENDS IN BIOCHEMICAL SCIENCES