A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination

Spotting the old foe—revisiting the case definition for TB

(2019) Rein M G J Houben et al.   Lancet Respiratory Medicine

Fluoroquinolone efficacy against tuberculosis is driven by penetration into lesions and activity against resident bacterial populations

(2019) Jansy Sarathy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Boosting BCG with proteins or rAd5 does not enhance protection against tuberculosis in rhesus macaques

(2019) Patricia A. Darrah et al.   npj Vaccines

Growth ofMycobacterium tuberculosisin vivo segregates with host macrophage metabolism and ontogeny

(2018) Lu Huang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Emergence and selection of isoniazid and rifampin resistance in tuberculosis granulomas

(2018) Elsje Pienaar et al.   PLoS One

Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques

(2018) Anthony M. Cadena et al.   PLoS Pathogens

Bayesian Methods for Calibrating Health Policy Models: A Tutorial

(2017) Nicolas A. Menzies et al.   PHARMACOECONOMICS

Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis

(2017) Constance J. Martin et al.   mBio

Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model

(2017) Hayley C. Warsinske et al.   Frontiers in Immunology

Effects of B Cell Depletion on Early Mycobacterium tuberculosis Infection in Cynomolgus Macaques

(2016) Jiayao Phuah et al.   INFECTION AND IMMUNITY

Computational and Empirical Studies Predict Mycobacterium tuberculosis-Specific T Cells as a Biomarker for Infection Outcome

(2016) Simeone Marino et al.   PLoS Computational Biology

PET CT Identifies Reactivation Risk in Cynomolgus Macaques with Latent M. tuberculosis

(2016) Philana Ling Lin et al.   PLoS Pathogens

Local Inflammation, Dissemination and Coalescence of Lesions Are Key for the Progression toward Active Tuberculosis: The Bubble Model

(2016) Clara Prats et al.   Frontiers in Microbiology

Immunology studies in non-human primate models of tuberculosis

(2015) JoAnne L. Flynn et al.   IMMUNOLOGICAL REVIEWS

A multi-scale approach to designing therapeutics for tuberculosis

(2015) Jennifer J. Linderman et al.   Integrative Biology

A New Initiative on Precision Medicine

(2015) Francis S. Collins et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD8 T cells and Mycobacterium tuberculosis infection

(2015) Philana Ling Lin et al.   Seminars in Immunopathology

Variability in Tuberculosis Granuloma T Cell Responses Exists, but a Balance of Pro- and Anti-inflammatory Cytokines Is Associated with Sterilization

(2015) Hannah Priyadarshini Gideon et al.   PLoS Pathogens

Strategies for Efficient Numerical Implementation of Hybrid Multi-scale Agent-Based Models to Describe Biological Systems

(2014) Nicholas A. Cilfone et al.   Cellular and Molecular Bioengineering

Early Changes by 18Fluorodeoxyglucose Positron Emission Tomography Coregistered with Computed Tomography Predict Outcome after Mycobacterium tuberculosis Infection in Cynomolgus Macaques

(2014) M. T. Coleman et al.   INFECTION AND IMMUNITY

Computational Modeling Predicts IL-10 Control of Lesion Sterilization by Balancing Early Host Immunity–Mediated Antimicrobial Responses with Caseation duringMycobacterium tuberculosisInfection

(2014) Nicholas A. Cilfone et al.   JOURNAL OF IMMUNOLOGY

scikit-image: image processing in Python

(2014) Stéfan van der Walt et al.   PeerJ

Radiologic Responses in Cynomolgus Macaques for Assessing Tuberculosis Chemotherapy Regimens

(2013) Philana Ling Lin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mycobacterium tuberculosis-specific CD8+T cells are functionally and phenotypically different between latent infection and active disease

(2013) Virginie Rozot et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing

(2013) Philana Ling Lin et al.   NATURE MEDICINE

The Roles of Immune Memory and Aging in Protective Immunity and Endogenous Reactivation of Tuberculosis

(2013) Giorgio Guzzetta et al.   PLoS One

Multi-Scale Modeling Predicts a Balance of Tumor Necrosis Factor-α and Interleukin-10 Controls the Granuloma Environment during Mycobacterium tuberculosis Infection

(2013) Nicholas A. Cilfone et al.   PLoS One

NF-κB Signaling Dynamics Play a Key Role in Infection Control in Tuberculosis

(2012) Mohammad Fallahi-Sichani et al.   Frontiers in Physiology

Double- and monofunctional CD4+ and CD8+ T-cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long-term latently infected individuals

(2011) Susanna Commandeur et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Latent tuberculosis: what the host “sees”?

(2011) Hannah P. Gideon et al.   IMMUNOLOGIC RESEARCH

Multiscale Computational Modeling Reveals a Critical Role for TNF-  Receptor 1 Dynamics in Tuberculosis Granuloma Formation

(2011) M. Fallahi-Sichani et al.   JOURNAL OF IMMUNOLOGY

Simian Immunodeficiency Virus-Induced Changes in T Cell Cytokine Responses in Cynomolgus Macaques with Latent Mycobacterium tuberculosis Infection Are Associated with Timing of Reactivation

(2011) J. T. Mattila et al.   JOURNAL OF IMMUNOLOGY

The role of IL-10 in immune regulation during M. tuberculosis infection

(2011) P S Redford et al.   Mucosal Immunology

A multifaceted approach to modeling the immune response in tuberculosis

(2011) Simeone Marino et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

TNF and IL-10 are major factors in modulation of the phagocytic cell environment in lung and lymph node in tuberculosis: A next-generation two-compartmental model

(2010) Simeone Marino et al.   JOURNAL OF THEORETICAL BIOLOGY

Reactivation of Latent Tuberculosis in Cynomolgus Macaques Infected with SIV Is Associated with Early Peripheral T Cell Depletion and Not Virus Load

(2010) Collin R. Diedrich et al.   PLoS One

Quantitative Comparison of Active and Latent Tuberculosis in the Cynomolgus Macaque Model

(2009) P. L. Lin et al.   INFECTION AND IMMUNITY

A methodology for performing global uncertainty and sensitivity analysis in systems biology

(2008) Simeone Marino et al.   JOURNAL OF THEORETICAL BIOLOGY