Nonpeptidic Selective Inhibitors of the Chymotrypsin-Like (β5 i) Subunit of the Immunoproteasome

Identification of a β1/β2-Specific Sulfonamide Proteasome Ligand by Crystallographic Screening

(2015) Philipp Beck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective Inhibition of the Immunoproteasome by Ligand-Induced Crosslinking of the Active Site

(2014) Christian Dubiella et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective immunoproteasome inhibitors with non-peptide scaffolds identified from structure-based virtual screening

(2014) Vinod Kasam et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Subunit specific inhibitors of proteasomes and their potential for immunomodulation

(2014) Alexei F Kisselev et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Interferon-γ-induced upregulation of immunoproteasome subunit assembly overcomes bortezomib resistance in human hematological cell lines

(2014) Denise Niewerth et al.   Journal of Hematology & Oncology

Structure-Based Design of β1i or β5i Specific Inhibitors of Human Immunoproteasomes

(2014) Gerjan de Bruin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome

(2014) Hao Fan et al.   ACS Medicinal Chemistry Letters

Inhibitors for the Immuno- and Constitutive Proteasome: Current and Future Trends in Drug Development

(2012) Eva Maria Huber et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity

(2012) Eva M. Huber et al.   CELL

Drug discovery for a new generation of covalent drugs

(2012) Amit S Kalgutkar et al.   Expert Opinion on Drug Discovery

Molecular and Cellular Characterization of the Biological Effects of Ruthenium(II) Complexes Incorporating 2-Pyridyl-2-pyrimidine-4-carboxylic Acid

(2012) Vanessa Pierroz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The resurgence of covalent drugs

(2011) Juswinder Singh et al.   NATURE REVIEWS DRUG DISCOVERY

Prevention of Experimental Colitis by a Selective Inhibitor of the Immunoproteasome

(2010) M. Basler et al.   JOURNAL OF IMMUNOLOGY

The 26S proteasome: assembly and function of a destructive machine

(2010) Nerea Gallastegui et al.   TRENDS IN BIOCHEMICAL SCIENCES

Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome

(2009) F. Parlati et al.   BLOOD

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

(2009) Tony Muchamuel et al.   NATURE MEDICINE

Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors

(2008) Deborah J. Kuhn et al.   BLOOD