Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ1−42Aggregation Inhibitors for Alzheimer's Disease Therapy

Donepezil–ferulic acid hybrids as anti-Alzheimer drugs

(2015) Mohamed Benchekroun et al.   Future Medicinal Chemistry

The burden of disease in older people and implications for health policy and practice

(2015) Martin J Prince et al.   LANCET

Synthesis, Biological Evaluation, and Computational Studies of Tri- and Tetracyclic Nitrogen-Bridgehead Compounds as Potent Dual-Acting AChE Inhibitors and hH3 Receptor Antagonists

(2014) Fouad H. Darras et al.   ACS Chemical Neuroscience

Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with ‘inverted’ binding mode

(2014) Fouad H. Darras et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel Tacrine-Grafted Ugi Adducts as Multipotent Anti-Alzheimer Drugs: A Synthetic Renewal in Tacrine-Ferulic Acid Hybrids

(2014) Mohamed Benchekroun et al.   ChemMedChem

Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer’s Disease

(2014) Angel Agis-Torres et al.   Current Neuropharmacology

Highly efficient organocatalytic synthesis of diverse and densely functionalized 2-amino-3-cyano-4H-pyrans under mechanochemical ball milling

(2014) Mohammad G. Dekamin et al.   GREEN CHEMISTRY

New multi-target-directed small molecules against Alzheimer's disease: a combination of resveratrol and clioquinol

(2014) Fei Mao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A water–ethanol on–off fiber catalyst for the synthesis of substituted 2-amino-2-chromenes

(2014) Yazhi Zhen et al.   RSC Advances

Synthesis and biological evaluation of lycorine derivatives as dual inhibitors of human acetylcholinesterase and butyrylcholinesterase

(2012) Yue-Hu Wang et al.   Chemistry Central Journal

Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease

(2012) Emna Maalej et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands

(2012) Jonah Cheung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines

(2011) Emna Maalej et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hybrid-Based Multi-Target Ligands for the Treatment of Alzheimer's Disease

(2011) Angela Rampa et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

MiniMuDS: A New Optimizer using Knowledge-Based Potentials Improves Scoring of Docking Solutions

(2011) Andreas Spitzmüller et al.   Journal of Chemical Information and Modeling

DSX: A Knowledge-Based Scoring Function for the Assessment of Protein–Ligand Complexes

(2011) Gerd Neudert et al.   Journal of Chemical Information and Modeling

Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease

(2011) Rafael León et al.   MEDICINAL RESEARCH REVIEWS

Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors

(2010) Xinyu Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Recent advances in multicomponent reactions for diversity-oriented synthesis

(2010) James E. Biggs-Houck et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists

(2010) Isabelle Tomassoli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution

(2010) Harry Levine   PROTEIN SCIENCE

Designing Multiple Ligands – Medicinal Chemistry Strategies and Challenges

(2009) Richard Morphy et al.   CURRENT PHARMACEUTICAL DESIGN

Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties

(2008) Michael Decker et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of tacrine–ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates

(2008) Lei Fang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY