Long-term safety and tolerability of atabecestat (JNJ-54861911), an oral BACE1 inhibitor, in early Alzheimer’s disease spectrum patients: a randomized, double-blind, placebo-controlled study and a two-period extension study

Lowering of Amyloid-Beta by β-Secretase Inhibitors — Some Informative Failures

(2019) David S. Knopman   NEW ENGLAND JOURNAL OF MEDICINE

Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer’s Disease

(2019) David Henley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease

(2019) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alzheimer’s Disease: Advances in Drug Development

(2018) Morgane Piton et al.   JOURNAL OF ALZHEIMERS DISEASE

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease

(2018) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacodynamics of atabecestat (JNJ-54861911), an oral BACE1 inhibitor in patients with early Alzheimer’s disease: randomized, double-blind, placebo-controlled study

(2018) Maarten Timmers et al.   Alzheimers Research & Therapy

Clinical Evaluation of Amyloid-Related Imaging Abnormalities in Bapineuzumab Phase III Studies

(2018) H. Robert Brashear et al.   JOURNAL OF ALZHEIMERS DISEASE

Memory self-awareness in the preclinical and prodromal stages of Alzheimer’s disease

(2017) Patrizia Vannini et al.   NEUROPSYCHOLOGIA

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease

(2016) Soraia Barão et al.   TRENDS IN NEUROSCIENCES

Impact of frequent cerebrospinal fluid sampling on Aβ levels: systematic approach to elucidate influencing factors

(2016) Bianca Van Broeck et al.   Alzheimers Research & Therapy

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein

(2016) Saoussen Ben Halima et al.   Cell Reports

Stepping closer to treating Alzheimer’s disease patients with BACE1 inhibitor drugs

(2016) Riqiang Yan   Translational Neurodegeneration

Measuring brain atrophy with a generalized formulation of the boundary shift integral

(2015) Ferran Prados et al.   NEUROBIOLOGY OF AGING

Accuracy of Brain Amyloid Detection in Clinical Practice Using Cerebrospinal Fluid β-Amyloid 42

(2014) Sebastian Palmqvist et al.   JAMA Neurology

BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells

(2013) L. Rochin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Liver involvement in subjects with rheumatic disease

(2011) Carlo Selmi et al.   ARTHRITIS RESEARCH & THERAPY