Review
Materials Science, Biomaterials
Jianmin Xue, Chen Qin, Chengtie Wu
Summary: The combination of biomaterials and living cells in tissue engineering has shown unique advantages in tissue regeneration. The advancement of 3D printing technology has further enhanced the design and composition of tissue engineering scaffolds, allowing for easier loading and delivery of living cells.
REGENERATIVE BIOMATERIALS
(2023)
Article
Engineering, Biomedical
Sung Yun Hann, Haitao Cui, Timothy Esworthy, Xuan Zhou, Se-jun Lee, Michael W. Plesniak, Lijie Grace Zhang
Summary: The development of vascular networks is crucial for tissue fabrication in regenerative medicine. 3D printing vascularized bone has gained attention due to bone disorders, but challenges persist due to the need for nanoscale precision. A novel 3D printing approach was combined with biocompatible materials to enhance vascular growth and tissue bioactivity.
ACTA BIOMATERIALIA
(2021)
Article
Nanoscience & Nanotechnology
Pengfei Cai, Chunchun Li, Yangfan Ding, Hanting Lu, Xiao Yu, Jie Cui, Fan Yu, Hongsheng Wang, Jinglei Wu, Mohamed EL-Newehy, Meera Moydeen Abdulhameed, Liang Song, Xiumei Mo, Binbin Sun
Summary: This research introduces a novel method that combines electrospun nanofibers with 3D printing techniques to fabricate composite scaffolds for bone defect treatment. Compared to nanoparticle-reinforced scaffolds, these scaffolds infused with nanofibers exhibit superior mechanical attributes and bioactivity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Engineering, Biomedical
Hongjian Zhang, Chengtie Wu
Summary: Neurovascular networks play important roles in tissue and organ regeneration. Traditional scaffolds cannot meet the requirement of angiogenesis and innervation, but 3D printing provides a versatile technique to fabricate biomimetic scaffolds. This review summarizes the progress in using 3D-printed biomaterials for vascularized and innervated tissue regeneration.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Engineering, Biomedical
Vincent Fitzpatrick, Zaira Martin-Moldes, Anna Deck, Ruben Torres-Sanchez, Anne Valat, Dana Cairns, Chunmei Li, David L. Kaplan
Summary: The study aimed to use functionalized 3D-printed scaffolds for bone regeneration, incorporating silk-hydroxyapatite bone cements and various growth factors. Functionalities were assessed through cellular differentiation, migration, and proliferation, identifying synergistic effects among the growth factors.
Article
Engineering, Biomedical
Yuchen Tian, Hongshi Ma, Xiaopeng Yu, Boshi Feng, Zhibo Yang, Wei Zhang, Chengtie Wu
Summary: Repairing critical-size bone defects is a challenging task in clinical practice, and early-stage vascularization is crucial for bone regeneration. This study utilized 3D printing technology to create beta-tricalcium phosphate bioceramic scaffolds with a hollow tube structure, which demonstrated superior osteogenic and angiogenic properties compared to solid scaffolds. These scaffolds have great potential for the treatment of critical-size bone defects.
BIOMEDICAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Naren Raja, Shi Huan Han, Minjoon Cho, Yeong-Jin Choi, Yuan-Zhe Jin, Honghyun Park, Jae Hyup Lee, Hui-suk Yun
Summary: Highly porous calcium phosphate (CaP) scaffolds with multiple phases were fabricated using a combination of 3D printing, salt-leaching, and bone cement chemistry. The composite scaffolds showed improved compressive strength and biodegradability, making them suitable for bone tissue regeneration.
MATERIALS & DESIGN
(2022)
Article
Engineering, Biomedical
Qiang Zhang, Ho-Pan Bei, Mengna Zhao, Zhifei Dong, Xin Zhao
Summary: This article provides an overview of recent advances in the promising development of photo-crosslinkable materials for 3D printing, with a focus on their biomedical applications for repairing damaged organs and developing in vitro tissue models. By selecting appropriate ink combinations or modulating the photo-crosslinking printing parameters, the structures and properties of the printed scaffolds can be finely tailored to meet practical application requirements.
Article
Engineering, Biomedical
Boshi Feng, Meng Zhang, Chen Qin, Dong Zhai, Yufeng Wang, Yanling Zhou, Jiang Chang, Yufang Zhu, Chengtie Wu
Summary: Inspired by the physiological features of conches, researchers successfully developed a conch-like scaffold using 3D printing technology. This scaffold, with its spiral structure, significantly improved cell adhesion, proliferation, and osteogenic differentiation. The scaffold efficiently guided cells to grow upward, and the capability of guiding directional bone growth was demonstrated in an animal model.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Wei-Jia Huang, Jane Wang
Summary: In this study, a promising material poly (glycerol sebacate) acrylate (PGSA) with tunable mechanical properties and biocompatibility was used, and it was embedded with polyvinylpyrrolidone (PVP), silver nanoparticles (AgNPs), and graphene to fabricate microstructured nerve conduits. The results showed that the PGSA composites exhibited high conductivity, good biodegradability, and promoted cell proliferation. Therefore, 3D-printed nerve conduits fabricated with PGSA composites hold great potential in nerve tissue regeneration.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Polymer Science
Hun-Jin Jeong, Se-Won Lee, Myoung Wha Hong, Young Yul Kim, Kyoung Duck Seo, Young-Sam Cho, Seung-Jae Lee
Summary: The study created a polycaprolactone-based patient-specific designed hybrid-scaffold using 3D printing, which successfully regenerated the meniscus and showed superior shape matching and cell ingrowth in experiments.
Review
Biotechnology & Applied Microbiology
Zhen Yang, Jianwei Li, Haoyuan Deng, Hao Li, Tianyuan Zhao, Tianze Gao, Dan Xing, Jianhao Lin
Summary: 3D printing technology offers hope for the repair and regeneration of cartilage defects, but research in this area is still limited. Through bibliometric analysis, we summarized the research status of 3D printing technology and cartilage repair and regeneration from 2002 to 2022. Based on the analysis, we discussed the current advantages, limitations, and future development prospects in this field, aiming to guide researchers and promote clinical application.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Physical
Javier Montero, Alicia Becerro, Beatriz Pardal-Pelaez, Norberto Quispe-Lopez, Juan-Francisco Blanco, Cristina Gomez-Polo
Summary: This study reviews the existing methods for manufacturing customized bone scaffolds, identifying 14 different techniques. Conventional techniques are limited in controlling pore architecture and interconnection, while current Solid Freeform Fabrication techniques allow for individualized complex pore geometries. Promising options in customized bone regeneration currently include SLA, Robocasting, and FDM.
Review
Materials Science, Multidisciplinary
Amir A. Elhadad, Ana Rosa-Sainz, Raquel Canete, Estela Peralta, Belen Begines, Mario Balbuena, Ana Alcudia, Y. Torres
Summary: This article explores recent advancements and emerging trends in 3D printing from a novel multidisciplinary perspective. It provides an overview of various 3D printing techniques and their applications, with a focus on materials such as composites, hybrids, and smart materials. The article also discusses the latest developments in 4D bioprinting technology and outlines present challenges and future regulations.
MATERIALS SCIENCE & ENGINEERING R-REPORTS
(2023)
Article
Materials Science, Multidisciplinary
Boqing Zhang, Ling Wang, Ping Song, Xuan Pei, Huan Sun, Lina Wu, Changchun Zhou, Kefeng Wang, Yujiang Fan, Xingdong Zhang
Summary: This study successfully combined PLLH/nHA composite with FDM technology to prepare porous bone repair scaffolds. The scaffolds showed good printing smoothness and accuracy, suitable mechanical properties, and good osteogenic properties.
MATERIALS & DESIGN
(2021)
Article
Engineering, Biomedical
Tian Li, Bing Ma, Jianmin Xue, Dong Zhai, Pengyu Zhao, Jiang Chang, Chengtie Wu
ADVANCED HEALTHCARE MATERIALS
(2020)
Article
Materials Science, Multidisciplinary
Pengyu Zhao, Yaqin Liu, Tian Li, Yanling Zhou, Sander Leeflang, Lei Chen, Chengtie Wu, Jie Zhou, Zhiguang Huan
PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL
(2020)
Article
Chemistry, Multidisciplinary
Mengmeng Li, Hongshi Ma, Fei Han, Dong Zhai, Bingjun Zhang, Yuhua Sun, Tian Li, Lei Chen, Chengtie Wu
Summary: By utilizing microbial catalysis, uniform micro/nanostructures can be biologically synthesized on the surface of bioceramics, which exhibit excellent in vitro and in vivo bone-forming bioactivity. This bioinspired approach involves bacterial adhesion on biomaterials, bacterial-assisted production of CO32-, and nucleation and growth of CaCO3 nanocrystals on the surface of bioceramics.
ADVANCED MATERIALS
(2021)
Article
Engineering, Environmental
Yi Zheng, Wenping Ma, Zhibo Yang, Hongjian Zhang, Jingge Ma, Tian Li, Huicong Niu, Yanling Zhou, Qingqiang Yao, Jiang Chang, Yufang Zhu, Chengtie Wu
Summary: In this study, an inorganic hemostatic aerogel was developed, composed of ultralong hydroxyapatite nanowires and polyvinyl alcohol, showing excellent hemostatic activity and wound healing function. The aerogel exhibited super-hydrophilicity and super-hematophilicity, rapidly absorbing blood, accelerating hemostasis, and promoting skin wound healing.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Cuijun Deng, Quan Zhou, Meng Zhang, Tian Li, Haotian Chen, Chang Xu, Qishuai Feng, Xin Wang, Feng Yin, Yu Cheng, Chengtie Wu
Summary: The developed bioscaffold integrating antioxidant and mechanical properties shows great potential for osteochondral regeneration in osteoarthritis. It protects chondrocytes, promotes their proliferation and maturation, as well as accelerates the osteogenic differentiation of bone marrow mesenchymal stem cells.
Article
Materials Science, Multidisciplinary
Tian Li, Fei Han, Jianmin Xue, Hongshi Ma, Yongzhe Wang, Mingxiang Zhuang, Dudi Ren, Liang Wang, Jiang Chang, Chengtie Wu
Summary: The study introduces a universal biomineralization-assembly-sintering approach for the fabrication of well ordered microstructure meta-hydroxyapatite, inspired by high-performance natural composites. The material demonstrates remarkable mechanical performances matching that of human cortical bone, playing a significant role in stimulating bone defects regeneration in vivo.
APPLIED MATERIALS TODAY
(2021)
Article
Engineering, Biomedical
Zhibo Yang, Jianmin Xue, Tian Li, Dong Zhai, Xiaopeng Yu, Zhiguang Huan, Chengtie Wu
Summary: Bioceramics are commonly used in bone tissue repair and regeneration due to their desirable biocompatibility and bioactivity. However, their brittleness limits their clinical applications. Inspired by the properties of sponge spicules, researchers combined 2D bioceramics and 3D printing to construct flexible bioceramic-based scaffolds with spicule-like concentric layered biomimetic microstructures. These scaffolds exhibit enhanced flexibility and toughness compared to traditional scaffolds, allowing for various shape changes without fracture, and demonstrate improved in vitro and in vivo bone-forming bioactivity compared to conventional scaffolds.
Article
Engineering, Biomedical
Jianmin Xue, Hongshi Ma, Erhong Song, Fei Han, Tian Li, Meng Zhang, Yufang Zhu, Jianjun Liu, Chengtie Wu
Summary: Mineralized calcium phosphate/bamboo composite scaffolds with high strength and excellent transport performance are successfully prepared using biotemplated approach and biomimetic mineralization. The mineralized biomaterials have high mechanical strength and low modulus, and exhibit good liquid and cell transport capacity.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Tian Li, Quyang Liu, Haobo Qi, Wei Zhai
Summary: This research proposes a conceptual combination of bioinspired microstructure design and a programmable prestrain approach for 4D printing of nanoceramics. By replicating the bioinspired concentric cylinder structure and applying prestrain, the researchers successfully developed flexible nanoceramic composites with superior mechanical performance and anisotropic thermal management capability. Conductive nanoceramic composites with unique sensing capability were also prepared. This breakthrough in 4D printing of ceramics opens up possibilities for high-performance shape morphing materials in extreme conditions.
Article
Engineering, Manufacturing
Quyang Liu, Tian Li, Soo Wah Gan, Soon Yee Chang, Ching Chiuan Yen, Wei Zhai
Summary: In this study, hierarchical porous hydroxyapatite (hpHA) scaffolds with high porosity and superior mechanical properties were fabricated using 3D printing of emulsion inks. The scaffolds exhibited improved cell attachment and proliferation, indicating their potential for bone tissue engineering applications. The reported method of 3D printing emulsion inks is a promising strategy for the fabrication of highly porous scaffolds.
ADDITIVE MANUFACTURING
(2023)
Article
Engineering, Biomedical
Fei Han, Tian Li, Mengmeng Li, Bingjun Zhang, Yufeng Wang, Yufang Zhu, Chengtie Wu
Summary: This study utilized natural fish scale modified by calcium silicate nanoparticles as a new biomaterial to overcome the challenge of tendon-bone healing. The fish scale-based scaffold demonstrated excellent tensile strength and bioactivity, making it a promising candidate for clinical tendon repair. The research also showed that the biomaterial played a key role in tendon-bone interface regeneration and biomechanical function.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Tian Li, Haobo Qi, Xinyu Dong, Guanjin Li, Wei Zhai
Summary: This work fabricates a strong and tough conductive hierarchical organo-hydrogel with outstanding mechanical performances and sensing capabilities, unlocking new possibilities for applications in human-machine interfaces and sports training.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Tian Li, Quyang Liu, Jing Cao, Soo Wah Gan, Xinyu Dong, Ching Chiuan Yen, Chengtie Wu, Wei Zhai
Summary: We present a simple technique to produce nanosheets from layered crystals by selectively exfoliating their interlayer metal atoms using the metal-chelation reaction. As a proof of concept, we successfully produced bioceramic nanosheets (BCene) by extracting Ca layers from Akermanite (AKT). The 3D-printed BCene scaffolds exhibited superior mechanical strength and in vitro bioactivity compared to the scaffolds made from AKT nanopowders. Our findings demonstrate the outstanding potential of BCene nanosheets in tissue engineering, and the selective demetallization technique for nanosheet production could be applied to other inorganic layered crystals to optimize their performance.
Article
Materials Science, Biomaterials
Jinzhou Huang, Dong Zhai, Jianmin Xue, Tian Li, Dudi Ren, Chengtie Wu
Summary: By utilizing a directional assembly-sintering approach, laminated MXene/calcium silicate-based bioceramics with excellent mechanical and biological properties for bone tissue engineering were successfully fabricated.
REGENERATIVE BIOMATERIALS
(2022)
