Asymmetric Construction of Pyrrolidines Bearing a Trifluoromethylated Quaternary Stereogenic Center via CuI -Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with β-CF3 -β,β-Disubstituted Nitroalkenes

Diastereo- and Enantioselective Copper(I)-Catalyzed Intermolecular [3+2] Cycloaddition of Azomethine Ylides with β-Trifluoromethyl β,β-Disubstituted Enones

(2016) Zhan-Ming Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric catalytic formation of quaternary carbons by iminium ion trapping of radicals

(2016) John J. Murphy et al.   NATURE

A CuII-N,P Oxazolinylferrocene Ligand Complex for the Asymmetric [3+2] 1,3-Dipolar Cycloaddition of Azomethine Ylide with Malonates

(2015) Li Dai et al.   ChemCatChem

Catalytic highly enantioselective transfer hydrogenation of β-trifluoromethyl nitroalkenes. An easy and general entry to optically active β-trifluoromethyl amines

(2015) Emilie Martinelli et al.   CHEMICAL COMMUNICATIONS

Chiral N,O-Ligand/[Cu(OAc)2]-Catalyzed Asymmetric Construction of 4-Aminopyrrolidine Derivatives by 1,3-Dipolar Cycloaddition of Azomethine Ylides with α-Phthalimidoacrylates

(2015) Zheng Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Organocatalytic Reduction of β-Trifluoromethyl Nitroalkenes: An Efficient Strategy for the Synthesis of Chiral β-Trifluoromethyl Amines

(2015) Elisabetta Massolo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ligand-Controlled Diastereoselective 1,3-Dipolar Cycloadditions of Azomethine Ylides with Methacrylonitrile

(2015) Mary C. Walton et al.   ORGANIC LETTERS

Highly Enantioselective Cascade Reaction Catalyzed by Squaramides: the Synthesis of CF3-Containing Chromanes

(2015) Yuanyuan Zhu et al.   ORGANIC LETTERS

The design, synthesis and application of imidazolium-tagged ferrocenyl oxazoline phosphine ligands for the asymmetric 1,3-dipolar cycloaddition of azomethine ylides with nitroalkenes: ion effect for enhancing the reactivity, stereoselectivity and recyclability

(2015) Li Dai et al.   TETRAHEDRON-ASYMMETRY

Chiral Fullerenes from Asymmetric Catalysis

(2014) Enrique E. Maroto et al.   ACCOUNTS OF CHEMICAL RESEARCH

Recent advances in the catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides

(2014) Javier Adrio et al.   CHEMICAL COMMUNICATIONS

Recent advances in the trifluoromethylation methodology and new CF3-containing drugs

(2014) Wei Zhu et al.   JOURNAL OF FLUORINE CHEMISTRY

Catalytic enantioselective synthesis of quaternary carbon stereocentres

(2014) Kyle W. Quasdorf et al.   NATURE

Highly Enantioselective Organocatalyzed Vinylogous Michael-Type Reaction for the Construction of Trifluoromethylated All-Carbon Quaternary Stereocenters

(2014) Qiao Chen et al.   ORGANIC LETTERS

exo-Selective construction of spiro-[butyrolactone-pyrrolidine] via 1,3-dipolar cycloaddition of azomethine ylides with α-methylene-γ-butyrolactone catalyzed by Cu(i)/DTBM-BIPHEP

(2013) Qing-Hua Li et al.   CHEMICAL COMMUNICATIONS

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Catalytic Asymmetric Construction of Quaternary α-Amino Acid Containing Pyrrolidines through 1,3-Dipolar Cycloaddition of Azomethine Ylides to α-Aminoacrylates

(2013) Zheng Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Enantioselective Construction of Trifluoromethylated All-Carbon Quaternary Stereocenters via Nickel-Catalyzed Friedel–Crafts Alkylation Reaction

(2013) Jian-Rong Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones

(2012) Renato Dalpozzo et al.   CHEMICAL SOCIETY REVIEWS

Catalytic Asymmetric Construction of Spirocycles Containing Pyrrolidine Motifs and Spiro Quaternary Stereogenic Centers via 1,3-Dipolar Cycloaddition of Azomethine Ylides with 2-Alkylidene-Cycloketones

(2011) Tang-Lin Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Complete 2,5-Diastereocontrol in the Organocatalytic Enantioselective [3+2] Cycloaddition of Enals with Azomethine Ylides Derived from α-Iminocyanoacetates: Asymmetric Synthesis of Pyrrolidines with Four Stereocentres

(2011) Silvia Reboredo et al.   ADVANCED SYNTHESIS & CATALYSIS

Dynamic One-Pot Three-Component Catalytic Asymmetric Transformation by Combination of Hydrogen-Bond-Donating and Amine Catalysts

(2011) Shuangzheng Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Simple Recipe for Sophisticated Cocktails: Organocatalytic One-Pot Reactions-Concept, Nomenclature, and Future Perspectives

(2011) Łukasz Albrecht et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly efficient construction of spirocyclic chromanone–pyrrolidines via Cu(i)/TF–BiphamPhos-catalyzed asymmetric 1,3-dipolar cycloaddition

(2011) Tang-Lin Liu et al.   CHEMICAL COMMUNICATIONS

Novel dipolarophiles and dipoles in the metal-catalyzed enantioselective 1,3-dipolar cycloaddition of azomethine ylides

(2011) Javier Adrio et al.   CHEMICAL COMMUNICATIONS

Enantioselective synthesis of all-carbon quaternary stereogenic centers in acyclic systems

(2011) Jaya Prakash Das et al.   CHEMICAL COMMUNICATIONS

Morita–Baylis–Hillman adducts as effective dipolarophiles in Copper(i)-catalyzed 1,3-dipolar cycloaddition with azomethine ylides: asymmetric construction of pyrrolidine derivatives containing quaternary stereogenic center

(2011) Huai-Long Teng et al.   CHEMICAL COMMUNICATIONS

A Diels–Alder approach to the enantioselective construction of fluoromethylated stereogenic carbon centers

(2011) Kazutaka Shibatomi et al.   CHEMICAL COMMUNICATIONS

Asymmetric Organocatalytic Cyclization and Cycloaddition Reactions

(2011) Albert Moyano et al.   CHEMICAL REVIEWS

Natural products and Pharma 2011: Strategic changes spur new opportunities

(2011) Guy T. Carter   NATURAL PRODUCT REPORTS

TiCl4-Promoted Mukaiyama Aldol Reaction of Fluorinated Silyl Enolates for the Construction of a Quaternary Carbon Center

(2011) Yong Guo et al.   SYNLETT

Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates

(2010) Jing Nie et al.   CHEMICAL REVIEWS

Catalytic Enantioselective Construction of β-Quaternary Carbons via a Conjugate Addition of Cyanide to β,β-Disubstituted α,β-Unsaturated Carbonyl Compounds

(2010) Yuta Tanaka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

What Controls the Reactivity of 1,3-Dipolar Cycloadditions?

(2009) Bernd Engels et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Convenient Synthesis ofN-Terminal Tfm-Dipeptides from Unprotected Enantiopure α-Tfm-Proline and α-Tfm-Alanine

(2009) Grégory Chaume et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Copper-Catalyzed 1,3-Dipolar Cycloadditions

(2008) Levi M. Stanley et al.   CHEMICAL REVIEWS

Update 1 of: Asymmetric Fluorination, Trifluoromethylation, and Perfluoroalkylation Reactions

(2008) Jun-An Ma et al.   CHEMICAL REVIEWS

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments

(2008) Kenneth L. Kirk   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS