Tomatidine, a natural steroidal alkaloid shows antiviral activity towards chikungunya virus in vitro

Tropism of the Chikungunya Virus

(2019) Giulia Matusali et al.   Viruses-Basel

Tomatidine Is a Lead Antibiotic Molecule That Targets Staphylococcus aureus ATP Synthase Subunit C

(2018) Maxime Lamontagne Boulet et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antiviral treatment efficiently inhibits chikungunya virus infection in the joints of mice during the acute but not during the chronic phase of the infection

(2018) Rana Abdelnabi et al.   ANTIVIRAL RESEARCH

Deciphering the potential of baicalin as an antiviral agent for Chikungunya virus infection

(2018) Adrian Oo et al.   ANTIVIRAL RESEARCH

Design, synthesis and evaluation against Chikungunya virus of novel small-molecule antiviral agents

(2018) Roberta Tardugno et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular and Clinical Characterization of Chikungunya Virus Infections in Southeast Mexico

(2018) Kame Galán-Huerta et al.   Viruses-Basel

Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis

(2018) Despina Contopoulos-Ioannidis et al.   PLoS Neglected Tropical Diseases

Tomatidine and analog FC04–100 possess bactericidal activities against Listeria, Bacillus and Staphylococcus spp

(2018) Isabelle Guay et al.   BMC Pharmacology & Toxicology

Tomatidine, a novel antiviral compound towards dengue virus

(2018) Mayra Diosa-Toro et al.   ANTIVIRAL RESEARCH

A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses

(2018) Jesse Hwang et al.   ANTIVIRAL RESEARCH

Cellular and Molecular Immune Response to Chikungunya Virus Infection

(2018) Ithallo S. B. Tanabe et al.   Frontiers in Cellular and Infection Microbiology

Tomatidine Attenuates Airway Hyperresponsiveness and Inflammation by Suppressing Th2 Cytokines in a Mouse Model of Asthma

(2017) Chieh-Ying Kuo et al.   MEDIATORS OF INFLAMMATION

Discovery of a novel antiviral agent targeting the nonstructural protein 4 (nsP4) of chikungunya virus

(2017) Yuji Wada et al.   VIROLOGY

Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses

(2016) Finny S. Varghese et al.   ANTIVIRAL RESEARCH

Suramin treatment reduces chikungunya pathogenesis in mice

(2016) Szu-Cheng Kuo et al.   ANTIVIRAL RESEARCH

Antiviral activities of niclosamide and nitazoxanide against chikungunya virus entry and transmission

(2016) Yu-Ming Wang et al.   ANTIVIRAL RESEARCH

Inhibition of chikungunya virus replication by hesperetin and naringenin

(2016) Azin Ahmadi et al.   RSC Advances

Suramin inhibits chikungunya virus replication through multiple mechanisms

(2015) Irina C. Albulescu et al.   ANTIVIRAL RESEARCH

Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy

(2015) Scott M. Ebert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chikungunya virus fusion properties elucidated by single-particle and bulk approaches

(2015) Mareike K. S. van Duijl-Richter et al.   JOURNAL OF GENERAL VIROLOGY

Chikungunya Virus and the Global Spread of a Mosquito-Borne Disease

(2015) Scott C. Weaver et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiviral activity of silymarin against chikungunya virus

(2015) Rafidah Lani et al.   Scientific Reports

Unraveling the structure–activity relationship of tomatidine, a steroid alkaloid with unique antibiotic properties against persistent forms of Staphylococcus aureus

(2014) Félix Chagnon et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral

(2014) Leen Delang et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Systems-based Discovery of Tomatidine as a Natural Small Molecule Inhibitor of Skeletal Muscle Atrophy

(2014) Michael C. Dyle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chikungunya fever: Epidemiology, clinical syndrome, pathogenesis and therapy

(2013) Simon-Djamel Thiberville et al.   ANTIVIRAL RESEARCH

Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression

(2013) Kun-Huang Yan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Identification of Novel Compounds Inhibiting Chikungunya Virus-Induced Cell Death by High Throughput Screening of a Kinase Inhibitor Library

(2013) Deu John M. Cruz et al.   PLoS Neglected Tropical Diseases

Tomatidine Inhibits Replication of Staphylococcus aureus Small-Colony Variants in Cystic Fibrosis Airway Epithelial Cells

(2011) Gabriel Mitchell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tomatidine, a Tomato Sapogenol, Ameliorates Hyperlipidemia and Atherosclerosis in ApoE-Deficient Mice by Inhibiting Acyl-CoA:cholesterol Acyl-transferase (ACAT)

(2011) Yukio Fujiwara et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Biology and pathogenesis of chikungunya virus

(2010) Olivier Schwartz et al.   NATURE REVIEWS MICROBIOLOGY

Tomatidine inhibits iNOS and COX-2 through suppression of NF-κB and JNK pathways in LPS-stimulated mouse macrophages

(2008) Feng-Lan Chiu et al.   FEBS LETTERS