Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent

Ascorbic Acid 2-Glucoside Pretreatment Protects Cells from Ionizing Radiation, UVC, and Short Wavelength of UVB

(2020) Junko Maeda et al.   Genes

Combination Therapy with Vitamin C Could Eradicate Cancer Stem Cells

(2020) Noothan Jyothi Satheesh et al.   Biomolecules

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vitamin C as a Modulator of the Response to Cancer Therapy

(2019) Wiktoria Blaszczak et al.   MOLECULES

Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities

(2019) Judit M. Perez Ortiz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Comparison of oxidant/antioxidant balance in COPD and non-COPD smokers

(2019) Yusuf Aydemir et al.   HEART & LUNG

Maternal vitamin C regulates reprogramming of DNA methylation and germline development

(2019) Stephanie P. DiTroia et al.   NATURE

Relationship between smoking and total antioxidant status, total oxidant status, oxidative stress index, vit C, vit E

(2018) Merve Karademirci et al.   Clinical Respiratory Journal

Cisplatin-induced gastrointestinal toxicity: An update on possible mechanisms and on available gastroprotective strategies

(2018) Faaiza Shahid et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The role of vitamin C in the gene expression of oxidative stress markers in fibroblasts from burn patients

(2018) Jessica Bonucci et al.   Acta Cirurgica Brasileira

Protective effect of pre- and post-vitamin C treatments on UVB-irradiation-induced skin damage

(2018) Saki Kawashima et al.   Scientific Reports

The Association Between Ascorbate and the Hypoxia-Inducible Factors in Human Renal Cell Carcinoma Requires a Functional Von Hippel-Lindau Protein

(2018) Christina Wohlrab et al.   Frontiers in Oncology

Antioxidants Taken Orally prior to Diagnostic Radiation Exposure Can Prevent DNA Injury

(2017) Nivethan Velauthapillai et al.   JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY

The role of vitamin C in epigenetic regulation

(2017) Jolanta Guz et al.   Postepy Higieny I Medycyny Doswiadczalnej

Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs)

(2017) Ernestina Marianna De Francesco et al.   Oncotarget

Ascorbate induces apoptosis in melanoma cells by suppressing Clusterin expression

(2017) Sushmita Mustafi et al.   Scientific Reports

Vitamin C in synergism with cisplatin induces cell death in cervical cancer cells through altered redox cycling and p53 upregulation

(2016) Ankita Leekha et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Vitamin C: the known and the unknown and Goldilocks

(2016) SJ Padayatty et al.   ORAL DISEASES

The emerging insights into catalytic or non-catalytic roles of TET proteins in tumors and neural development

(2016) Hao Lian et al.   Oncotarget

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy

(2016) Claire M. Doskey et al.   Redox Biology

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

A fluorescent bimolecular complementation screen reveals MAF1, RNF7 and SETD3 as PCNA-associated proteins in human cells

(2015) Simon E Cooper et al.   CELL CYCLE

Old Things New View: Ascorbic Acid Protects the Brain in Neurodegenerative Disorders

(2015) Adriana Covarrubias-Pinto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Relief of delayed oxidative stress by ascorbic acid can suppress radiation-induced cellular senescence in mammalian fibroblast cells

(2015) Shinko Kobashigawa et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Ionizing Radiation-Induced Cell Death Is Partly Caused by Increase of Mitochondrial Reactive Oxygen Species in Normal Human Fibroblast Cells

(2015) Shinko Kobashigawa et al.   RADIATION RESEARCH

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

(2015) J. Yun et al.   SCIENCE

High 15-F2t-Isoprostane Levels in Patients with a Previous History of Nonmelanoma Skin Cancer: The Effects of Supplementary Antioxidant Therapy

(2015) Betânia de Jesus e Silva de Almendra Freitas et al.   Biomed Research International

Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress

(2015) Megumi Uetaki et al.   Scientific Reports

Vitamin C and survival among women with breast cancer: A Meta-analysis

(2014) Holly R. Harris et al.   EUROPEAN JOURNAL OF CANCER

The protective effects of vitamin C on the DNA damage, antioxidant defenses and aorta histopathology in chronic hyperhomocysteinemia induced rats

(2014) Murat Boyacioglu et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

TET1 Exerts Its Tumor Suppressor Function by Interacting with p53-EZH2 Pathway in Gastric Cancer

(2014) Hua-Lin Fu et al.   Journal of Biomedical Nanotechnology

High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy

(2014) Y. Ma et al.   Science Translational Medicine

High-dose of vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brain of 5XFAD mice

(2014) S-Y Kook et al.   Cell Death & Disease

Effects of a nutrient mixture on immunohistochemical localization of cancer markers in human cervical cancer HeLa cell tumor xenografts in female nude mice

(2014) M.W. ROOMI et al.   Experimental and Therapeutic Medicine

Suppression of TET1-Dependent DNA Demethylation Is Essential for KRAS-Mediated Transformation

(2014) Bo-Kuan Wu et al.   Cell Reports

DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia

(2014) Raajit Rampal et al.   Cell Reports

Mitochondrial superoxide mediates labile iron level: evidence from Mn-SOD-transgenic mice and heterozygous knockout mice and isolated rat liver mitochondria

(2013) Wissam H. Ibrahim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort

(2013) Eric J. Duell et al.   Genes and Nutrition

Ascorbic Acid Enhances Tet-Mediated 5-Methylcytosine Oxidation and Promotes DNA Demethylation in Mammals

(2013) Ruichuan Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ROS and Brain Diseases: The Good, the Bad, and the Ugly

(2013) Aurel Popa-Wagner et al.   Oxidative Medicine and Cellular Longevity

5-hydroxymethylcytosine and its potential roles in development and cancer

(2013) Gerd P Pfeifer et al.   Epigenetics & Chromatin

The Discovery of Vitamin C

(2012) Kenneth J. Carpenter   ANNALS OF NUTRITION AND METABOLISM

Ascorbic acid: Chemistry, biology and the treatment of cancer

(2012) Juan Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Ascorbic acid efficiently enhances neuronal synthesis of norepinephrine from dopamine

(2012) James M. May et al.   BRAIN RESEARCH BULLETIN

Enhanced antitumor activity of vitamin C via p53 in Cancer cells

(2012) Jinsun Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibitors of hydroperoxide metabolism enhance ascorbate-induced cytotoxicity

(2012) K. E. Olney et al.   FREE RADICAL RESEARCH

The Role of Oxidative Stress in Smoking-Related Diseases

(2012) Ian M. Fearon et al.   MINI-REVIEWS IN ORGANIC CHEMISTRY

DNA Repair and Cancer Therapy: Targeting APE1/Ref-1 Using Dietary Agents

(2012) Julian J. Raffoul et al.   Journal of Oncology

Pharmacological ascorbate induces cytotoxicity in prostate cancer cells through ATP depletion and induction of autophagy

(2011) Ping Chen et al.   ANTI-CANCER DRUGS

5-Hydroxymethylcytosine Is Strongly Depleted in Human Cancers but Its Levels Do Not Correlate with IDH1 Mutations

(2011) S.-G. Jin et al.   CANCER RESEARCH

Ascorbic Acid: An Old Player with a Broad Impact on Body Physiology Including Oxidative Stress Suppression and Immunomodulation: A Review

(2011) M. Pohanka et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Expression of XRCC5 in peripheral blood lymphocytes is upregulated in subjects from a heavily polluted region in the Czech Republic

(2011) Pavel Rossner et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Antioxidant enzymes and cancer

(2010) Md. Asaduzzaman Khan et al.   Chinese Journal of Cancer Research

Mechanisms of Ascorbate-Induced Cytotoxicity in Pancreatic Cancer

(2010) J. Du et al.   CLINICAL CANCER RESEARCH

Vitamin C Transporter Gene Polymorphisms, Dietary Vitamin C and Serum Ascorbic Acid

(2010) Leah E. Cahill et al.   Journal of Nutrigenetics and Nutrigenomics

Mutagenicity of oxidized DNA precursors in living cells: Roles of nucleotide pool sanitization and DNA repair enzymes, and translesion synthesis DNA polymerases

(2010) Hiroyuki Kamiya   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Can vitamin C induce nucleotide excision repair? Support from in vitro evidence

(2009) Ruth J. Bevan et al.   BRITISH JOURNAL OF NUTRITION

Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects

(2009) Julien Verrax et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2

(2009) Fiona E. Harrison et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sailors' scurvy before and after James Lind - a reassessment

(2009) Jeremy Hugh Baron   NUTRITION REVIEWS

Gene expression profiling reveals new protective roles for vitamin C in human skin cells

(2008) T DUARTE et al.   FREE RADICAL BIOLOGY AND MEDICINE

Body iron metabolism and pathophysiology of iron overload

(2008) Yutaka Kohgo et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Vitamins C and E and Beta Carotene Supplementation and Cancer Risk: A Randomized Controlled Trial

(2008) J. Lin et al.   JNCI-Journal of the National Cancer Institute

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

(2008) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA