Sodium–glucose cotransporters: Functional properties and pharmaceutical potential

Sotagliflozin, the first dual SGLT inhibitor: current outlook and perspectives

(2019) Chiara Maria Assunta Cefalo et al.   Cardiovascular Diabetology

Elevated glucose concentration in culture media decreases membrane trafficking of SGLT2 in LLC-PK1 cells via a cAMP/PKA dependent pathway

(2019) Siddharth Sunilkumar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

(2019) Vlado Perkovic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Renal protective effect of SGLT2 inhibitor dapagliflozin alone and in combination with irbesartan in a rat model of diabetic nephropathy

(2018) Ali F. Abdel-Wahab et al.   BIOMEDICINE & PHARMACOTHERAPY

Dual inhibition of sodium–glucose linked cotransporters 1 and 2 exacerbates cardiac dysfunction following experimental myocardial infarction

(2018) Kim A. Connelly et al.   Cardiovascular Diabetology

The Anticipated Renoprotective Effects of Sodium-glucose Cotransporter 2 Inhibitors

(2018) Marie Ito et al.   INTERNAL MEDICINE

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

(2018) Stephen D. Wiviott et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Na+-D-glucose cotransporters SGLT1 and SGLT2 are targets for the treatment of diabetes and cancer

(2017) Hermann Koepsell   PHARMACOLOGY & THERAPEUTICS

Intestinal SGLT1 in metabolic health and disease

(2016) Anders Lehmann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Expression of JAK3 Sensitive Na+ Coupled Glucose Carrier SGLT1 in Activated Cytotoxic T Lymphocytes

(2016) Shefalee K. Bhavsar et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Sodium glucose cotransporter SGLT1 as a therapeutic target in diabetes mellitus

(2016) Panai Song et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The SGLT2 inhibitor empagliflozin improves insulin sensitivity in db/db mice both as monotherapy and in combination with linagliptin

(2016) Matthias Kern et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes

(2016) Christoph Wanner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diabetes Alters the Expression and Translocation of the Insulin-Sensitive Glucose Transporters 4 and 8 in the Atria

(2016) Zahra Maria et al.   PLoS One

Ipragliflozin Improves Hepatic Steatosis in Obese Mice and Liver Dysfunction in Type 2 Diabetic Patients Irrespective of Body Weight Reduction

(2016) Chikara Komiya et al.   PLoS One

Effect of Sodium-Glucose Co-Transporter 2 Inhibitor, Dapagliflozin, on Renal Renin-Angiotensin System in an Animal Model of Type 2 Diabetes

(2016) Seok Joon Shin et al.   PLoS One

Selective sodium-dependent glucose transporter 1 inhibitors block glucose absorption and impair glucose-dependent insulinotropic peptide release

(2015) Robert L. Dobbins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Mechanisms and Therapeutic Potential of SGLT2 Inhibitors in Diabetes Mellitus

(2015) Volker Vallon   Annual Review of Medicine

Sodium-glucose cotransport

(2015) Søren Brandt Poulsen et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion

(2015) Caroline Bonner et al.   NATURE MEDICINE

A comprehensive review of the pharmacodynamics of the SGLT2 inhibitor empagliflozin in animals and humans

(2015) Martin C. Michel et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus

(2015) Shirong Qiang et al.   Diabetology & Metabolic Syndrome

Expression of SGLT1 in Human Hearts and Impairment of Cardiac Glucose Uptake by Phlorizin during Ischemia-Reperfusion Injury in Mice

(2015) Yusuke Kashiwagi et al.   PLoS One

SPAK-Sensitive Regulation of Glucose Transporter SGLT1

(2014) Bernat Elvira et al.   JOURNAL OF MEMBRANE BIOLOGY

GLUT1 deficiency in cardiomyocytes does not accelerate the transition from compensated hypertrophy to heart failure

(2014) Renata O. Pereira et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

GLUT3 gene expression is critical for embryonic growth, brain development and survival

(2014) Mary O. Carayannopoulos et al.   MOLECULAR GENETICS AND METABOLISM

Localizations of Na+-d-glucose cotransporters SGLT1 and SGLT2 in human kidney and of SGLT1 in human small intestine, liver, lung, and heart

(2014) Ivana Vrhovac et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The Role of SGLT1 and GLUT2 in Intestinal Glucose Transport and Sensing

(2014) Pia V. Röder et al.   PLoS One

Long-Term Treatment with the Sodium Glucose Cotransporter 2 Inhibitor, Dapagliflozin, Ameliorates Glucose Homeostasis and Diabetic Nephropathy in db/db Mice

(2014) Naoto Terami et al.   PLoS One

Transgenic Knockdown of Cardiac Sodium/Glucose Cotransporter 1 (SGLT1) Attenuates PRKAG2 Cardiomyopathy, Whereas Transgenic Overexpression of Cardiac SGLT1 Causes Pathologic Hypertrophy and Dysfunction in Mice

(2014) Mohun Ramratnam et al.   Journal of the American Heart Association

Novel Hypothesis to Explain Why SGLT2 Inhibitors Inhibit Only 30-50% of Filtered Glucose Load in Humans

(2013) M. A. Abdul-Ghani et al.   DIABETES

Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice

(2013) Atsuo Tahara et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of SGLT2 Inhibition in Human Kidney Proximal Tubular Cells—Renoprotection in Diabetic Nephropathy?

(2013) Usha Panchapakesan et al.   PLoS One

Inducible Overexpression of GLUT1 Prevents Mitochondrial Dysfunction and Attenuates Structural Remodeling in Pressure Overload but Does Not Prevent Left Ventricular Dysfunction

(2013) Renata O. Pereira et al.   Journal of the American Heart Association

SGLT inhibitors in management of diabetes

(2013) Abd A Tahrani et al.   Lancet Diabetes & Endocrinology

Regulation of the human Na+-dependent glucose cotransporter hSGLT2

(2012) Chiara Ghezzi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Expression of Na+-d-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences

(2012) Ivan Sabolić et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Improved glycemic control in mice lacking Sglt1 and Sglt2

(2012) David R. Powell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

LX4211, a Dual SGLT1/SGLT2 Inhibitor, Improved Glycemic Control in Patients With Type 2 Diabetes in a Randomized, Placebo-Controlled Trial

(2012) B Zambrowicz et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Why Do SGLT2 Inhibitors Inhibit Only 30-50% of Renal Glucose Reabsorption in Humans?

(2012) J. Liu et al.   DIABETES

Empagliflozin, a novel potent and selective SGLT-2 inhibitor, improves glycaemic control alone and in combination with insulin in streptozotocin-induced diabetic rats, a model of type 1 diabetes mellitus

(2012) G. Luippold et al.   DIABETES OBESITY & METABOLISM

Autocrine modulation of glucose transporter SGLT2 by IL-6 and TNF-α in LLC-PK1 cells

(2012) M. I. Maldonado-Cervantes et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Renal Function in Diabetic Disease Models: The Tubular System in the Pathophysiology of the Diabetic Kidney

(2011) Volker Vallon et al.   Annual Review of Physiology

Na+-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion

(2011) V. Gorboulev et al.   DIABETES

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia

(2011) R. A. DeFronzo et al.   DIABETES OBESITY & METABOLISM

Biology of Human Sodium Glucose Transporters

(2011) Ernest M. Wright et al.   PHYSIOLOGICAL REVIEWS

Glucose transport by human renal Na+/d-glucose cotransporters SGLT1 and SGLT2

(2010) Charles S. Hummel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Sodium–glucose transport: role in diabetes mellitus and potential clinical implications

(2010) Volker Vallon et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy

(2010) Sanjay K. Banerjee et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

SGLT2 Mediates Glucose Reabsorption in the Early Proximal Tubule

(2010) V. Vallon et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulation of Na+-coupled glucose carrier SGLT1 by AMP-activated protein kinase

(2010) Mentor Sopjani et al.   MOLECULAR MEMBRANE BIOLOGY

Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members

(2010) Jian Chen et al.   Diabetes Therapy

Facilitative glucose transporter 9, a unique hexose and urate transporter

(2009) Manuel Doblado et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

GLUT2 mutations, translocation, and receptor function in diet sugar managing

(2009) Armelle Leturque et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Activation of sodium-glucose cotransporter 1 ameliorates hyperglycemia by mediating incretin secretion in mice

(2009) Ryuichi Moriya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Evaluation of expression and function of the H+/myo-inositol transporter HMIT

(2009) Elena Di Daniel et al.   BMC CELL BIOLOGY

SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states

(2009) S. K. Banerjee et al.   CARDIOVASCULAR RESEARCH

Familial Renal Glucosuria and SGLT2: From a Mendelian Trait to a Therapeutic Target

(2009) R. Santer et al.   Clinical Journal of the American Society of Nephrology

Protein kinase-A affects sorting and conformation of the sodium-dependent glucose co-transporter SGLT1

(2009) Supriya Subramanian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Na+-Glucose Cotransporter SGLT1 Protein in Salivary Glands: Potential Involvement in the Diabetes-Induced Decrease in Salivary Flow

(2009) R. Sabino-Silva et al.   JOURNAL OF MEMBRANE BIOLOGY

Androgen Suppresses Corticotropin-Induced Increase in Plasma Cortisol Level but Enhances The Increase in Plasma Aldosterone Level in Goats

(2009) Masato AOYAMA et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Mutations in Glucose Transporter 9 Gene SLC2A9 Cause Renal Hypouricemia

(2008) Hirotaka Matsuo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Revised immunolocalization of the Na+-d-glucose cotransporter SGLT1 in rat organs with an improved antibody

(2008) Daniela Balen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

GLUT7: a new intestinal facilitated hexose transporter

(2008) Chris Cheeseman   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sugar Absorption in the Intestine: The Role of GLUT2

(2008) George L. Kellett et al.   Annual Review of Nutrition

Regulation of sarcolemmal glucose and fatty acid transporters in cardiac disease

(2008) R. W. Schwenk et al.   CARDIOVASCULAR RESEARCH

Enhanced expressions of sodium–glucose cotransporters in the kidneys of diabetic Zucker rats

(2008) Niloofar M. Tabatabai et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Transmembrane Segment 6 of the Glut1 Glucose Transporter Is an Outer Helix and Contains Amino Acid Side Chains Essential for Transport Activity

(2008) Mike Mueckler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma Urate Level Is Directly Regulated by a Voltage-driven Urate Efflux Transporter URATv1 (SLC2A9) in Humans

(2008) Naohiko Anzai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY