Article
Multidisciplinary Sciences
Tiffany Tate, Tina Xiang, Sarah E. Wobker, Mi Zhou, Xiao Chen, Hyunwoo Kim, Ekatherina Batourina, Chyuan-Sheng Lin, William Y. Kim, Chao Lu, James M. Mckiernan, Cathy Lee Mendelsohn
Summary: The differential expression of PPARg in bladder cancer subtypes plays a crucial role in tumor formation and progression. The activation of Pparg in basal bladder cells can prevent tumor formation but injury-induced differentiation of these cells into luminal cells can lead to tumor development. Understanding the molecular mechanisms behind subtype transition provides important insights for the diagnosis and treatment of bladder cancer.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Lin Yang, Shuangling Wu, Chunhui Ma, Shuhui Song, Feng Jin, Yamei Niu, Wei-Min Tong
Summary: This study comprehensively explores the characteristics of m(6)A regulators in breast cancer and their correlation with prognosis, highlighting the unique features of the basal-like subtype compared to other subtypes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Tejaswi Iyyanki, Baozhen Zhang, Qixuan Wang, Ye Hou, Qiushi Jin, Jie Xu, Hongbo Yang, Tingting Liu, Xiaotao Wang, Fan Song, Yu Luan, Hironobu Yamashita, Ruby Chien, Huijue Lyu, Lijun Zhang, Lu Wang, Joshua Warrick, Jay D. Raman, Joshua J. Meeks, David J. DeGraff, Feng Yue
Summary: The study identified unique epigenomic signatures and 3D genome structures in luminal and basal urinary bladder cancers, and suggested a novel association between the circadian transcription factor NPAS2 and a clinical subtype of bladder cancer.
Article
Biochemistry & Molecular Biology
Aaron A. Mehus, Nicholas Bergum, Peter Knutson, Swojani Shrestha, Matthew Kalonick, Xudong Zhou, Scott H. Garrett, Donald A. Sens, Mary Ann Sens, Seema Somji
Summary: The bladder is a target organ for inorganic arsenic. Chronic arsenic exposure can convert non-invasive papillary bladder cancer to an invasive form with basal characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kamil Luczykowski, Natalia Warmuzinska, Sylwia Operacz, Iga Stryjak, Joanna Bogusiewicz, Julia Jacyna, Renata Wawrzyniak, Wiktoria Struck-Lewicka, Michal J. Markuszewski, Barbara Bojko
Summary: This study introduces untargeted metabolomic profiling of biological fluids as a tool for the discovery of bladder cancer biomarkers. The analysis of metabolites contributing to differences could support a better understanding of bladder cancer development mechanisms.
Article
Biochemistry & Molecular Biology
Zi Wang, Bircan Coban, Chen-Yi Liao, Yao-Jun Chen, Qiuyu Liu, Erik H. J. Danen
Summary: GRHL2 has different roles in different breast cancer subtypes, promoting cancer growth in some subtypes and suppressing cancer progression in others. Its expression is increased in all subtypes of breast cancer and inversely correlated with overall survival in basal-like breast cancer patients. GRHL2 regulates cell-cell junction, epithelial migration, and proliferation in both luminal and basal A breast cancer subtypes, but has distinct effects on cell cycle arrest and migration in these subtypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Ines Simeone, Michele Ceccarelli
Summary: We developed a novel data-driven approach to identify shared oncogenic expression signatures among tumors and used it to classify patients and predict prognosis. We also discovered a mitochondrial sub-group of Luminal breast cancer patients with specific biological features and genetic regulation. These findings provide genomics evidence for personalized breast cancer patient treatments.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Irene J. Beijert, Anouk E. Hentschel, Johannes Brundl, Eva M. Comperat, Karin Plass, Oscar Rodriguez, Jose D. Subiela Henriquez, Virginia Henraquez, Enrique de la Pena, Isabel Alemany, Diana Turturica, Francesca Pisano, Francesco Soria, Otakar Capoun, Lenka Bauerova, Michael Pesl, H. Maxim Bruins, Willemien Runneboom, Sonja Herdegen, Johannes Breyer, Antonin Brisuda, Ana Calatrava, Jose Rubio-Briones, Maximilian Seles, Sebastian Mannweiler, Judith Bosschieter, Venkata R. M. Kusuma, David Ashabere, Nicolai Huebner, Juliette Cotte, Laura S. Mertens, Francesco Claps, Alexandra Masson-Lecomte, Fredrik Liedberg, Daniel Cohen, Luca Lunelli, Olivier Cussenot, Soha El Sheikh, Dimitrios Volanis, Jean-Francois Cote, Morgan Roupret, Andrea Haitel, Shahrokh F. Shariat, A. Hugh Mostafid, Jakko A. Nieuwenhuijzen, Richard Zigeuner, Jose L. Dominguez-Escrig, Jaromir Hacek, Alexandre R. Zlotta, Maximilian Zigeuner, Matthias Evert, Christina A. Hulsbergen-van de Kaa, Antoine G. van der Heijden, Lambertus A. L. M. Kiemeney, Viktor Soukup, Luca Molinaro, Paolo Gontero, Carlos Llorente, Ferran Algaba, Joan Palou, James N'Dow, Maria J. Ribal, Theo H. van der Kwast, Marko Babjuk, Richard J. Sylvester, Bas W. G. van Rhijn
Summary: This study evaluated the prognostic value of categorizing Ta G3 compared to Ta G2 and T1 G3 bladder cancer. The results showed that the time to progression for Ta G3 cancer is between that of Ta G2 and T1 G3 tumors, while patients with Ta G3 NMIBC with concomitant carcinoma in situ (CIS) have a worse prognosis similar to that of T1 G3 with CIS. These findings support the recent changes in the European Association of Urology guidelines for more refined risk stratification of Ta G3 tumors, as many Ta G3 patients have a better prognosis than previously thought.
EUROPEAN UROLOGY ONCOLOGY
(2023)
Article
Urology & Nephrology
Ming-Jun Shi, Jacqueline Fontugne, Aura Moreno-Vega, Xiang-Yu Meng, Clarice Groeneveld, Florent Dufour, Aurelie Kamoun, Sia Viborg Lindskrog, Luc Cabel, Clementine Krucker, Audrey Rapinat, Claire Dunois-Larde, May-Linda Lepage, Elodie Chapeaublanc, Olivier Levrel, Victoria Dixon, Thierry Lebret, Anna Almeida, Aurelien De Reynies, Natacha Rochel, Lars Dyrskjot, Yves Allory, Francois Radvanyi, Isabelle Bernard-Pierrot
Summary: FGFR3 mutations are associated with male sex bias in bladder cancer. Through studies on a transgenic mouse model, it has been found that FGFR3 mutations can initiate bladder cancer and potentially impact male sex bias through FGFR3-dependent downregulation of estrogen receptor.
Review
Pharmacology & Pharmacy
Chao Tang, Heng Liu, Yanpeng Fan, Jiahao He, Fuqiu Li, Jin Wang, Yuchuan Hou
Summary: Bladder cancer is commonly treated with transurethral resection followed by intravesical chemotherapy, but conventional methods lack selectivity and efficiency. Nanomedicines offer targeted drug delivery with improved efficacy and precision, overcoming the challenges of conventional treatments.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Daniel A. Hescheler, Burkhard Riemann, Milan J. M. Hartmann, Maximilian Michel, Michael Faust, Christiane J. Bruns, Hakan Alakus, Costanza Chiapponi
Summary: This study identified a large number of targetable genes in PTC cases, with varied frequency of BRAF V600 mutation across different PTC subtypes. While some FDA-approved drugs can be used for treating PTC, they are only applicable to a small subset of patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Adlina Roslan, Nurshahira Sulaiman, Khairul Asri Mohd Ghani, Armania Nurdin
Summary: This review discusses the studies on membrane proteins as potential biomarkers for personalized medicine, describing their types and significant functions as potential biomarkers for future medicine.
Article
Medicine, General & Internal
Kelly K. Bree, Yong Shan, Patrick J. Hensley, Niyati Lobo, Chengrui Hu, Douglas S. Tyler, Karim Chamie, Ashish M. Kamat, Stephen B. Williams
Summary: This population-based study found that surveillance testing rates increased over time among patients with low-risk non-muscle-invasive bladder cancer (NMIBC), despite low rates of disease recurrence and progression. The annual cost of care also increased, particularly among patients with recurrent disease.
Article
Oncology
Yao Wang, Yang Zhang, Peng-Chao Li, Jiajie Guo, Fan Huo, Jintao Yang, Ru Jia, Juan Wang, Qiju Huang, Dan Theodorescu, Hanyang Yu, Chao Yan
Summary: Bladder cancer is a common disease worldwide, often presenting as nonmuscle invasive. Multiple recurrences of bladder cancer lead to decreased quality of life and high costs. Targeted intravesical chemotherapy using a bladder cancer-specific aptamer can reduce toxicity and enhance therapeutic efficacy.
Article
Genetics & Heredity
Daowu Yu, Shengwei Liu, Yijun Chen, Lumeng Yang
Summary: This study identified CHEK1 and UBE2C as hub genes related to the progression of breast cancer and found their dysregulation in immune cells and correlation with tumor infiltration.
FRONTIERS IN GENETICS
(2022)
Article
Urology & Nephrology
Lennert Eismann, Lucas Bohn, Alexander Buchner, Jozefina Casuscelli, Yannic Volz, Philipp Weinhold, Christian Wuelfing, Raphaela Waidelich, Christian G. Stief, Boris Schlenker, Severin Rodler
Summary: This study evaluated the impact of chronological and biological age on perioperative complications and survival after RNU. The results showed that with increasing age, the complication rates after RNU increased and the survival period decreased. The combined risk score had predictive value for survival after RNU.
UROLOGIA INTERNATIONALIS
(2022)
Article
Urology & Nephrology
Eva Gresser, Piotr Woznicki, Katharina Messmer, Andrea Schreier, Wolfgang Gerhard Kunz, Michael Ingrisch, Christian Stief, Jens Ricke, Dominik Noerenberg, Alexander Buchner, Gerald Bastian Schulz
Summary: This study aimed to evaluate the performance of quantitative radiomics signatures in the detection of lymph node metastases in bladder cancer. By analyzing 1354 patients who underwent radical cystectomy, it was found that the diagnostic efficacy of radiologist-evaluated CT imaging studies is limited. The results showed that radiomics signatures can accurately discriminate lymph node metastases.
EUROPEAN UROLOGY FOCUS
(2023)
Article
Oncology
Wiebke Werner, Katharina Detjen, Alix Bruneau, Isabella Lurje, Natalie Nestel, Henning Jann, Frank Tacke, Bertram Wiedenmann, Christoph Roderburg, Linda Hammerich
Summary: In a retrospective study on neuroendocrine tumors, the levels of FLT3LG mRNA were found to be correlated with the abundance of immune cells cDC and T cells, which also predicted disease-specific survival. The combination of FLT3LG and T cell counts improved this prediction, suggesting their potential as prognostic markers.
ENDOCRINE-RELATED CANCER
(2023)
Article
Surgery
Amelie Koch, Caroline Quartucci, Alexander Buchner, Boris Schlenker, Armin Becker, Ken Catchpole, Matthias Weigl
Summary: Technological advancements in the operating room have posed challenges for surgical workflow, professionals, and patient safety. This study aimed to explore the associations of intraoperative flow disruptions with patient outcomes, staff workload, and surgery duration.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
Marco Foglar, Maximilian Aumiller, Katja Bochmann, Alexander Buchner, Mohamed El Fahim, Stefanie Quach, Ronald Sroka, Herbert Stepp, Niklas Thon, Robert Forbrig, Adrian Ruehm
Summary: Interstitial photodynamic therapy (iPDT) mediated by 5-aminolevulinic acid (5-ALA) showed promising results in the treatment of glioblastomas, prolonging progression-free survival (PFS) and overall survival (OS). The methylation status of MGMT promoter was found to be the dominant factor affecting prognosis. After iPDT, a characteristic structure (iPDT remnant) appeared in the MRI data.
Article
Oncology
Kristian Unger, Julia Hess, Vera Link, Alexander Buchner, Chukwuka Eze, Minglun Li, Christian Stief, Thomas Kirchner, Frederick Klauschen, Horst Zitzelsberger, Maximilian Niyazi, Ute Ganswindt, Nina-Sophie Schmidt-Hegemann, Claus Belka
Summary: The study analyzed DNA methylation and genomic copy number in primary tumors and lymph node metastases of prostate cancer patients. It found that DNA methylation and histone-mediated methylation were associated with lymphatic spread, and proposed a methylation signature for predicting lymphatic spread in specific patient groups.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Minglun Li, Yourong Fan, Christian Trapp, Nina Sophie Schmidt-Hegemann, Jing Ma, Alexander Buchner, Shun Lu, Bin Xu, Christian Stief, Xuanbin Wang, Cheng Zhou, Claus Belka, Paul Rogowski
Summary: This study evaluated the feasibility of subsequent elective nodal radiotherapy (ENRT) for nodal recurrences after previous radiotherapy with a defined planning approach for a gapless radiation field junction. The results showed that ENRT seems to be feasible, applying the dose constraints without grade 3 acute or late toxicities exceeding baseline.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Isabella Lurje, Nadine T. Gaisa, Ralf Weiskirchen, Frank Tacke
Summary: Fibrosis, a pathological scar tissue formation, can occur in various organs due to different etiologies and contributes to global morbidity and mortality. Common mechanisms involve sustained injury to parenchymal cells triggering a deregulated wound healing response. The transformation of fibroblasts into myofibroblasts with excessive extracellular matrix production is a hallmark of the disease, along with complex cellular interactions involving immune cells, endothelial cells, and parenchymal cells. Mediators such as growth factors, cytokines, and danger-associated molecular patterns play important roles in fibrosis across organs.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Lili Wang, Chen Lyu, Birgit Stadlbauer, Alexander Buchner, Elfriede Noessner, Heike Pohla
Summary: Berbamine targets prostate CSCs and enhances the antitumor effect of cabazitaxel, while reversing cabazitaxel resistance. Additionally, berbamine may regulate the expression of the let-7 family and miR-26b through exosome delivery.
Article
Endocrinology & Metabolism
Thilo Westhofen, Moritz Bensel, Boris Schlenker, Armin Becker, Christian G. Stief, Alexander Kretschmer, Alexander Buchner
Summary: This study aimed to assess the impact of previous inguinal mesh hernioplasty (MH) on metastasis-free survival (MFS), biochemical recurrence-free survival (BRFS), and health-related quality of life (HRQOL) following radical prostatectomy (RP). The findings showed that patients with previous MH had lower MFS and BRFS rates but no significant differences in continence recovery, erectile function recovery, and general HRQOL.
Article
Oncology
Lennert Eismann, Philipp von Walter, Andreas Jung, Michael Chaloupka, Severin Rodler, Thilo Westhofen, Alexander Buchner, Christian G. Stief, Thomas Stadler, Boris Schlenker
Summary: In this study, we investigated the methylation status of tumor-associated genes in patients with prostate cancer who underwent radical prostatectomy. The results showed that methylation status has the potential to be used as a diagnostic and predictive tool in prostate cancer. Specifically, hypermethylation of APC, RASSF1, TNFRFS10c, and RUNX3 were identified as novel PCa-specific biomarkers.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Oncology
Isabella Lurje, Deniz Uluk, Sandra Pavicevic, Minh Duc Phan, Dennis Eurich, Uli Fehrenbach, Dominik Geisel, Timo Alexander Auer, Uwe Pelzer, Dominik Paul Modest, Nathanael Raschzok, Igor Maximilian Sauer, Wenzel Schoening, Frank Tacke, Johann Pratschke, Georg Lurje
Summary: This study investigated the prognostic value of body composition in patients with intrahepatic cholangiocarcinoma (iCCA). The results showed that alterations in muscle mass and adipose tissue, as well as metabolic-associated fatty liver disease (MAFLD), were associated with prognosis. However, only age and transfusions were independent predictors of overall survival.
Article
Immunology
Chen Lyu, Birgit Stadlbauer, Lili Wang, Alexander Buchner, Heike Pohla
Summary: The management of ccRCC has changed rapidly with the introduction of ICIs, but many patients develop resistance to therapy. This study identifies shikonin as a promising combination partner with ipilimumab for the treatment of ccRCC, showing strong inhibitory effects on CSCs and activation of CD8+ and CD4+ T cells. Additionally, VCAM1 is identified as a potential immunotherapeutic target and novel CSC marker for ccRCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Dorothea Strobach, Lisa Haimerl, Hanna Mannell, Christian G. Stief, Alexander Karl, Tobias Grimm, Alexander Buchner
Summary: Through an observational study of bladder cancer patients, it was found that non-oncologic drug therapy has a certain impact on recurrence-free and cancer-specific survival. Polypharmacy, calcium channel blockers, and proton pump inhibitors have a negative impact on recurrence-free in patients who underwent radical cystectomy, while statins have a positive effect on recurrence-free in patients with a first diagnosis. Angiotensin-converting enzyme inhibitors and magnesium have a negative impact on cancer-specific survival in patients with a first diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Urology & Nephrology
T. Westhofen, A. Buchner, B. Schlenker, A. Becker, C. G. Stief, A. Kretschmer