FUT4 is involved in PD-1-related immunosuppression and leads to worse survival in patients with operable lung adenocarcinoma

CD103 + CD8 + T lymphocytes in non-small cell lung cancer are phenotypically and functionally primed to respond to PD-1 blockade

(2018) Peiliang Wang et al.   CELLULAR IMMUNOLOGY

A Four-Factor Immunoscore System That Predicts Clinical Outcome for Stage II/III Gastric Cancer

(2017) Ti Wen et al.   Cancer Immunology Research

Increased fucosylation has a pivotal role in multidrug resistance of breast cancer cells through miR-224-3p targeting FUT4

(2016) Xiaobin Feng et al.   GENE

PD1 and PDL1 expression in primary central nervous system diffuse large B-cell lymphoma are frequent and expression of PD1 predicts poor survival

(2016) Marion Four et al.   HEMATOLOGICAL ONCOLOGY

Pembrolizumab for patients with PD-L1-positive advanced gastric cancer (KEYNOTE-012): a multicentre, open-label, phase 1b trial

(2016) Kei Muro et al.   LANCET ONCOLOGY

Fucosyltransferase-4 and Oligosaccharide Lewis Y Antigen as potentially Correlative Biomarkers of Helicobacter pylori CagA Associated Gastric Cancer

(2016) Faisal Aziz et al.   PATHOLOGY & ONCOLOGY RESEARCH

Radiomics Signature: A Potential Biomarker for the Prediction of Disease-Free Survival in Early-Stage (I or II) Non—Small Cell Lung Cancer

(2016) Yanqi Huang et al.   RADIOLOGY

Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions

(2016) Faisal Aziz et al.   TOXICOLOGY IN VITRO

Prognostic value of PD-L1 and PD-1 expression in pulmonary neuroendocrine tumors

(2016) Yangwei Fan et al.   OncoTargets and Therapy

Analysis of the immune microenvironment in resected non-small cell lung cancer: the prognostic value of different T lymphocyte markers

(2016) Marta Usó et al.   Oncotarget

Fucosyltransferase IV (FUT4) as an effective biomarker for the diagnosis of breast cancer

(2015) Xiaomei Yan et al.   BIOMEDICINE & PHARMACOTHERAPY

Posttranslational modification of E-cadherin by core fucosylation regulates Src activation and induces epithelial–mesenchymal transition-like process in lung cancer cells

(2015) Kang Shao et al.   GLYCOBIOLOGY

Low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384

(2015) Juxiang Huang et al.   IMMUNOLOGIC RESEARCH

Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death

(2015) XIU SHAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression

(2015) XIU SHAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Cancer-related CD15/FUT4 overexpression decreases benefit to agents targeting EGFR or VEGF acting as a novel RAF-MEK-ERK kinase downstream regulator in metastatic colorectal cancer

(2015) Guido Giordano et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

VEGF-A modulates expression of inhibitory checkpoints on CD8+T cells in tumors

(2015) Thibault Voron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer

(2015) Hossein Borghaei et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression of Fucosyltransferase 8 Is Associated with an Unfavorable Clinical Outcome in Non-Small Cell Lung Cancers

(2015) Rio Honma et al.   ONCOLOGY

New immunotherapies targeting the PD-1 pathway

(2015) Jordan M. Chinai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pattern of CD14+ Follicular Dendritic Cells and PD1+ T Cells Independently Predicts Time to Transformation in Follicular Lymphoma

(2014) J. P. Smeltzer et al.   CLINICAL CANCER RESEARCH

The Common  -Chain Cytokines IL-2, IL-7, IL-15, and IL-21 Induce the Expression of Programmed Death-1 and Its Ligands

(2014) A. L. Kinter et al.   JOURNAL OF IMMUNOLOGY

STAT3, STAT4, NFATc1, and CTCF Regulate PD-1 through Multiple Novel Regulatory Regions in Murine T Cells

(2014) J. W. Austin et al.   JOURNAL OF IMMUNOLOGY

Tumor-infiltrating PD1-Positive Lymphocytes and FoxP3-Positive Regulatory T Cells Predict Distant Metastatic Relapse and Survival of Clear Cell Renal Cell Carcinoma

(2014) Myoung Jae Kang et al.   Translational Oncology

LIF upregulates poFUT1 expression and promotes trophoblast cell migration and invasion at the fetal–maternal interface

(2014) S Liu et al.   Cell Death & Disease

A Circulating Subpopulation of Monocytic Myeloid-Derived Suppressor Cells as an Independent Prognostic/Predictive Factor in Untreated Non-Small Lung Cancer Patients

(2014) Eleni-Kyriaki Vetsika et al.   Journal of Immunology Research

HSF1 and Sp1 Regulate FUT4 Gene Expression and Cell Proliferation in Breast Cancer Cells

(2013) Xuesong Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The diagnostic accuracy of pleural effusion and plasma samples versus tumour tissue for detection of EGFR mutation in patients with advanced non-small cell lung cancer: comparison of methodologies

(2013) Xiaoqing Liu et al.   JOURNAL OF CLINICAL PATHOLOGY

Management of non-small-cell lung cancer: recent developments

(2013) Martin Reck et al.   LANCET

Tumor Infiltrating PD1-Positive Lymphocytes and the Expression of PD-L1 Predict Poor Prognosis of Soft Tissue Sarcomas

(2013) Jung Ryul Kim et al.   PLoS One

Role of fucosyltransferase IV in epithelial–mesenchymal transition in breast cancer cells

(2013) X Yang et al.   Cell Death & Disease

A novel role for inducible Fut2 in angiogenesis

(2012) Pei-Suen Tsou et al.   ANGIOGENESIS

Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

(2012) Marcin Imielinski et al.   CELL

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fucosyltransferase 8 as a functional regulator of nonsmall cell lung cancer

(2012) C.-Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The recombinant lectin-like domain of thrombomodulin inhibits angiogenesis through interaction with Lewis Y antigen

(2011) C.-H. Kuo et al.   BLOOD

Neutrophil interactions with sialyl Lewis X on human nonsmall cell lung carcinoma cells regulate invasive behavior

(2011) Catherine A. St. Hill et al.   CANCER

Selectin Ligand Sialyl-Lewis x Antigen Drives Metastasis of Hormone-Dependent Breast Cancers

(2011) S. Julien et al.   CANCER RESEARCH

Regulation of glycosyltransferases and Lewis antigens expression by IL-1β and IL-6 in human gastric cancer cells

(2011) Mercè Padró et al.   GLYCOCONJUGATE JOURNAL

Myeloid derived suppressor cells in human diseases

(2011) Tim F. Greten et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Early stage and locally advanced (non-metastatic) non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2010) L. Crino et al.   ANNALS OF ONCOLOGY

Frequency of regulatory T cells in peripheral blood and in tumour-infiltrating lymphocytes correlates with poor prognosis in renal cell carcinoma

(2010) Francesco Liotta et al.   BJU INTERNATIONAL

Overexpression of fucosyltransferase IV promotes A431 cell proliferation through activating MAPK and PI3K/Akt signaling pathways

(2010) Xue-Song Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy

(2008) C. Marcela Diaz-Montero et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Strategies for use of IL-10 or its antagonists in human disease

(2008) Anne O'Garra et al.   IMMUNOLOGICAL REVIEWS

Suppression of FUT1/FUT4 expression by siRNA inhibits tumor growth

(2007) Zhenbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Identification of genes with abnormal expression changes in acute myeloid leukemia

(2007) Derek L. Stirewalt et al.   GENES CHROMOSOMES & CANCER