Article
Neurosciences
Satoshi Iwasaki, Yuji Ikegaya
Summary: This study demonstrates that precise activation of a specific neuron ensemble in the hippocampus is crucial for memory retrieval, while noisy activity of memory-irrelevant neurons can easily disrupt this process.
Review
Biochemistry & Molecular Biology
Hee Ra Park, Mudan Cai, Eun Jin Yang
Summary: Fear memory is crucial for avoiding harm, but excessive consolidation can lead to post-traumatic stress disorder and anxiety-related disorders. Dysregulation of specific brain regions and neural circuits, such as the hippocampus, amygdala, and medial prefrontal cortex, has been observed in patients with these disorders. These regions are important for learning, memory, and integration, and play a significant role in neural plasticity and structural remodeling in psychiatric disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Weronika Szadzinska, Konrad Danielewski, Kacper Kondrakiewicz, Karolina Andraka, Evgeni Nikolaev, Marta Mikosz, Ewelina Knapska
Summary: Fear extinction training gradually changes the vHIP-PL connectivity, allowing for fear suppression. In the absence of fear suppression from the vHIP, signals from the BL play a dominant role, resulting in heightened fear levels.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Jung Hoon Jung, Ying Wang, Andrew J. Mocle, Tao Zhang, Stefan Kohler, Paul W. Frankland, Sheena A. Josselyn
Summary: According to the encoding specificity hypothesis, memory is best recalled by retrieval cues that overlap with training cues. This hypothesis is supported by human studies. In this study, engrams in mice were visualized to test whether retrieval cues that overlap with training cues produce maximal memory recall via high engram reactivation. The findings support the encoding specificity hypothesis and emphasize the interaction between stored information (engram) and cues available at memory retrieval (ecphory).
Article
Neurosciences
Abha K. Rajbhandari, Christopher J. Octeau, Sarah Gonzalez, Zachary T. Pennington, Farzanna Mohamed, Jeremy Trott, Jasmine Chavez, Erin Ngyuen, Natasha Keces, Weizhe Z. Hong, Rachael L. Neve, James Waschek, Baljit S. Khakh, Michael S. Fanselow
Summary: Trauma can lead to dysfunctional fear regulation and development of disorders like PTSD. Research in mice showed that the PACAPergic pathway can modulate fear and fear extinction. Selective deletion of PAC1 receptors in mICCs in females may affect fear acquisition, generalization, and extinction, with modulation dependent on behavioral state.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Xiaoyan Ding, Mengdie Yang, Ning Wu, Jin Li, Rui Song
Summary: Abnormal fear memory can lead to stress disorders such as PTSD. Therefore, intervention in the formation of abnormal fear memory can be a new strategy for preventing and treating PTSD.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Bridget L. Kajs, Adrienne C. Loewke, Jeffrey M. Dorsch, Leah T. Vinson, Lisa A. Gunaydin
Summary: This study utilized fiber photometry to record the activity of the dorsomedial prefrontal cortex (dmPFC) and its projections to the dorsomedial striatum (DMS) and basolateral amygdala (BLA) during active avoidance learning in mice. The results showed that both prefrontal projections exhibited learning-related increases in activity, while the overall dmPFC activity showed different patterns during avoidance and cued freezing. The findings highlight the importance of dmPFC projections in active avoidance learning.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Mitjan Morr, Jeanine Noell, Daphne Sassin, Jule Daniels, Alexandra Philipsen, Benjamin Becker, Birgit Stoffel-Wagner, Rene Hurlemann, Dirk Scheele
Summary: Loneliness may contribute to vulnerability to intrusive memories after trauma in healthy men, with altered limbic processing of fear signals being a potential underlying mechanism. Lonely men showed more intrusions and altered amygdala activity, while loneliness did not have the same impact on women.
Article
Biochemistry & Molecular Biology
Seung-Woo Jin, Inah Lee
Summary: The study found that in goal-directed tasks, the intermediate region of the hippocampus plays a key role in representing changes in the motivational significance of a place, especially when the motivational significance decreases, place cells remap and dynamically shift towards high-value locations.
Article
Neurosciences
Tomoki Kurikawa, Kenji Mizuseki, Tomoki Fukai
Summary: Researchers constructed a neural network model to explore how the brain processes information during spatial working memory tasks, finding that cholinergic modulation regulates information flow in different memory task stages, and theta oscillation coordinates interactions between various brain regions. The model predicts that the MEC plays a significant role in decoding and encoding spatial memory.
Article
Neurosciences
Ana Oliveira, Marcia Azevedo, Rafaela Seixas, Raquel Martinho, Paula Serrao, Monica Moreira-Rodrigues
Summary: Adrenaline and glucose released during stress may strengthen contextual fear memory. Glucose can enhance contextual fear memory independently of adrenaline in Ad-deficient mice, possibly through increased gene expression in the hippocampus. Additionally, adrenaline and glucose may act synergistically to strengthen contextual fear memory.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Mario A. Penzo, Justin M. Moscarello
Summary: Plasticity induced by fear conditioning plays a role in storing aversive associative memories, and central nucleus of the amygdala (CeA) exhibits experience-dependent synaptic plasticity that guides the selection of defensive programs in response to acquired threats. The CeA may exemplify how synaptic plasticity at specific nodes of a distributed network contributes complementarily to distinct memory processes.
TRENDS IN NEUROSCIENCES
(2023)
Article
Behavioral Sciences
Ayako Kawaminami, Daisuke Yamada, Shoko Yanagisawa, Motoki Shirakata, Keita Iio, Hiroshi Nagase, Akiyoshi Saitoh
Summary: KNT-127, a selective agonist of the delta-opioid receptor (DOP), has been shown to facilitate fear extinction in mice. This study identified the basolateral nucleus of the amygdala (BLA) and infralimbic subregion of the medial prefrontal cortex (IL) as the brain regions where KNT-127 reduces freezing response during fear memory testing. The effect of KNT-127 was mediated by MEK/ERK signaling in the BLA, PI3K/Akt signaling in the IL, and DOPs in both brain regions.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Lizhu Jiang, Chao Liu, Baizhen Zhao, Chen Ma, Yan Yin, Qixin Zhou, Lin Xu, RongRong Mao
Summary: Fear memory in different species shows time-dependent alterations. This study found that training during the lower activation period of hippocampal Rac1 at night improves contextual fear memory in rats. Exogenous melatonin treatment enhances Rac1 activity and impairs fear memory acquisition during the night, while a Rac1-specific inhibitor attenuates the effect of melatonin.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Neurosciences
Konstanze Simbriger, Ines S. Amorim, Gilliard Lach, Kleanthi Chalkiadaki, Stella Kouloulia, Seyed Mehdi Jafarnejad, Arkady Khoutorsky, Christos G. Gkogkas
Summary: Contextual fear conditioning is a common behavioral paradigm used in neuroscience research to study the mechanisms of learning and memory. Using ribosome profiling, a study demonstrated that an immediate shock in male mice leads to translational and transcriptional changes in Immediate Early Genes in the dorsal hippocampus, an effect often overlooked in research.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Neurosciences
Woong Bin Kim, Jun-Hyeong Cho
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Woong Bin Kim, Jun-Hyeong Cho
Article
Cell & Tissue Engineering
Miles Cunningham, Jun-Hyeong Cho, Amanda Leung, George Savvidis, Sandra Ahn, Minho Moon, Paula K. J. Lee, Jason J. Han, Nima Azimi, Kwang-Soo Kim, Vadim Y. Bolshakov, Sangmi Chung
Article
Neurosciences
Jun-Hyeong Cho, Candice C. Askwith
JOURNAL OF NEUROPHYSIOLOGY
(2008)
Article
Neurosciences
Jun-Hyeong Cho, Ko Zushida, Gleb P. Shumyatsky, William A. Carlezon, Edward G. Meloni, Vadim Y. Bolshakov
JOURNAL OF NEUROSCIENCE
(2012)
Article
Neurosciences
Jun-Hyeong Cho, Ildar T. Bayazitov, Edward G. Meloni, Karyn M. Myers, William A. Carlezon, Stanislav S. Zakharenko, Vadim Y. Bolshakov
NATURE NEUROSCIENCE
(2012)
Article
Neurosciences
Jun-Hyeong Cho, Karl Deisseroth, Vadim Y. Bolshakov
Article
Multidisciplinary Sciences
Ryong-Moon Shin, Keith Tully, Yan Li, Jun-Hyeong Cho, Makoto Higuchi, Tetsuya Suhara, Vadim Y. Bolshakov
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2010)
Article
Cell & Tissue Engineering
Tae-Gon Kim, Ruiqin Yao, Travis Monnell, Jun-Hyeong Cho, Anju Vasudevan, Alice Koh, Peeyush T. Kumar, Minho Moon, Debkanya Datta, Vadim Y. Bolshakov, Kwang-Soo Kim, Sangmi Chung
Article
Neurosciences
Zhicheng Shao, Haneul Noh, Woong Bin Kim, Peiyan Ni, Christine Nguyen, Sarah E. Cote, Elizabeth Noyes, Joyce Zhao, Teagan Parsons, James M. Park, Kelvin Zheng, Joshua J. Park, Joseph T. Coyle, Daniel R. Weinberger, Richard E. Straub, Karen F. Berman, Jose Apud, Dost Ongur, Bruce M. Cohen, Donna L. McPhie, Judith L. Rapoport, Roy H. Perlis, Thomas A. Lanz, Hualin Simon Xi, Changhong Yin, Weihua Huang, Teruyoshi Hirayama, Emi Fukuda, Takeshi Yagi, Sulagna Ghosh, Kevin C. Eggan, Hae-Young Kim, Leonard M. Eisenberg, Alexander A. Moghadam, Patric K. Stanton, Jun-Hyeong Cho, Sangmi Chung
NATURE NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Dongxin Liu, Amy Zinski, Akanksha Mishra, Haneul Noh, Gun-Hoo Park, Yiren Qin, Oshoname Olorife, James M. Park, Chiderah P. Abani, Joy S. Park, Janice Fung, Farah Sawaqed, Joseph T. Coyle, Eli Stahl, Jaroslav Bendl, John F. Fullard, Panos Roussos, Xiaolei Zhang, Patric K. Stanton, Changhong Yin, Weihua Huang, Hae-Young Kim, Hyejung Won, Jun-Hyeong Cho, Sangmi Chung
Summary: This study uncovers cell type-specific and developmental stage-specific mechanisms of schizophrenia risk gene function, providing insights into mechanism-based novel therapeutic targets.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Ji-Hye Lee, Woong Bin Kim, Eui Ho Park, Jun-Hyeong Cho
Summary: The consolidation process of remote contextual fear memories in mice involves the strengthening of excitatory connections between prefrontal cortical (PFC) engram neurons that were active during learning and reactivated during remote memory recall. The extinction of remote memories weakens these synapses. The synapse-specific plasticity is dependent on CREB and requires sustained hippocampal signals, which can be conveyed to PFC by the retrosplenial cortex. The strong connection between PFC engram neurons and other PFC neurons recruited during remote memory recall is also observed.
NATURE NEUROSCIENCE
(2023)
Article
Cell Biology
Jun-Hyeong Cho, Candice C. Askwith
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2007)