Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell–derived cortical interneurons from subjects with schizophrenia

The protocadherin alpha cluster is required for axon extension and myelination in the developing central nervous system

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Pathological Basis for Deficient Excitatory Drive to Cortical Parvalbumin Interneurons in Schizophrenia

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Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

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Gene expression elucidates functional impact of polygenic risk for schizophrenia

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Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells

(2016) Aaron Topol et al.   Cell Reports

Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting

(2016) Sonoko Hasegawa et al.   Frontiers in Molecular Neuroscience

Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1

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Decreased synaptic and mitochondrial density in the postmortem anterior cingulate cortex in schizophrenia

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The GABA System in Schizophrenia: Cells, Molecules and Microcircuitry

(2015) Francine M. Benes   SCHIZOPHRENIA RESEARCH

Using theRPackagecrlmmfor Genotyping and Copy Number Estimation

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iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging

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Biological insights from 108 schizophrenia-associated genetic loci

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Early Developmental Disturbances of Cortical Inhibitory Neurons: Contribution to Cognitive Deficits in Schizophrenia

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Interneurons from Embryonic Development to Cell-Based Therapy

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Efficient Specification of Interneurons from Human Pluripotent Stem Cells by Dorsoventral and Rostrocaudal Modulation

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Successful therapies for Alzheimer’s disease: why so many in animal models and none in humans?

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Synaptic Encoding of Fear Extinction in mPFC-amygdala Circuits

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Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

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γ-Protocadherins Control Cortical Dendrite Arborization by Regulating the Activity of a FAK/PKC/MARCKS Signaling Pathway

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Use of Postmortem Human Dura Mater and Scalp for Deriving Human Fibroblast Cultures

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Double-blind, randomized, placebo-controlled 6-week study on the efficacy and safety of the tamoxifen adjunctive to lithium in acute bipolar mania

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Cognitive Improvement by Activation of α7 Nicotinic Acetylcholine Receptors: From Animal Models to Human Pathophysiology

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Protocadherin-  Family Is Required for Serotonergic Projections to Appropriately Innervate Target Brain Areas

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Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes

(2009) Juan E Belforte et al.   NATURE NEUROSCIENCE

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

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Subunit-Selective Modulation of GABA Type A Receptor Neurotransmission and Cognition in Schizophrenia

(2008) David A. Lewis et al.   AMERICAN JOURNAL OF PSYCHIATRY

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Down-regulation of protocadherin-α A isoforms in mice changes contextual fear conditioning and spatial working memory

(2008) Emi Fukuda et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

α- and γ-Protocadherins Negatively Regulate PYK2

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The protocadherin-α family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse

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