Article
Oncology
Wenjing He, Yi Hu, Dan Chen, Yijia Li, Dongmei Ye, Qiang Zhao, Li Lin, Xiaomin Shi, Ligong Lu, Zhinan Yin, Xiaoshun He, Yifang Gao, Yangzhe Wu
Summary: This study reported the dysfunctional features of γδ T cells in hepatocellular carcinoma (HCC) within the tumor microenvironment, providing scientific support for the use of allogeneic V delta 2(+) γδ T cells in HCC immunotherapy.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Hui Shao, Henry J. Kaplan, Deming Sun
Summary: Autoimmune diseases caused by T cells can originate from either Th1 or Th17-type pathogenic T cells, but it is uncertain whether they are influenced by distinct pathogenic factors and whether treatments effective for Th1 responses work for Th17 responses. Through a systematic analysis in a mouse model of experimental autoimmune uveitis (EAU), it was found that these two pathogenic responses differ significantly in their pathological progressions and treatment susceptibility.
Review
Immunology
Wen Hou, Xiaoli Wu
Summary: This study investigates the roles of gamma delta T cells in HBV and HCV infections, discussing the different roles they play in the progression of liver diseases at various stages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Lihua Deng, Anna Harms, Sarina Ravens, Immo Prinz, Likai Tan
Summary: The heterogeneity of V delta 2(+) TCRs is primarily determined by TRDJ-usage and the length of CDR3aa sequences. Public V delta 2(+) TCRs result from germline-like rearrangement and synonymous codons, and they are associated with a higher expansion status.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Li Lin, Yan Chen, Dan Chen, Junxiang Shu, Yi Hu, Zhinan Yin, Yangzhe Wu
Summary: This study proposes a method called 40 degrees C-shock, which can enhance the cytotoxic function of V delta 2(+) gamma delta T cells. The researchers found that 40 degrees C-shock can phosphorylate proteins ERK and p38 through HSP70, leading to various cellular changes that enhance cytotoxicity, including increased cell surface adhesion, elevated expression of cytokines, and downregulated expression of LAG3. This study provides important evidence for improving tumor immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Immunology
Nicola Herold, Anna Schollhorn, Adrian Feile, Andrea Gaissler, Anne Mohrholz, Graham Pawelec, Markus W. Loeffler, Stoyan Dimitrov, Cecile Gouttefangeas, Kilian Wistuba-Hamprecht
Summary: This study investigates the applicability of m24 antibody in the detection of gamma delta T cell activation. The results show that m24 antibody staining is associated with cytokine expression and allows for rapid assessment of activation, eliminating the need for intracellular staining or protein trafficking inhibitors.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Cell Biology
Nicola Beucke, Svenja Wingerter, Karin Haehnel, Lisbeth Aagaard Larsen, Kaare Christensen, Graham Pawelec, Kilian Wistuba-Hamprecht
Summary: The study found that latent cytomegalovirus infection affects the differentiation status of alpha beta and gamma delta T cells in humans. Additionally, genetic factors also influence the differentiation of gamma delta and alpha beta T cell subsets.
Article
Immunology
Zilong Wang, Xiaoxiao Wang, Rui Jin, Feng Liu, Huiying Rao, Lai Wei, Hongsong Chen, Bo Feng
Summary: The expression of lysosome-associated membrane glycoprotein 3 (LAMP3) is upregulated in chronic hepatitis B (CHB) patients, and it is associated with T cell activation, chemokine signaling pathway, and infiltrating immune cells. High LAMP3 expression is also linked to liver dysfunction.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Xueping Yu, Yijuan Zheng, Dawu Zeng, Yongjun Zhou, Jian Sun, Milong Su, Huatang Zhang, Minhui Zheng, Zhipeng Huang, Wenwu Lin, Richeng Mao, Jiming Zhang, Chunfu Zheng, Zhijun Su
Summary: CD3(+)CD4(-)CD7(+)CD57(-) T cells are decreased in patients with end-stage liver disease, especially those with acute to chronic liver failure, and this decrease is associated with disease severity, prognosis, and complications. IL-22 stimulation promotes apoptosis and reduces the number of CD3(+)CD4(-)CD7(+)CD57(-) T cells. These cells exhibit an immunosuppressive phenotype and low expression levels of cytokines.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Immunology
Ning Huang, Hao Dong, Yuqi Luo, Bin Shao
Summary: Periodontitis is a chronic disease driven by pathogens and inflammation, modulated by the immune system, particularly Th17 cells. Th17 cells play a key role in driving periodontal inflammation and their cytokines are major players in the pathogenesis of periodontitis. Understanding regulators of Th17 cells is crucial for potential clinical interventions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Lanman Xu, Xiaofang Wang, Yan Chen, Lynn Soong, Yongping Chen, Jiyang Cai, Yuejin Liang, Jiaren Sun
Summary: The study found that metformin has a protective effect against liver injury in acute viral hepatitis by modulating effector T cell activation through regulating the mTORC1 pathway and mitochondrial functions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Stephane Fattori, Laurent Gorvel, Samuel Granjeaud, Philippe Rochigneux, Marie-Sarah Rouviere, Amira Ben Amara, Nicolas Boucherit, Magali Paul, Marie Melanie Dauplat, Jeanne Thomassin-Piana, Maria Paciencia-Gros, Morgan Avenin, Jihane Pakradouni, Julien Barrou, Emmanuelle Charafe-Jauffret, Gilles Houvenaeghel, Eric Lambaudie, Francois Bertucci, Anthony Goncalves, Carole Tarpin, Jacques A. Nunes, Raynier Devillier, Anne-Sophie Chretien, Daniel Olive
Summary: The study found that phenotypic alterations of circulating V delta 2(+) gamma delta T cells in peripheral blood of breast cancer patients were already established at diagnosis and related to tumor progression. Terminally differentiated V delta 2(+) gamma delta T cells expressing markers of senescence and exhaustion were significantly associated with lymph node invasion. This supports the involvement of V delta 2(+) gamma delta T cells in breast cancer pathogenesis and progression, highlighting the potential of liquid biopsies to monitor tumor-infiltrating immune cells.
Review
Cell Biology
Lingfeng Qiu, Yixi Zhang, Xun Zeng
Summary: The purpose of this review is to discuss the role of gamma delta T cells in humoral immune responses. Accumulating evidence indicates that gamma delta T cells, independent of alpha beta T cells, participate in multiple steps of humoral immunity, including B cell maturation, activation and differentiation, antibody production and class switching. Gamma delta T cells affect B cell function by directly interacting with B cells, secreting cytokines, or modulating alpha beta T cells.
INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Rebecca L. O'Brien, Jennifer Matsuda, M. Kemal Aydintug, Niyun Jin, Swati Phalke, Willi K. Born
Summary: Previous studies have shown inconsistent results regarding the role of gamma delta T cells in the development of type 1 diabetes. This study focused on NOD mice and found that NOD V γ4+ γδ T cells inhibit diabetes development, while NOD V γ1+ cells promote it. Additionally, changes in the abundance of other T cell types were observed in NOD mice deficient in specific gamma delta T cell subsets.
Article
Biochemistry & Molecular Biology
Payal Damani-Yokota, Fengqiu Zhang, Alexandria Gillespie, Haeree Park, Amy Burnside, Janice C. Telfer, Cynthia L. Baldwin
Summary: Gamma delta T cells are a significant component of lymphocytes in the blood of ruminants, with the majority expressing glycoproteins from the WC1 family. Based on the expression of WC1 genes, WC1(+) gamma delta T cells can be divided into WC1.1(+) and WC1.2(+) subpopulations, which differ in their response to specific pathogens. This study shows that these subpopulations are established in the thymus and have different transcriptional programming. The role of the transcription factor SOX-13 in the development of these subpopulations and the gene networks involved are still unknown.
MOLECULAR IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yangyang Cai, Dezhong Lv, Donghao Li, Jiaqi Yin, Yingying Ma, Ya Luo, Limei Fu, Na Ding, Yongsheng Li, Zhenwei Pan, Xia Li, Juan Xu
Summary: IEAtlas is a valuable resource for investigating the immunogenic capacity of non-canonical epitopes and their potential as therapeutic cancer vaccines.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Medicine, Research & Experimental
Zan-Xiong Chen, Hong-Qian Liu, Zhen-Hua Wu, Jun-Lian He, Hao-Jie Zhong
Summary: This study found that the frequency of circulating ILC3s is elevated in patients with HUA and is positively correlated with serum uric acid and creatinine levels. Although there is no significant difference in plasma IL-17A concentration between HUA patients and healthy controls, positive correlations between plasma IL-17A and serum uric acid levels and circulating ILC3 frequency were observed in HUA patients.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Letter
Otorhinolaryngology
Thomas J. Lepley, Zhenxing Wu, Zachary T. Root, Barak M. Spector, Robbie J. Chapman, Aspen R. Schneller, Kathleen Kelly, Bradley A. Otto, Kai Zhao
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Optics
Jing Bai, Xuan Liu, Cheng-xian Ge, Zhen-sen Wu, Xiao-xiao Zhang
Summary: We studied the optical trapping force exerted on non-uniform chiral stratified spheres using a high-order Bessel beam. By comparing with existing reference, we validated the present theories. Numerical simulations considering various parameters showed that different chirality distributions significantly affect the trapping characteristics, and a stable three-dimensional capture can be achieved by selecting appropriate incident beam and particle parameters. These theoretical investigations offer an analytical method for understanding the interaction between light and more complex stratified chiral cells, thus providing an encouraging approach for designing better optical manipulation systems.
Article
Rheumatology
Yang Hu, Rui-Chen Gao, Ni Sang, Li Wu, Pei-Li Shi, Guo-Cui Wu
Summary: Self-disclosure may enhance positive illness perceptions. Social support, drinking, and depression are influential factors for self-disclosure in patients with systemic lupus erythematosus (SLE). Self-disclosure is positively correlated with quality of life, except for physical health and fatigue.
Article
Chemistry, Physical
Guanghui Li, Fengman Liu, Shengyi Yang, Jiang-Tao Liu, Weimin Li, Zhenhua Wu
Summary: The micro-electromechanical-system (MEMS) force and acceleration sensor, based on the graphene-induced non-radiative transition, was investigated using analytical solution and finite element analysis methods. The sensor can detect the deflection of the graphene ribbon, applied force, and acceleration with high sensitivity. With its small size and ability to be charged by light irradiation, the MEMS sensor has significant application prospects in the fields of micro-smart devices, wearable devices, and biomedical systems.
Article
Gastroenterology & Hepatology
Lin Han, Ang Huang, Jinjun Chen, Guangju Teng, Ying Sun, Binxia Chang, Hong-Li Liu, Manman Xu, Xiaoqin Lan, Qingsheng Liang, Jun Zhao, Hui Tian, Songhai Chen, Yun Zhu, Huan Xie, Tong Dang, Jing Wang, Ning Li, Xiaoxia Wang, Yu Chen, Yong-Feng Yang, Dong Ji, Zhengsheng Zou
Summary: This study aims to identify high-risk factors for non-acetaminophen (APAP) drug-induced acute liver failure (ALF) and develop a predictive model for transplant-free survival (TFS). Analysis of 482 patients with non-APAP drug-induced ALF revealed herbal and dietary supplements (HDS) as the most common causative agents. The DIALF-5 model, based on easily identifiable clinical data, accurately predicts 21-day TFS.
HEPATOLOGY INTERNATIONAL
(2023)
Correction
Multidisciplinary Sciences
Robert. D. D. Bell, Ethan. A. A. Winkler, Itender Singh, Abhay. P. P. Sagare, Rashid Deane, Zhenhua Wu, David. M. M. Holtzman, Christer Betsholtz, Annika Armulik, Jan Sallstrom, Bradford. C. C. Berk, Berislav. V. V. Zlokovic
Article
Optics
Shaojie Chang, Zhenhua Wu, Diwei Liu, Renbin Zhong, Zhaoyun Duan, Yanyu Wei, Yubin Gong, Min Hu
Summary: In this study, we propose a novel approach to enhance the second harmonic of electron beams and increase the output power at higher frequencies. By using a planar grating for fundamental modulation and a transmission grating for harmonic coupling, the proposed structure achieves a high power output of the second harmonic signal. Computational investigations demonstrate that this configuration can generate a 0.202 THz signal with an output power of 4.59 W at an electron beam density of 50 A/cm2 and a voltage of 31.5 kV. The reduced current density in the G-band has significant implications for the advancement of terahertz vacuum devices.
Article
Optics
Yanli Xu, Shengyi Yang, Rong Li, Shanjin Lv, Zhenhua Wu, Jiangtao Liu
Summary: Most UV passive optics lack tunability and external modulation methods due to poor tunability of wide-bandgap semiconductor materials in UV working media. This study explores the excitation of magnetic dipole resonances in the solar-blind UV region using hafnium oxide metasurfaces and elastic dielectric polydimethylsiloxane (PDMS). The near-field interactions between the resonant dielectric elements can be modulated by mechanical strain of the PDMS substrate, enabling the flattening of resonant peak beyond the solar-blind UV wavelength range and switching on or off the optical switch in the solar-blind UV region. The device offers a simple design and can be applied in UV polarization modulation, optical communications, and spectroscopy.
Article
Plant Sciences
Zhenhua Wu, Yunpeng Bai, Yujuan Qi, Chao Chang, Yan Jiao, Yaobang Bai, Zhigang Guo
Summary: This study found that metformin has a protective effect against ferroptosis in cardiac ischemia and reperfusion (I/R) injury.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Chemistry, Physical
Meng Li, Hao Chen, Can Guo, Shangshu Qian, Hongpeng Li, Zhenzhen Wu, Chao Xing, Pan Xue, Shanqing Zhang
Summary: To address the issues of lithium-sulfur batteries, a dual interfacial engineering strategy is proposed. For the cathode, iminated polyaniline (iPANI) is used to achieve energetic and morphological engineering. For the anode, the iPANI@rGO-CNTs composite facilitates uniform deposition of lithium-ions, preventing dendrite growth. With the synergic effects of iPANI@rGO-CNTs nanoreactors, the prepared LSBs exhibit excellent rate capability and cycling life, potentially leading to commercialization.
ADVANCED ENERGY MATERIALS
(2023)
Review
Nanoscience & Nanotechnology
Yuhui Tian, Daijie Deng, Li Xu, Meng Li, Hao Chen, Zhenzhen Wu, Shanqing Zhang
Summary: A sustainable and cost-effective production of H2O2 via electrochemical oxygen reduction reaction is highly desired for various applications. Significant progress has been made in catalyst design and innovative cell designs for electrocatalytic production of H2O2. This review summarizes recent advances, including mechanistic explorations, theoretical computations, experimental evaluations, and perspectives on addressing remaining challenges.
NANO-MICRO LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Mengting Zheng, Juncheng Wang, Shangshu Qian, Qiang Sun, Hao Chen, Liang Zhang, Zhenzhen Wu, Shanqing Zhang, Tiefeng Liu
Summary: A one-step water-based recycling process is proposed to recycle and regenerate graphite anode materials from spent lithium-ion batteries (LIBs). The regenerated graphite with expanded interlayer spacing and oxygen-containing groups exhibits excellent performance in graphite dual-ion batteries (GDIBs). This waste-to-resource strategy provides a low-cost and sustainable recycling pathway for spent LIBs and enables the sustainable manufacturing of GDIBs.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Zhenhua Wu, Xiaoli Zhu, Anjin Hong, Guanghui He, Zheng Wang, Qingyan Xu, Zhiyu Hu, Xiaobing Wu, Yuezhou Wang, Qiufang Chen, Xilin Zhao, Li Li, Xianming Deng
Summary: Inspired by the structural insights from the analysis of lefamulin's cocrystal structure with S. aureus ribosomes, a series of novel pleuromutilin derivatives were designed and synthesized. The study revealed that derivatives with urea in the meta position of phenylene sulfide showed optimal antibacterial activities. Among them, 21h exhibited the most potent activity against MRSA and clinical AMR Gram-positive bacteria, with low resistance frequency and prolonged Post-Antibiotic Effect. It also showed promising antibacterial activity in vivo, making it a potential lead for new antibiotics against Gram-positive pathogens, especially for AMR bacteria.
BIOORGANIC CHEMISTRY
(2023)
