Transient receptor potential channel modulators as pharmacological treatments for lower urinary tract symptoms (LUTS): myth or reality?

Neurotoxin Treatments for Urinary Incontinence in Subjects With Spinal Cord Injury or Multiple Sclerosis: A Systematic Review of Effectiveness and Adverse Effects

(2016) Roderick MacDonald et al.   JOURNAL OF SPINAL CORD MEDICINE

Intravesical TRPV4 blockade reduces repeated variate stress-induced bladder dysfunction by increasing bladder capacity and decreasing voiding frequency in male rats

(2014) Liana Merrill et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Emulsified Isoflurane Enhances Thermal Transient Receptor Potential Vanilloid-1 Channel Activation–mediated Sensory/Nociceptive Blockade by QX-314

(2014) Cheng Zhou et al.   ANESTHESIOLOGY

TRPA1 mediates bladder hyperalgesia in a mouse model of cystitis

(2014) Jennifer J. DeBerry et al.   PAIN

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

(2014) Victor Meseguer et al.   Nature Communications

Nociceptor-selective Peripheral Nerve Block Induces Delayed Mechanical Hypersensitivity and Neurotoxicity in Rats

(2013) Christopher M. Peters et al.   ANESTHESIOLOGY

Targeting TRP channels for pain relief

(2013) Jill-Desiree Brederson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Co-Cultures Provide a New Tool to Probe Communication Between Adult Sensory Neurons and Urothelium

(2013) Lauren M. O'Mullane et al.   JOURNAL OF UROLOGY

The passive and active contractile properties of the neurogenic, underactive bladder

(2012) John S. Young et al.   BJU INTERNATIONAL

Advances in modulating thermosensory TRP channels

(2012) Antonio Ferrer-Montiel et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Pharmacological Blockade of the Cold Receptor TRPM8 Attenuates Autonomic and Behavioral Cold Defenses and Decreases Deep Body Temperature

(2012) M. C. Almeida et al.   JOURNAL OF NEUROSCIENCE

JTS-653 Blocks Afferent Nerve Firing and Attenuates Bladder Overactivity Without Affecting Normal Voiding Function

(2012) Yoshihiro Kitagawa et al.   JOURNAL OF UROLOGY

Functional roles of transient receptor potential melastatin 8 (TRPM8) channels in the cold stress-induced detrusor overactivity pathways in conscious rats

(2012) Zhang Lei et al.   NEUROUROLOGY AND URODYNAMICS

An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

(2012) Kevin S. Thorneloe et al.   Science Translational Medicine

Effects of Combination Treatment of Intravesical Resiniferatoxin Instillation and Hydrodistention in Patients with Refractory Painful Bladder Syndrome/Interstitial Cystitis: A Pilot Study

(2012) Byeong Kuk Ham et al.   International Neurourology Journal

Function and expression pattern of TRPM8 in bladder afferent neurons associated with bladder outlet obstruction in rats

(2011) Tokumasa Hayashi et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Rat detrusor overactivity induced by chronic spinalization can be abolished by a transient receptor potential vanilloid 1 (TRPV1) antagonist

(2011) André Santos-Silva et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

An investigation of the safety and pharmacokinetics of the novel TRPV1 antagonist XEN-D0501 in healthy subjects

(2011) Patrick Round et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells

(2011) D. J. Cavanaugh et al.   JOURNAL OF NEUROSCIENCE

The Mechanoreceptor TRPV4 is Localized in Adherence Junctions of the Human Bladder Urothelium: A Morphological Study

(2011) Dick A.W. Janssen et al.   JOURNAL OF UROLOGY

Transient receptor potential channels as therapeutic targets

(2011) Magdalene M. Moran et al.   NATURE REVIEWS DRUG DISCOVERY

Effects of TRPV4 cation channel activation on the primary bladder afferent activities of the rat

(2011) Naoki Aizawa et al.   NEUROUROLOGY AND URODYNAMICS

Functional TRPV4 channels and an absence of capsaicin-evoked currents in freshly-isolated, guinea-pig urothelial cells

(2010) Xiaoping Xu et al.   Channels

TRPA1 Receptor Induced Relaxation of the Human Urethra Involves TRPV1 and Cannabinoid Receptor Mediated Signals, and Cyclooxygenase Activation

(2010) Philipp Weinhold et al.   JOURNAL OF UROLOGY

Bladder Afferent Signaling: Recent Findings

(2010) Anthony Kanai et al.   JOURNAL OF UROLOGY

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

(2010) W. Everaerts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coapplication of Lidocaine and the Permanently Charged Sodium Channel Blocker QX-314 Produces a Long-lasting Nociceptive Blockade in Rodents

(2009) Alexander M. Binshtok et al.   ANESTHESIOLOGY

The TRPV4 Cation Channel Mediates Stretch-evoked Ca2+Influx and ATP Release in Primary Urothelial Cell Cultures

(2009) Tsutomu Mochizuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Transient Receptor Potential Vanilloid 1 is Expressed in Human Urothelial Cells

(2009) Ana Charrua et al.   JOURNAL OF UROLOGY

Selective Pharmacological Blockade of the TRPV1 Receptor Suppresses Sensory Reflexes of the Rodent Bladder

(2009) Joseph S. Cefalu et al.   JOURNAL OF UROLOGY

Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C

(2009) Guida Landouré et al.   NATURE GENETICS

Where is TRPV1 expressed in the bladder, do we see the real channel?

(2009) Wouter Everaerts et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The vanilloid transient receptor potential channel TRPV4: From structure to disease

(2009) Wouter Everaerts et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

The concept of neurogenic inflammation

(2008) Pierangelo Geppetti et al.   BJU INTERNATIONAL

Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks

(2008) Gilbert Y. Wong et al.   BRAIN RESEARCH REVIEWS

Differential Localizations of the Transient Receptor Potential Channels TRPV4 and TRPV1 in the Mouse Urinary Bladder

(2008) Takahiro Yamada et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I

(2008) K. S. Thorneloe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Systemic Activation of the Transient Receptor Potential Vanilloid Subtype 4 Channel Causes Endothelial Failure and Circulatory Collapse: Part 2

(2008) R. N. Willette et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

GRC-6211, a New Oral Specific TRPV1 Antagonist, Decreases Bladder Overactivity and Noxious Bladder Input in Cystitis Animal Models

(2008) Ana Charrua et al.   JOURNAL OF UROLOGY

Lack of TRPV1 inhibits cystitis-induced increased mechanical sensitivity in mice

(2008) Zun-Yi Wang et al.   PAIN

Effect of Menthol on Detrusor Smooth-Muscle Contraction and the Micturition Reflex in Rats

(2008) Yoshiko Nomoto et al.   UROLOGY

Transient Receptor Potential Vanilloid Type 2 (TRPV2) Expression in Normal Urothelium and in Urothelial Carcinoma of Human Bladder: Correlation with the Pathologic Stage

(2007) Sara Caprodossi et al.   EUROPEAN UROLOGY

Distribution and Function of the Hydrogen Sulfide–Sensitive TRPA1 Ion Channel in Rat Urinary Bladder

(2007) Tomi Streng et al.   EUROPEAN UROLOGY

On the origin of bladder sensing: Tr(i)ps in urology

(2007) Wouter Everaerts et al.   NEUROUROLOGY AND URODYNAMICS