Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits

CRP-guided Antibiotic Treatment in acute exacerbations of COPD admitted to Hospital

(2019) H. J. Prins et al.   EUROPEAN RESPIRATORY JOURNAL

Neural respiratory drive predicts long-term outcome following admission for exacerbation of COPD: a post hoc analysis

(2019) Maxime Patout et al.   THORAX

Eosinophil-guided corticosteroid therapy in patients admitted to hospital with COPD exacerbation (CORTICO-COP): a multicentre, randomised, controlled, open-label, non-inferiority trial

(2019) Pradeesh Sivapalan et al.   Lancet Respiratory Medicine

C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations

(2019) Christopher C. Butler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exhaled Breath Profiles Before, During and After Exacerbation of COPD: A Prospective Follow-Up Study

(2019) P. van Velzen et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Exacerbations of Chronic Obstructive Pulmonary Disease and Cardiac Events. A Post Hoc Cohort Analysis from the SUMMIT Randomized Clinical Trial

(2018) Ken M. Kunisaki et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Intensified Therapy with Inhaled Corticosteroids and Long-Acting β2-Agonists at the Onset of Upper Respiratory Tract Infection to Prevent Chronic Obstructive Pulmonary Disease Exacerbations. A Multicenter, Randomized, Double-Blind, Placebo-controlled Trial

(2018) Daiana Stolz et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Collagen degradation and formation are elevated in exacerbated COPD compared to stable disease

(2018) Desiree M. Schumann et al.   CHEST

Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease

(2018) Jeong H. Yun et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Exacerbation induces a microbiota shift in sputa of COPD patients

(2018) Eric Jubinville et al.   PLoS One

Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations

(2018) David Mayhew et al.   THORAX

Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations

(2018) Aran Singanayagam et al.   Nature Communications

Exacerbation heterogeneity in COPD: subgroup analyses from the FLAME study

(2018) Claus Vogelmeier et al.   International Journal of Chronic Obstructive Pulmonary Disease

The lung tissue microbiota of mild and moderate chronic obstructive pulmonary disease

(2018) Alexa A. Pragman et al.   Microbiome

WHAT IS A COPD EXACERBATION? CURRENT DEFINITIONS, PITFALLS, CHALLENGES AND OPPORTUNITIES FOR IMPROVEMENT

(2018) Victor Kim et al.   EUROPEAN RESPIRATORY JOURNAL

Blood eosinophils in COPD and the future risk of pneumonia

(2018) Pierre Ernst   EUROPEAN RESPIRATORY JOURNAL

Cardiac Troponin I and Cardiovascular Risk in Patients With Chronic Obstructive Pulmonary Disease

(2018) Philip D. Adamson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

What is the impact of GOLD 2017 recommendations in primary care? – a descriptive study of patient classifications, treatment burden and costs

(2018) Alicia Gayle et al.   International Journal of Chronic Obstructive Pulmonary Disease

Multi-level differential network analysis of COPD exacerbations

(2017) Guillaume Noell et al.   EUROPEAN RESPIRATORY JOURNAL

Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort

(2017) Viktoriya L. Kim et al.   EUROPEAN RESPIRATORY JOURNAL

Prevention of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline

(2017) Jadwiga A. Wedzicha et al.   EUROPEAN RESPIRATORY JOURNAL

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary

(2017) Claus F. Vogelmeier et al.   EUROPEAN RESPIRATORY JOURNAL

COPD-X Australian and New Zealand guidelines for the diagnosis and management of chronic obstructive pulmonary disease: 2017 update

(2017) Ian A Yang et al.   MEDICAL JOURNAL OF AUSTRALIA

Sputum microbiome temporal variability and dysbiosis in chronic obstructive pulmonary disease exacerbations: an analysis of the COPDMAP study

(2017) Zhang Wang et al.   THORAX

A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD

(2017) Tom M A Wilkinson et al.   THORAX

Seasonal influenza vaccination in patients with COPD: a systematic literature review

(2017) Rafik Bekkat-Berkani et al.   BMC Pulmonary Medicine

A multi-center randomized, controlled, open-label trial evaluating the effects of eosinophil-guided corticosteroid-sparing therapy in hospitalised patients with COPD exacerbations – The CORTICO steroid reduction in COPD (CORTICO-COP) study protocol

(2017) Pradeesh Sivapalan et al.   BMC Pulmonary Medicine

Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort

(2017) Annette T Hastie et al.   Lancet Respiratory Medicine

Routine molecular point-of-care testing for respiratory viruses in adults presenting to hospital with acute respiratory illness (ResPOC): a pragmatic, open-label, randomised controlled trial

(2017) Nathan J Brendish et al.   Lancet Respiratory Medicine

Blood Eosinophils and Exacerbations in Chronic Obstructive Pulmonary Disease. The Copenhagen General Population Study

(2016) Signe Vedel-Krogh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Blood Eosinophils and Outcomes in Severe Hospitalized Exacerbations of COPD

(2016) Mona Bafadhel et al.   CHEST

Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD

(2016) Joseph Footitt et al.   CHEST

Treatable traits: toward precision medicine of chronic airway diseases

(2016) Alvar Agusti et al.   EUROPEAN RESPIRATORY JOURNAL

Different pattern of viral infections and clinical outcomes in patient with acute exacerbation of chronic obstructive pulmonary disease and chronic obstructive pulmonary disease with pneumonia

(2016) Ho-Cheol Kim et al.   JOURNAL OF MEDICAL VIROLOGY

Blood eosinophil count and exacerbations in severe chronic obstructive pulmonary disease after withdrawal of inhaled corticosteroids: a post-hoc analysis of the WISDOM trial

(2016) Henrik Watz et al.   Lancet Respiratory Medicine

Risk of death and readmission of hospital-admitted COPD exacerbations: European COPD Audit

(2015) Sylvia Hartl et al.   EUROPEAN RESPIRATORY JOURNAL

Lower respiratory tract infection caused by respiratory syncytial virus: current management and new therapeutics

(2015) Natalie I Mazur et al.   Lancet Respiratory Medicine

Blood eosinophil guided prednisolone therapy for exacerbations of COPD: a further analysis

(2014) M. Bafadhel et al.   EUROPEAN RESPIRATORY JOURNAL

Human rhinovirus infection during naturally occurring COPD exacerbations

(2014) S. N. George et al.   EUROPEAN RESPIRATORY JOURNAL

Eosinophilic inflammation in COPD: prevalence and clinical characteristics: Table 1–

(2014) Dave Singh et al.   EUROPEAN RESPIRATORY JOURNAL

Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children

(2014) Tom Jefferson et al.   Sao Paulo Medical Journal

Outgrowth of the Bacterial Airway Microbiome after Rhinovirus Exacerbation of Chronic Obstructive Pulmonary Disease

(2013) Philip L. Molyneaux et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Detection and severity grading of COPD exacerbations using the exacerbations of chronic pulmonary disease tool (EXACT)

(2013) A. J. Mackay et al.   EUROPEAN RESPIRATORY JOURNAL

Exacerbation of respiratory symptoms in COPD patients may not be exacerbations of COPD

(2013) Bianca Beghé et al.   EUROPEAN RESPIRATORY JOURNAL

Inflammatory Biomarkers and Exacerbations in Chronic Obstructive Pulmonary Disease

(2013) Mette Thomsen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Blood Eosinophils to Direct Corticosteroid Treatment of Exacerbations of Chronic Obstructive Pulmonary Disease

(2012) Mona Bafadhel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rhinovirus Infection Induces Degradation of Antimicrobial Peptides and Secondary Bacterial Infection in Chronic Obstructive Pulmonary Disease

(2012) Patrick Mallia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Lung Tissue Microbiome in Chronic Obstructive Pulmonary Disease

(2012) Marc A. Sze et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary Arterial Enlargement and Acute Exacerbations of COPD

(2012) J. Michael Wells et al.   NEW ENGLAND JOURNAL OF MEDICINE

The DECAF Score: predicting hospital mortality in exacerbations of chronic obstructive pulmonary disease

(2012) John Steer et al.   THORAX

Acute Exacerbations of Chronic Obstructive Pulmonary Disease

(2011) Mona Bafadhel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Biochemical markers of cardiac dysfunction predict mortality in acute exacerbations of COPD

(2011) C. L. Chang et al.   THORAX

Neural respiratory drive as a physiological biomarker to monitor change during acute exacerbations of COPD

(2011) P. B. Murphy et al.   THORAX

Standardizing Measurement of Chronic Obstructive Pulmonary Disease Exacerbations

(2010) Nancy K. Leidy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The impact of using different symptom-based exacerbation algorithms in patients with COPD

(2010) J. C. A. Trappenburg et al.   EUROPEAN RESPIRATORY JOURNAL

Susceptibility to Exacerbation in Chronic Obstructive Pulmonary Disease

(2010) John R. Hurst et al.   NEW ENGLAND JOURNAL OF MEDICINE

Disordered Microbial Communities in Asthmatic Airways

(2010) Markus Hilty et al.   PLoS One

The Potential Value of Biomarkers in Diagnosis and Staging of COPD and Exacerbations

(2010) Anant Patel et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Serum IP-10 as a Biomarker of Human Rhinovirus Infection at Exacerbation of COPD

(2009) Jennifer K. Quint et al.   CHEST

Increased Risk of Myocardial Infarction and Stroke Following Exacerbation of COPD

(2009) Gavin C. Donaldson et al.   CHEST

Negative impacts of unreported COPD exacerbations on health-related quality of life at 1 year

(2009) W. Xu et al.   EUROPEAN RESPIRATORY JOURNAL

Viral Loads and Duration of Viral Shedding in Adult Patients Hospitalized with Influenza

(2009) Nelson Lee et al.   JOURNAL OF INFECTIOUS DISEASES

Reduced risk of next exacerbation and mortality associated with antibiotic use in COPD

(2008) B. M. Roede et al.   EUROPEAN RESPIRATORY JOURNAL

Inflammatory Profile of New Bacterial Strain Exacerbations of Chronic Obstructive Pulmonary Disease

(2007) Sanjay Sethi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE