Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 36, Issue 12, Pages 2044-2050Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X16674488
Keywords
Brain ischemia; endoplasmic reticulum; myocardial ischemia; stroke; unfolded protein response
Categories
Funding
- National Institutes of Health R01 grant [NS099590, HL095552, NS081299, NS097554]
- American Heart Association [12SDG11950003, 16GRNT30270003]
- National Institutes of Health R21 grant [NS057375]
- National Institutes of Health R03 grant [NS078590]
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Folding and processing newly synthesized proteins are vital functions of the endoplasmic reticulum that are sensitive to a variety of stress conditions. The unfolded protein response is activated to restore endoplasmic reticulum function impaired by stress. While we know that brain ischemia impairs endoplasmic reticulum function, the role of unfolded protein response activation in post-ischemic recovery of neurologic function is only beginning to emerge. Here, we summarize what is known about endoplasmic reticulum stress and unfolded protein response in brain ischemia and discuss recent findings from myocardial ischemia studies that could help to advance research on endoplasmic reticulum stress and unfolded protein response in brain ischemia.
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