Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 240, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2020.118545
Keywords
Fluorescent probes; Hypochlorous acid/hypochlorite; Living cell imaging; Near-infrared probes; Endogenous detection
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Funding
- National Key Research and Development Program of China [2019YFC1606400, 2019YFC1606404]
- Nanjing Normal University-Zhejiang Kingsun Eco-pack Union Laboratory [S11420B41903]
- research start-up funding for Nanjing Normal University introduced talents [184080H202B231]
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Hypochlorous acid/hypochlorite (HOCl/OCl-), as one of the most important reactive oxygen species (ROS), plays an important role in various physiological and pathological processes. Nonproperly located or abnormal concentration of OCl-, however, is associated with many diseases. Thus, developing the fluorescent probe for detecting OCl- is of great significance. To this end, in last decade, many fluorescent probes have been developed and applied for detecting HOCl/OCl- in vitro and in vivo. Despite a great progress has achieved, the development and application of near-infrared fluorescent HOCl/OCl- probe still have some challenges. For example, highly specific and sensitive NIR fluorescent HOCl/OCl- probes applied in endogenous OCl- detection and subcellular organelle bioimaging. In this review, we summarized the representative cases of HOCl/OCl- probes with properties that mentioned above. The discussion contains design strategies, detection mechanisms, as well as applications in bioimaging. (c) 2020 Elsevier B.V. All rights reserved.
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