Review
Plant Sciences
Miao Xu, Qi Zhang, Xiuyun Lin, Yuqing Shang, Xiyan Cui, Liquan Guo, Yuanrui Huang, Ming Wu, Kai Song
Summary: This research provides a detailed explanation of the hazardous and advantageous impacts of common metal oxide nanomaterials, such as iron oxide, copper oxide, and zinc oxide, on the life cycle of rice. The study analyzes various aspects including nanoparticle transport patterns in rice, plant reactions to stress, reduction of heavy metal stress, and improvement of rice quality by metal oxide nanoparticles. It emphasizes the need for further research on the molecular mechanisms of the effects of metal oxide nanoparticles on rice and the combined use with other biological media.
Review
Pharmacology & Pharmacy
Deepa Mundekkad, William C. Cho
Summary: Research on nanoparticles, especially metal nanoparticles, in cancer therapy is gaining momentum. The versatility and biocompatibility of metal nanoparticles make them ideal for various applications in cancer therapy. They can bring about apoptotic cell death in cancer cells and mediate a special type of autophagy called mitophagy. Nanoparticles with antioxidant properties are capable of inducing mitophagy by altering the levels of reactive oxygen species and influencing signaling pathways.
Review
Pharmacology & Pharmacy
Junchao Luo, Yin Zhang, Senbo Zhu, Yu Tong, Lichen Ji, Wei Zhang, Qiong Zhang, Qing Bi
Summary: Nanoparticles show potential benefits in treating osteoarthritis by simulating antioxidant enzyme activity and catalyzing the degradation of superoxide anions, thus alleviating inflammation and promoting cartilage repair.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mohamed F. Dora, Nabil M. Taha, Mohamed A. Lebda, Aml E. Hashem, Mohamed S. Elfeky, Yasser S. El-Sayed, Soad Al Jaouni, Ali H. El-Far
Summary: The study revealed that IONPs induced oxidative damage in the brains of rats, while quercetin supplementation could effectively protect the brain from oxidative injuries in a dose-dependent manner. It is recommended to supplement quercetin during IONP therapy to reduce potential health hazards.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Yuanyuan Xu, Yu Zhao, Shanji Liu, Sidi Lv, Ling Chen, Wanzhen Wang, Yueying Feng, Fen Fu, Hengyi Xu
Summary: This study found that zinc oxide nanoparticles have toxic effects on the ovaries of female mice, which are attributed to oxidative stress, endoplasmic reticulum stress, and activation of apoptosis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Engineering, Environmental
Xingyao Pei, Haiyang Jiang, Cun Li, Daowen Li, Shusheng Tang
Summary: We discovered a novel mechanism of liver damage induced by ZnO NPs, demonstrating the activation of the pyroptosis pathway and clarifying the protective role of antioxidants against this damage.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Katarina Siposova, Veronika Huntosova, Ivana Garcarova, Yuliia Shlapa, Illia Timashkov, Anatolii Belous, Andrey Musatov
Summary: Oxidative stress is associated with amyloid-related diseases, and understanding the interplay between them is crucial for aging and age-related neurodegenerative diseases. Cerium dioxide nanoparticles show potential in studying oxidative stress and amyloid-related diseases, as their antioxidative effects and bioactivity depend on the size and valence of the nanoparticles.
Article
Biochemistry & Molecular Biology
Suzan Attia Mawed, Carlotta Marini, Mahmoud Alagawany, Mayada R. Farag, Rasha M. Reda, Mohamed T. El-Saadony, Walaa M. Elhady, Gian E. Magi, Alessandro Di Cerbo, Wafaa G. El-Nagar
Summary: This study elucidated the ultrastructure changes in the ovary in response to exposure to zinc oxide nanoparticles (ZnO-NPs) and explored the role of autophagy and apoptosis in the fertility of female zebrafish. The results showed that ZnO-NPs induced cytotoxicity, oxidative stress, and necroptosis, leading to a reduction in the fecundity of female zebrafish.
Article
Biochemistry & Molecular Biology
Ibrahim M. M. Alhazza, Iftekhar Hassan, Hossam Ebaid, Jameel Al-Tamimi, Zafrul Hasan
Summary: This study investigates the therapeutic potential of zinc oxide nanoparticles (ZnO NPs) against potassium bromate (PB)-induced nephrotoxicity in Swiss albino rats, and the results demonstrate the significant ameliorative efficacy of ZnO NPs in treating PB-induced kidney toxicity.
Article
Plant Sciences
Xiaoxiao Liu, Di Gong, Qingbo Ke, Lina Yin, Shiwen Wang, Tianpeng Gao
Summary: A meta-analysis of 86 studies has shown that nitric oxide (NO) can significantly improve plant biomass, alleviate oxidative damage, and increase the content of Ca, Fe, and Mg in heavy metal-stressed plants. The optimal concentration of SNP (an NO donor) for hydroponic culture is in the range of 75-150 μM. These findings provide valuable insights for the future application of NO as a plant growth regulator for enhancing heavy metal stress tolerance in agriculture and breeding.
Article
Toxicology
Lin Wu, Wen Wen, Xiaofeng Wang, Danhua Huang, Jin Cao, Xueyong Qi, Song Shen
Summary: The study found that ultrasmall Fe3O4 nanoparticles have high toxicity, especially on the heart. The toxicity is related to both the iron element and particle size, providing new insights into the toxicology of ultrasmall Fe3O4 nanoparticles.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Environmental Sciences
Rajesh Koley, Debojyoti Mishra, Naba Kumar Mondal
Summary: In this study, magnesium oxide nanoparticles (MgO NPs) synthesized through a green route were evaluated for their efficacy in reducing arsenic (As) accumulation and phytotoxicity in rice plants. The results showed that the application of MgO NPs significantly reduced As accumulation in the roots and shoots of rice seedlings, and improved their growth and antioxidant defense system activity. These findings suggest the potential use of MgO NPs for mitigating As contamination and improving rice yield.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Mariana Vassal, Sandra Rebelo, Maria de Lourdes Pereira
Summary: Metal oxide nanoparticles have versatile properties that make them valuable in healthcare, but recent studies suggest they may have negative effects on male fertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Somu Yadav, Pawan Kumar Maurya
Summary: Metal oxide nanoparticles possess unique properties such as catalyzing the neutralization of reactive oxygen species and have been increasingly utilized in diagnostics and therapeutics for age-related disorders. These nanoparticles play a critical role in reducing oxidative stress and inflammation, thus contributing to the prevention and treatment of aging-related diseases.
Article
Environmental Sciences
Xueying Du, Weishang Zhou, Weixia Zhang, Shuge Sun, Yu Han, Yu Tang, Wei Shi, Guangxu Liu
Summary: The study found that metal oxide nanoparticles have a significant inhibitory effect on the motility of marine microalgae, possibly through restricting the energy supply needed for swimming and inducing oxidative stress.
ENVIRONMENTAL POLLUTION
(2021)
Review
Crystallography
Lili Wang, Yang Liu, Guoli Chen, Mengyuan Zhang, Xiaodong Yang, Rui Chen, Yan Cheng
Summary: Environmental pollution and diseases have a significant impact on human health. Photocatalytic nanomaterials have been widely used for pollution degradation, but their biomedical applications have been less explored. Among these materials, bismuth oxychloride (BiOCl) stands out for its excellent photocatalytic performance and stability. BiOCl-based nanomaterials can not only detect, but also degrade various environmental pollutants, such as volatile organic compounds, antibiotics and their derivatives, heavy metal ions, pesticides, and microorganisms. Moreover, they have been used in theranostic platforms for CT and photoacoustic imaging, as well as photodynamic and photothermal performances. However, there is still a knowledge gap in understanding the relationship between BiOCl-based nanomaterials and human health.
Article
Oncology
Jia-hong Wang, Xiao-shan Li, Hong-sheng Tang, Run-ya Fang, Jing-jing Song, Yan-lin Feng, Tian-pei Guan, Qiang Ruan, Jin Wang, Shu-Zhong Cui
Summary: The study found that the VETC pattern can serve as a predictive factor for whether hepatocellular carcinoma patients can benefit from adjuvant TACE therapy. Patients with the VETC pattern showed significant survival benefits from adjuvant TACE therapy, while those without the VETC pattern did not derive any benefits. Additionally, the combination of the VETC pattern with high-risk factors such as vascular invasion, larger tumor size, or multiple tumors further improved the efficacy of adjuvant TACE therapy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Chemistry, Physical
Yanlin Feng, Jianlin Wang, Xin Ning, Aiyun Li, Qing You, Wanzhen Su, Deping Wang, Jianyun Shi, Lan Zhou, Fangfang Cao, Xiaoyuan Chen, Jimin Cao
Summary: A new nanostructure has been developed to selectively and persistently block energy generation of triple-negative breast cancer cells, inducing apoptosis. The therapeutic effects have been demonstrated in vitro and in vivo, providing a new approach for metabolic interventions.
Review
Anatomy & Morphology
Gyuhyung Jin, Yun Chang, Jackson Duke Harris, Xiaoping Bao
Summary: The past decade has seen significant advancements in cancer immunotherapy, particularly in the use of engineered T cells for treating advanced leukemias and lymphomas. However, challenges still exist in terms of scale, cost, and quality control of engineered immune cells. The emergence of human pluripotent stem cells (hPSCs) has revolutionized immunotherapy by providing a scalable and readily available source of immune cells for research and clinical interventions. This review explores the different types of immune cells that have been derived from hPSCs and their potential applications in translational immunotherapy.
CELLS TISSUES ORGANS
(2023)
Article
Biophysics
Hongxiang Liu, Miao Ding, Hao Wang, Yining Chen, Yang Liu, Liqi Wei, Xingyu Cui, Yu Han, Biao Zhang, Tianshu Zou, Yuan Zhang, Haiyan Li, Rui Chen, Xin Liu, Yan Cheng
Summary: Silver nanoparticles modified camelina oil bodies with human fibroblast growth factor 2 were designed for the treatment of bacterial infection wounds. The results showed that this material had both antibacterial and wound healing effects, with good biocompatibility. Therefore, it has potential for application in the repair of bacterial infection wounds.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Yanlin Feng, Xin Ning, Jianlin Wang, Zhaoyang Wen, Fangfang Cao, Qing You, Jianhua Zou, Xin Zhou, Teng Sun, Jimin Cao, Xiaoyuan Chen
Summary: Photoimmunotherapy is a novel targeted therapeutic strategy for highly malignant triple-negative breast cancer. However, its therapeutic effect is restricted by limited tissue penetration of light and complex immunosuppressive microenvironment. A new mace-like plasmonic Au-Pd heterostructures have been developed to enhance the outcomes of photoimmunotherapy. These structures exhibit strong photothermal and photodynamic effects, triggering immunogenic cell death and stimulating immune response. This study integrates nanotopology and plasmonic performance for the treatment of TNBC through immunotherapy.
Article
Pharmacology & Pharmacy
Yanlin Feng, Yumei Xu, Zhaoyang Wen, Xin Ning, Jianlin Wang, Deping Wang, Jimin Cao, Xin Zhou
Summary: This study designed cerium oxide (CeO2) encapsulated gold nanorods (CEG) for near-infrared photoimmunotherapy, which can generate hot electrons and reactive oxygen species to trigger immunogenic cell death and activate the immune response. Combined with PD-1 antibody, it enhances cytotoxic T lymphocyte infiltration, reverses the immunosuppressive microenvironment, and thoroughly activates the immune response. This platform demonstrates the superiority of combination therapy of photoimmunotherapy and PD-1 blockade in TNBC therapy.
Article
Nanoscience & Nanotechnology
Yuan Zhang, Ruinan Wang, Huaiyu Fan, Manru Wang, Hongxiang Liu, Yuqi Wang, Xingyu Cui, Enze Wang, Biao Zhang, Hongtao Gao, Xin Liu, Haiyan Li, Yan Cheng
Summary: A novel nanobiomaterial, CDs-CLD-hFGF2, was synthesized by decorating camelina-derived carbon dots (CDs) on hFGF2-linked camelina lipid droplets (CLD-hFGF2). The CDs-CLD-hFGF2 exhibited peroxidase activity and effective reactive oxygen species radical scavenging activity, while promoting the proliferation of NIH/3T3 cells under oxidative stress in vitro. In an acute wound model, wound healing after CDs-CLD-hFGF2 treatment reached nearly 92% on the 10th day, higher than the 82% for CLD-hFGF2. The treatment also showed significant anti-inflammatory effects, as indicated by the downregulation of pro-inflammatory factors and upregulation of anti-inflammatory factors.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Yining Chen, Yunan Yang, Xinai He, Xin Liu, Pengcheng Yu, Runru Liu, Liqi Wei, Biao Zhang, Tianshu Zou, Hongxiang Liu, Yuanqiang Li, Rui Chen, Yan Cheng
Summary: This study developed a semiconductor nanomaterial that can eliminate tumors through photoactivated immunotherapy. The nanomaterial, with a narrow band gap, allows for photothermal and photodynamic amplified immunotherapy by near-infrared light activation, and it can also serve as a nanocarrier for controlled drug release.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Yining Chen, Tianshu Zou, Gaoying Xin, Xin Liu, Yunan Yang, Liqi Wei, Biao Zhang, Pengcheng Yu, Yiping Ren, Yanlin Feng, Rui Chen, Fangfang Cao, Xiaoyuan Chen, Yan Cheng
Summary: This study presents a novel approach for tumor treatment by developing BiOCl-Au-Ag2S Z-scheme heterostructure nanoparticles loaded with tirapazamine (TPZ). These nanoparticles exhibit efficient electron-hole separation under ultrasound irradiation and have a high redox potential. The generated holes react with water to produce hydroxyl radicals, while the electrons autonomously activate TPZ, leading to synergistic sonodynamic and hypoxia-activated prodrugs therapy without the need for oxygen.
ADVANCED MATERIALS
(2023)
Article
Engineering, Environmental
Hongxiang Liu, Tianshu Zou, Xingyu Cui, Miao Ding, Biao Zhang, Xiaodong Yang, Yu Han, Shuwei Nie, Yuan Zhang, Enze Wang, Lili Wang, Yan Cheng, Xin Liu, Rui Chen
Summary: Solar-driven interfacial water evaporation offers a solution for clean freshwater generation. By utilizing oil body (OB)-polypyrrole (PPy) as an absorber, higher water evaporation rate and freshwater collection capabilities can be achieved. The OB-PPy absorber exhibits excellent photothermal performance and water transporting ability. It also shows stability and reusability, with the ability to produce freshwater from humid air.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Oncology
Jianyun Shi, Wenjing Li, Zhenhua Jia, Ying Peng, Jiayi Hou, Ning Li, Ruijuan Meng, Wei Fu, Yanlin Feng, Lifei Wu, Lan Zhou, Deping Wang, Jing Shen, Jiasong Chang, Yanqiang Wang, Jimin Cao
Summary: This study demonstrates that SYT1 is downregulated in colorectal cancer (CRC) and overexpression of SYT1 suppresses CRC cell migration, invasion, and metastasis by inhibiting the ERK/MAPK signaling-mediated pseudopodial formation. These findings provide new insights into CRC development and suggest that SYT1 may have the potential to be a therapeutic target for CRC.
Article
Engineering, Biomedical
Yun Chang, Gyuhyung Jin, Weichuan Luo, Qian Luo, Juhyung Jung, Sydney N. Hummel, Sandra Torregrosa-Allen, Bennett D. Elzey, Philip S. Low, Xiaojun Lance Lian, Xiaoping Bao
Summary: Adoptive CAR-engineered NK cells have potential for cancer treatment, but limited immunological memory and donor cell availability hinder their applications. We evaluated different CAR constructs to enhance NK cell proliferation and anti-tumor cytotoxicity. We genetically engineered hPSCs with optimized CARs and differentiated them into dual CAR-NK cells. The memory-like hPSC-NK cells showed enhanced anti-tumor activity through antigen-dependent activation of signaling pathways. Our modular hPSC CAR-NK engineering platform is a realistic strategy for off-the-shelf CAR-NK cells with immunological memory-like phenotype for targeted immunotherapy.
BIOACTIVE MATERIALS
(2023)
Article
Forestry
Weiwei Wang, Kai Chen, Ningning Chen, Jinwen Gao, Wenyan Zhang, Jue Gong, Shaofei Tong, Yang Chen, Yiling Li, Yanlin Feng, Yuanzhong Jiang, Tao Ma
Summary: In this study, the chromatin regulatory landscapes of poplar under different environmental stresses were investigated using ATAC-seq and RNA-seq data. It was found that the accessibility of chromatin is closely related to the expression level of genes. However, while gene expression showed treatment-specific response patterns, changes in chromatin accessibility exhibited high similarities under these treatments. Furthermore, it was proposed and experimentally validated that a homologous gene copy plays a role in mediating the crosstalk between different signaling pathways, and circadian clock-related transcription factors are crucial in the response of poplar to these treatments.
Article
Chemistry, Physical
Yanlin Feng, Jianlin Wang, Xin Ning, Aiyun Li, Qing You, Wanzhen Su, Deping Wang, Jianyun Shi, Lan Zhou, Fangfang Cao, Xiaoyuan Chen, Jimin Cao
Summary: We developed a stable pyroelectric BaTiO3@Au core-shell nanostructure that can selectively block energy generation of tumor cells, providing a promising therapeutic approach for triple-negative breast cancer.
