Combined nucleus pulposus augmentation and annulus fibrosus repair prevents acute intervertebral disc degeneration after discectomy

Composite biomaterial repair strategy to restore biomechanical function and reduce herniation risk in an ex vivo large animal model of intervertebral disc herniation with varying injury severity

(2019) Warren W. Hom et al.   PLoS One

Genipin cross-linked type II collagen/chondroitin sulfate composite hydrogel-like cell delivery system induces differentiation of adipose-derived stem cells and regenerates degenerated nucleus pulposus

(2018) Xiaopeng Zhou et al.   Acta Biomaterialia

In Vivo Annular Repair using High-Density Collagen Gel Seeded with Annulus Fibrosus Cells

(2018) Yu Moriguchi et al.   Acta Biomaterialia

Endplate changes after lumbar discectomy with and without implantation of an annular closure device

(2018) Martin Barth et al.   ACTA NEUROCHIRURGICA

Biologic Annulus Fibrosus Repair: A Review of Preclinical In Vivo Investigations

(2018) Stephen R. Sloan et al.   TISSUE ENGINEERING PART B-REVIEWS

Biologic canine and human intervertebral disc repair by notochordal cell-derived matrix: from bench towards bedside

(2018) Frances C. Bach et al.   Oncotarget

Biomaterials for intervertebral disc regeneration: Current status and looming challenges

(2018) Yong-Can Huang et al.   Journal of Tissue Engineering and Regenerative Medicine

Mesenchymal Stem Cell-Seeded High-Density Collagen Gel for Annular Repair: 6-Week Results From In Vivo Sheep Models

(2018) Ibrahim Hussain et al.   NEUROSURGERY

Long-term mechanical function and integration of an implanted tissue-engineered intervertebral disc

(2018) Sarah E. Gullbrand et al.   Science Translational Medicine

In vitro and biomechanical screening of polyethylene glycol and poly(trimethylene carbonate) block copolymers for annulus fibrosus repair

(2017) Rose G. Long et al.   Journal of Tissue Engineering and Regenerative Medicine

Annulus Fibrosus Repair Using High-Density Collagen Gel: An In vivo Ovine Model

(2017) Brenton Pennicooke et al.   SPINE

Reoperation Rates After Single-level Lumbar Discectomy

(2017) Patrick Heindel et al.   SPINE

Cell therapy for intervertebral disc repair: Clinical perspective

(2017) Daisuke Sakai et al.   Journal of Orthopaedic Translation

Total disc replacement using tissue-engineered intervertebral discs in the canine cervical spine

(2017) Yu Moriguchi et al.   PLoS One

Mechanical restoration and failure analyses of a hydrogel and scaffold composite strategy for annulus fibrosus repair

(2016) Rose G. Long et al.   Acta Biomaterialia

Design Requirements for Annulus Fibrosus Repair: Review of Forces, Displacements, and Material Properties of the Intervertebral Disk and a Summary of Candidate Hydrogels for Repair

(2016) Rose G. Long et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

A Review of Animal Models of Intervertebral Disc Degeneration: Pathophysiology, Regeneration, and Translation to the Clinic

(2016) Chris Daly et al.   Biomed Research International

Effect of an Annular Closure Device (Barricaid) on Same-Level Recurrent Disk Herniation and Disk Height Loss After Primary Lumbar Discectomy

(2016) Scott L. Parker et al.   Clinical Spine Surgery

Riboflavin crosslinked high-density collagen gel for the repair of annular defects in intervertebral discs: An in vivo study

(2015) Peter Grunert et al.   Acta Biomaterialia

Evaluation of an In Situ Gelable and Injectable Hydrogel Treatment to Preserve Human Disc Mechanical Function Undergoing Physiologic Cyclic Loading Followed by Hydrated Recovery

(2015) Brent L. Showalter et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-TNFα drug

(2015) Morakot Likhitpanichkul et al.   Spine Journal

Injectable, high-density collagen gels for annulus fibrosus repair: Anin vitrorat tail model

(2014) Brandon Borde et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Mesenchymal progenitor cells combined with pentosan polysulfate mediating disc regeneration at the time of microdiscectomy: a preliminary study in an ovine model

(2014) David Oehme et al.   JOURNAL OF NEUROSURGERY-SPINE

Tissue-engineered intervertebral discs: MRI results and histology in the rodent spine

(2014) Peter Grunert et al.   JOURNAL OF NEUROSURGERY-SPINE

Assessment of Intervertebral Disc Degeneration Based on Quantitative Magnetic Resonance Imaging Analysis

(2014) Peter Grunert et al.   SPINE

Effects of nucleus pulposus cell-derived acellular matrix on the differentiation of mesenchymal stem cells

(2013) Minting Yuan et al.   BIOMATERIALS

Recent advances in biological therapies for disc degeneration: tissue engineering of the annulus fibrosus, nucleus pulposus and whole intervertebral discs

(2013) Katherine D Hudson et al.   CURRENT OPINION IN BIOTECHNOLOGY

Enhancing tissue repair in annulus fibrosus defects of the intervertebral disc: analysis of a bio-integrative annulus implant in anin-vivoovine model

(2013) Aldemar Andres Hegewald et al.   Journal of Tissue Engineering and Regenerative Medicine

Adipose-derived stem cell-containing hyaluronic acid/alginate hydrogel improves vocal fold wound healing

(2013) Young-Mo Kim et al.   LARYNGOSCOPE

Preliminary Investigations on Intradiscal Pressures during Daily Activities: An In Vivo Study Using the Merino Sheep

(2013) Sandra Reitmaier et al.   PLoS One

Prospective, Multicenter, Randomized, Controlled Study of Anular Repair in Lumbar Discectomy

(2013) Alexander Bailey et al.   SPINE

Annular Repair Using High-Density Collagen Gel

(2013) Peter Grunert et al.   SPINE

BMP13 Prevents the Effects of Annular Injury in an Ovine Model

(2012) Aiqun Wei et al.   International Journal of Biological Sciences

Height and torsional stiffness are most sensitive to annular injury in large animal intervertebral discs

(2012) Arthur J. Michalek et al.   Spine Journal

Regenerating Nucleus Pulposus of the Intervertebral Disc Using Biodegradable Nanofibrous Polymer Scaffolds

(2012) Ganjun Feng et al.   TISSUE ENGINEERING PART A

Injectable thermoreversible hyaluronan-based hydrogels for nucleus pulposus cell encapsulation

(2011) Marianna Peroglio et al.   EUROPEAN SPINE JOURNAL

Time course investigation of intervertebral disc degeneration produced by needle-stab injury of the rat caudal spine

(2011) Huina Zhang et al.   JOURNAL OF NEUROSURGERY-SPINE

Intervertebral disc (IVD): Structure, degeneration, repair and regeneration

(2011) Benjamin R. Whatley et al.   Materials Science & Engineering C-Materials for Biological Applications

Tissue-engineered intervertebral discs produce new matrix, maintain disc height, and restore biomechanical function to the rodent spine

(2011) Robby D. Bowles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regeneration of the Intervertebral Disc With Nucleus Pulposus Cell-Seeded Collagen II/Hyaluronan/Chondroitin-6-Sulfate Tri-Copolymer Constructs in a Rabbit Disc Degeneration Model

(2011) Bo Huang et al.   SPINE

Asymptomatic Same-Site Recurrent Disc Herniation After Lumbar Discectomy

(2011) Richard L. Lebow et al.   SPINE

Injectable oxidized hyaluronic acid/adipic acid dihydrazide hydrogel for nucleus pulposus regeneration

(2010) Wen-Yu Su et al.   Acta Biomaterialia

Measuring the global burden of low back pain

(2010) Damian Hoy et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

The Effect of a New Anular Repair After Discectomy in Intervertebral Disc Degeneration

(2010) Chang-Jung Chiang et al.   SPINE

Gel-Like Structure of a Hexadecyl Derivative of Hyaluronic Acid for the Treatment of Osteoarthritis

(2009) Ivana Finelli et al.   MACROMOLECULAR BIOSCIENCE

RECURRENT LUMBAR DISC HERNIATION AFTER SINGLE-LEVEL LUMBAR DISCECTOMY

(2009) Giannina L. Garcés Ambrossi et al.   NEUROSURGERY

Needle Puncture Injury Affects Intervertebral Disc Mechanics and Biology in an Organ Culture Model

(2009) Casey L. Korecki et al.   SPINE

The Effect of Relative Needle Diameter in Puncture and Sham Injection Animal Models of Degeneration

(2009) Dawn M. Elliott et al.   SPINE

Nucleus Replacement With the DASCOR Disc Arthroplasty Device

(2009) Michael Ahrens et al.   SPINE

Degenerative Lumbar Disc and Facet Disease in Older Adults

(2009) Gregory E. Hicks et al.   SPINE

Small Intestinal Submucosa for Anular Defect Closure

(2009) Eric H. Ledet et al.   SPINE

Economic impact of improving outcomes of lumbar discectomy

(2009) John Sherman et al.   Spine Journal

The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain

(2008) A. J. Freemont   RHEUMATOLOGY

Age-Related Changes in the Extracellular Matrix of Nucleus Pulposus and Anulus Fibrosus of Human Intervertebral Disc

(2008) Kern Singh et al.   SPINE