Diacylglycerol kinase ζ promotes actin cytoskeleton remodeling and mechanical forces at the B cell immune synapse

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

(2018) Robert K. Abbott et al.   IMMUNITY

Profiling the origin, dynamics, and function of traction force in B cell activation

(2018) Junyi Wang et al.   Science Signaling

Micropipette force probe to quantify single-cell force generation: application to T-cell activation

(2017) Anna Sawicka et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanical Communication at the Immunological Synapse

(2017) Roshni Basu et al.   TRENDS IN CELL BIOLOGY

Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing

(2016) Roshni Basu et al.   CELL

T-lymphocyte passive deformation is controlled by unfolding of membrane surface reservoirs

(2016) Lionel Guillou et al.   MOLECULAR BIOLOGY OF THE CELL

Germinal center B cells recognize antigen through a specialized immune synapse architecture

(2016) Carla R Nowosad et al.   NATURE IMMUNOLOGY

Diacylglycerol kinase   limits the polarized recruitment of diacylglycerol-enriched organelles to the immune synapse in T cells

(2016) E. Andrada et al.   Science Signaling

Actin nucleation at the centrosome controls lymphocyte polarity

(2016) Dorian Obino et al.   Nature Communications

Dynamic monitoring of cell mechanical properties using profile microindentation

(2016) L. Guillou et al.   Scientific Reports

Diacylglycerol kinase   limits the polarized recruitment of diacylglycerol-enriched organelles to the immune synapse in T cells

(2016) E. Andrada et al.   Science Signaling

F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse

(2015) William A. Comrie et al.   JOURNAL OF CELL BIOLOGY

Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse

(2015) Anne Reversat et al.   MOLECULAR BIOLOGY OF THE CELL

Redundant and specialized roles for diacylglycerol kinases   and   in the control of T cell functions

(2015) I. Merida et al.   Science Signaling

Redundant and specialized roles for diacylglycerol kinases   and   in the control of T cell functions

(2015) I. Merida et al.   Science Signaling

B Cells use Conserved Polarity Cues to Regulate Their Antigen Processing and Presentation Functions

(2015) Maria-Isabel Yuseff et al.   Frontiers in Immunology

Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor-Transduced Human T cells in Solid Tumors

(2014) E. K. Moon et al.   CLINICAL CANCER RESEARCH

Diacylglycerol kinase   establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse

(2014) A. Chauveau et al.   Science Signaling

Cell dipole behaviour revealed by ECM sub-cellular geometry

(2014) Kalpana Mandal et al.   Nature Communications

Annular PIP 3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse

(2013) Audrey Le Floc’h et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vinculin Arrests Motile B Cells by Stabilizing Integrin Clustering at the Immune Synapse

(2013) J. Saez de Guinoa et al.   JOURNAL OF IMMUNOLOGY

B Cells Use Mechanical Energy to Discriminate Antigen Affinities

(2013) E. Natkanski et al.   SCIENCE

Diacylglycerol Kinase   Limits B Cell Antigen Receptor-Dependent Activation of ERK Signaling to Inhibit Early Antibody Responses

(2013) M. L. Wheeler et al.   Science Signaling

The   Isoform of Diacylglycerol Kinase Plays a Predominant Role in Regulatory T Cell Development and TCR-Mediated Ras Signaling

(2013) R. P. Joshi et al.   Science Signaling

Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration

(2012) Elena Rainero et al.   JOURNAL OF CELL BIOLOGY

High DGK-  and Disabled MAPK Pathways Cause Dysfunction of Human Tumor-Infiltrating CD8+ T Cells That Is Reversible by Pharmacologic Intervention

(2012) P. U. Prinz et al.   JOURNAL OF IMMUNOLOGY

Phosphatidic acid regulation of PIPKI is critical for actin cytoskeletal reorganization

(2012) Akua N. Roach et al.   JOURNAL OF LIPID RESEARCH

Diacylglycerol kinase ζ regulates RhoA activation via a kinase-independent scaffolding mechanism

(2012) Ryan Ard et al.   MOLECULAR BIOLOGY OF THE CELL

CXCL13/CXCR5 signaling enhances BCR-triggered B-cell activation by shaping cell dynamics

(2011) J. Saez de Guinoa et al.   BLOOD

Polarized Secretion of Lysosomes at the B Cell Synapse Couples Antigen Extraction to Processing and Presentation

(2011) Maria-Isabel Yuseff et al.   IMMUNITY

Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration

(2011) Violaine D. Delorme-Walker et al.   JOURNAL OF CELL BIOLOGY

Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse

(2011) Severine I. Gharbi et al.   MOLECULAR BIOLOGY OF THE CELL

A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells

(2011) Emily J Quann et al.   NATURE IMMUNOLOGY

Force Generation upon T Cell Receptor Engagement

(2011) Julien Husson et al.   PLoS One

Ca 2+ influx and protein scaffolding via TRPC3 sustain PKCβ and ERK activation in B cells

(2010) Takuro Numaga et al.   JOURNAL OF CELL SCIENCE

Diacylglycerol kinase   mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI

(2010) F. Chianale et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diacylglycerol Kinase ζ Regulates Actin Cytoskeleton Reorganization through Dissociation of Rac1 from RhoGDI

(2009) Hanan Abramovici et al.   MOLECULAR BIOLOGY OF THE CELL

Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells

(2009) Emily J Quann et al.   NATURE IMMUNOLOGY

Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis

(2009) A. Nishikimi et al.   SCIENCE

Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes

(2008) Arnauld Sergé et al.   NATURE METHODS