Synthesis of proteins by automated flow chemistry

Automated Flow Synthesis of Tumor Neoantigen Peptides for Personalized Immunotherapy

(2020) Nicholas L. Truex et al.   Scientific Reports

In-solution enrichment identifies peptide inhibitors of protein–protein interactions

(2019) Fayçal Touti et al.   Nature Chemical Biology

Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations

(2019) Vangelis Agouridas et al.   CHEMICAL REVIEWS

The renascence of continuous-flow peptide synthesis – an abridged account of solid and solution-based approaches

(2018) Christopher P. Gordon   ORGANIC & BIOMOLECULAR CHEMISTRY

An optimised approach for continuous-flow solid-phase peptide synthesis utilising a rudimentary flow reactor

(2018) Lawson Kyle Spare et al.   Reaction Chemistry & Engineering

Peptide Synthesis Utilizing Micro-flow Technology

(2018) Shinichiro Fuse et al.   Chemistry-An Asian Journal

Enhancing Protein Stability with Genetically Encoded Noncanonical Amino Acids

(2018) Jack C. Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expanding and reprogramming the genetic code

(2017) Jason W. Chin   NATURE

A fully automated flow-based approach for accelerated peptide synthesis

(2017) Alexander J Mijalis et al.   Nature Chemical Biology

FGF1 — a new weapon to control type 2 diabetes mellitus

(2017) Emanuel Gasser et al.   Nature Reviews Endocrinology

Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins

(2016) Somasekhar Bondalapati et al.   Nature Chemistry

Mutation Choice to Eliminate Buried Free Cysteines in Protein Therapeutics

(2015) Xue Xia et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Exploring the potential impact of an expanded genetic code on protein function

(2015) Han Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Total synthesis and biochemical characterization of mirror image barnase

(2015) Alexander A. Vinogradov et al.   Chemical Science

Flow-Based Enzymatic Ligation by Sortase A

(2014) Rocco L. Policarpo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid Total Synthesis of DARPin pE59 and Barnase

(2014) Surin K. Mong et al.   CHEMBIOCHEM

Rapid Flow-Based Peptide Synthesis

(2014) Mark D. Simon et al.   CHEMBIOCHEM

Editorial overview: Synthetic Biomolecules

(2014) Stephen BH Kent et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Efficient Amide Bond Formation through a Rapid and Strong Activation of Carboxylic Acids in a Microflow Reactor

(2013) Shinichiro Fuse et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sequence-Controlled Polymers

(2013) J.-F. Lutz et al.   SCIENCE

Protein Thioester Synthesis Enabled by Sortase

(2012) Jingjing J. Ling et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interrogation of MDM2 Phosphorylation in p53 Activation Using Native Chemical Ligation: The Functional Role of Ser17 Phosphorylation in MDM2 Reexamined

(2012) Changyou Zhan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Acid-Mediated Prevention of Aspartimide Formation in Solid Phase Peptide Synthesis

(2012) Tillmann Michels et al.   ORGANIC LETTERS

Peptide Coupling Reagents, More than a Letter Soup

(2011) Ayman El-Faham et al.   CHEMICAL REVIEWS

High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx

(2010) Anna Czarna et al.   CELL CYCLE

Total chemical synthesis of human proinsulin

(2010) Samuel Luisier et al.   CHEMICAL COMMUNICATIONS

Solution Structure of Proinsulin

(2010) Yanwu Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Continuous flow multi-step organic synthesis

(2010) Damien Webb et al.   Chemical Science

Manufacturing peptides as active pharmaceutical ingredients

(2009) Aikaterini A Zompra et al.   Future Medicinal Chemistry

The Structure of theStaphylococcus aureusSortase-Substrate Complex Reveals How the Universally Conserved LPXTG Sorting Signal Is Recognized

(2009) Nuttee Suree et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Total chemical synthesis of proteins

(2008) Stephen B. H. Kent   CHEMICAL SOCIETY REVIEWS