Progress and challenges in the use of latent HIV-1 reactivating agents

Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cδ–NF-κB signaling

(2014) Guochun Jiang et al.   AIDS

Emerging Trends of HIV Drug Resistance in Chinese HIV-Infected Patients Receiving First-Line Highly Active Antiretroviral Therapy: A Systematic Review and Meta-Analysis

(2014) Huixin Liu et al.   CLINICAL INFECTIOUS DISEASES

Potential mechanisms for cell-based gene therapy to treat HIV/AIDS

(2014) Elena Herrera-Carrillo et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

HIV-1 transcriptional regulation in the central nervous system and implications for HIV cure research

(2014) Melissa J. Churchill et al.   JOURNAL OF NEUROVIROLOGY

Reactivation of latent HIV-1 by new semi-synthetic ingenol esters

(2014) Diego Pandeló José et al.   VIROLOGY

The Emerging Profile of Cross-Resistance among the Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors

(2014) Nicolas Sluis-Cremer   Viruses-Basel

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

(2014) Datsen George Wei et al.   PLoS Pathogens

Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells

(2013) Fiona Wightman et al.   AIDS

BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism

(2013) Daniela Boehm et al.   CELL CYCLE

A Pilot Study Assessing the Safety and Latency-Reversing Activity of Disulfiram in HIV-1-Infected Adults on Antiretroviral Therapy

(2013) A. M. Spivak et al.   CLINICAL INFECTIOUS DISEASES

Is specific HIV eradication from the brain possible or needed?

(2013) Bruce J Brew et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Negative Elongation Factor (NELF) Coordinates RNA Polymerase II Pausing, Premature Termination, and Chromatin Remodeling to Regulate HIV Transcription

(2013) Malini Natarajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The search for an HIV cure: tackling latent infection

(2013) Stephen J Kent et al.   LANCET INFECTIOUS DISEASES

Molecular and pathologic insights from latent HIV-1 infection in the human brain

(2013) P. Desplats et al.   NEUROLOGY

Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo

(2013) E. J. Beans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular and molecular mechanisms involved in the establishment of HIV-1 latency

(2013) Daniel A Donahue et al.   Retrovirology

Comparison of HDAC inhibitors in clinical development

(2013) Thomas Aagaard Rasmussen et al.   Human Vaccines & Immunotherapeutics

Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4+ T cells from HIV-1-infected HAART-treated patients

(2012) Sophie Bouchat et al.   AIDS

Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog

(2012) Geneviève Doyon et al.   AIDS

Control of HIV Latency by Epigenetic and Non-Epigenetic Mechanisms

(2012) Jonathan Karn et al.   CURRENT HIV RESEARCH

Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation

(2012) Liang Shan et al.   IMMUNITY

A dedicated clinic for HIV-positive individuals over 50 years of age: a multidisciplinary experience

(2012) L Waters et al.   INTERNATIONAL JOURNAL OF STD & AIDS

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

Shock and kill

(2012) Steven G. Deeks   NATURE

A Flexible Model of HIV-1 Latency Permitting Evaluation of Many Primary CD4 T-Cell Reservoirs

(2012) Kara G. Lassen et al.   PLoS One

The Control of HIV Transcription: Keeping RNA Polymerase II on Track

(2011) Melanie Ott et al.   Cell Host & Microbe

Mocetinostat (MGCD0103): a review of an isotype-specific histone deacetylase inhibitor

(2011) Yanis Boumber et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV-1 without producing a T cell response

(2011) Wendy Bernhard et al.   FEBS LETTERS

HDAC inhibitors in HIV

(2011) Fiona Wightman et al.   IMMUNOLOGY AND CELL BIOLOGY

Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation

(2011) Sifei Xing et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

High-throughput Screening Uncovers a Compound That Activates Latent HIV-1 and Acts Cooperatively with a Histone Deacetylase (HDAC) Inhibitor

(2011) Sofiya Micheva-Viteva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Replication and Latency Are Regulated by Translational Control of Cyclin T1

(2011) Mainul Hoque et al.   JOURNAL OF MOLECULAR BIOLOGY

T-Cell Receptor Signaling Enhances Transcriptional Elongation from Latent HIV Proviruses by Activating P-TEFb through an ERK-Dependent Pathway

(2011) Young Kyeung Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

Influence of Host Gene Transcription Level and Orientation on HIV-1 Latency in a Primary-Cell Model

(2011) L. Shan et al.   JOURNAL OF VIROLOGY

Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2

(2011) J. Friedman et al.   JOURNAL OF VIROLOGY

Chromatin Reassembly Factors Are Involved in Transcriptional Interference Promoting HIV Latency

(2011) E. Gallastegui et al.   JOURNAL OF VIROLOGY

Disulfiram Reactivates Latent HIV-1 in a Bcl-2-Transduced Primary CD4+ T Cell Model without Inducing Global T Cell Activation

(2011) S. Xing et al.   JOURNAL OF VIROLOGY

Unknown

(2011) Shay Matalon et al.   MOLECULAR MEDICINE

Involvement of Histone H3 Lysine 9 (H3K9) Methyltransferase G9a in the Maintenance of HIV-1 Latency and Its Reactivation by BIX01294

(2010) Kenichi Imai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Establishment of HIV Latency in Primary CD4+ Cells Is due to Epigenetic Transcriptional Silencing and P-TEFb Restriction

(2010) M. Tyagi et al.   JOURNAL OF VIROLOGY

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Cell line-dependent variability in HIV activation employing DNMT inhibitors

(2010) Guerau Fernandez et al.   Virology Journal

NF-κB/Rel: agonist and antagonist roles in HIV-1 latency

(2010) Jonathan KL Chan et al.   Current Opinion in HIV and AIDS

The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit

(2010) Jonathan Karn   Current Opinion in HIV and AIDS

Prolonged valproic acid treatment does not reduce the size of latent HIV reservoir

(2009) Nathalie Sagot-Lerolle et al.   AIDS

Pharmaceutical approaches to eradication of persistent HIV infection

(2009) Mary-Catherine Bowman et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Determinants of the Establishment of Human Immunodeficiency Virus Type 1 Latency

(2009) A. Duverger et al.   JOURNAL OF VIROLOGY

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

(2009) T. B. Miranda et al.   MOLECULAR CANCER THERAPEUTICS

Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies

(2009) Laurence Colin et al.   Retrovirology

Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation

(2009) Steven E. Kauder et al.   PLoS Pathogens

Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells

(2008) Nancy M Archin et al.   AIDS

Factors Controlling Chromatin Organization and Nucleosome Positioning for Establishment and Maintenance of HIV Latency

(2008) Ivan Sadowski et al.   CURRENT HIV RESEARCH

Eradication of HIV: current challenges and new directions

(2008) M. D. Marsden et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Hexamethylbisacetamide and Disruption of Human Immunodeficiency Virus Type 1 Latency in CD4+T Cells

(2008) Shailesh K. Choudhary et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 latency in actively dividing human T cell lines

(2008) Rienk E Jeeninga et al.   Retrovirology