Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy

Review of Biomarkers in Ocular Matrices: Challenges and Opportunities

(2019) Mitalee Tamhane et al.   PHARMACEUTICAL RESEARCH

N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration

(2018) Chia-yi Chen et al.   MATRIX BIOLOGY

A Proteomics Approach to Identify Candidate Proteins Secreted by Müller Glia that Protect Ganglion Cells in the Retina

(2018) Noelia Ruzafa et al.   PROTEOMICS

HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model

(2018) Esther Melo et al.   EBioMedicine

Age-related macular degeneration

(2018) Paul Mitchell et al.   LANCET

Dickkopf-3 Causes Neuroprotection by Inducing Vascular Endothelial Growth Factor

(2018) Carla Letizia Busceti et al.   Frontiers in Cellular Neuroscience

Interphotoreceptor retinoid–binding protein removes all-trans-retinol and retinal from rod outer segments, preventing lipofuscin precursor formation

(2017) Chunhe Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DKK3 (Dickkopf 3) Alters Atherosclerotic Plaque Phenotype Involving Vascular Progenitor and Fibroblast Differentiation Into Smooth Muscle Cells

(2017) Eirini Karamariti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The unconventional secretion of ARMS2

(2016) Elod Kortvely et al.   HUMAN MOLECULAR GENETICS

MicroRNA signatures in vitreous humour and plasma of patients with exudative AMD

(2016) Catherine Ménard et al.   Oncotarget

The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody

(2015) C. Ciferri et al.   BIOCHEMICAL JOURNAL

Structure and function of the interphotoreceptor matrix surrounding retinal photoreceptor cells

(2015) Makoto Ishikawa et al.   EXPERIMENTAL EYE RESEARCH

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

(2015) Lars G Fritsche et al.   NATURE GENETICS

COMPARISON OF DRUSEN AND MODIFYING GENES IN AUTOSOMAL DOMINANT RADIAL DRUSEN AND AGE-RELATED MACULAR DEGENERATION

(2015) Elliott H. Sohn et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

The Autolysis of Human HtrA1 Is Governed by the Redox State of Its N-Terminal Domain

(2014) Michael W. Risør et al.   BIOCHEMISTRY

Thiol-dependent antioxidant activity of interphotoreceptor retinoid-binding protein

(2014) Federico Gonzalez-Fernandez et al.   EXPERIMENTAL EYE RESEARCH

Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling

(2014) Nathalie Beaufort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of age-related macular degeneration and therapeutic opportunities

(2013) Menno van Lookeren Campagne et al.   JOURNAL OF PATHOLOGY

Structural and Functional Analysis of HtrA1 and Its Subdomains

(2012) Charles Eigenbrot et al.   STRUCTURE

Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products

(2010) Oded Kleifeld et al.   NATURE BIOTECHNOLOGY

Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening

(2009) Jeremy Chien et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Improved visualization of protein consensus sequences by iceLogo

(2009) Niklaas Colaert et al.   NATURE METHODS

Association of HTRA1 Mutations and Familial Ischemic Cerebral Small-Vessel Disease

(2009) Kenju Hara et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Impact of Peptide Abundance and Dynamic Range on Stable-Isotope-Based Quantitative Proteomic Analyses

(2008) Corey E. Bakalarski et al.   JOURNAL OF PROTEOME RESEARCH