Hydrogen deuterium exchange defines catalytically linked regions of protein flexibility in the catechol O-methyltransferase reaction

Protein Flexibility and Stiffness Enable Efficient Enzymatic Catalysis

(2019) John P. Richard   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol-O-methyltransferase

(2019) Sylwia Czarnota et al.   ACS Catalysis

Detecting and Characterizing the Kinetic Activation of Thermal Networks in Proteins: Thermal Transfer from a Distal, Solvent-Exposed Loop to the Active Site in Soybean Lipoxygenase

(2019) Jan Paulo T. Zaragoza et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Activity-Related Microsecond Dynamics Revealed by Temperature-Jump Förster Resonance Energy Transfer Measurements on Thermophilic Alcohol Dehydrogenase

(2018) Morgan B. Vaughn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Reaction Mechanism in Native and Mutant Catechol-O-methyltransferase from the Adaptive String Method and Mean Reaction Force Analysis

(2018) David Adrian Saez et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A Biophysical Perspective on Enzyme Catalysis

(2018) Pratul K. Agarwal   BIOCHEMISTRY

Origins of Enzyme Catalysis: Experimental Findings for C–H Activation, New Models, and Their Relevance to Prevailing Theoretical Constructs

(2017) Judith P. Klinman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydrogen–Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling

(2017) Adam R. Offenbacher et al.   ACS Central Science

Hydrostatic Pressure Studies Distinguish Global from Local Protein Motions in C−H Activation by Soybean Lipoxygenase-1

(2016) Shenshen Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Influence of Equatorial CH⋅⋅⋅O Interactions on Secondary Kinetic Isotope Effects for Methyl Transfer

(2016) Philippe B. Wilson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Kinetic stability of cystathionine beta-synthase can be modulated by structural analogs of S-adenosylmethionine: Potential approach to pharmacological chaperone therapy for homocystinuria

(2016) Tomas Majtan et al.   BIOCHIMIE

The TIM Barrel Architecture Facilitated the Early Evolution of Protein-Mediated Metabolism

(2016) Aaron David Goldman et al.   JOURNAL OF MOLECULAR EVOLUTION

How Large Should the QM Region Be in QM/MM Calculations? The Case of Catechol O-Methyltransferase

(2016) Heather J. Kulik et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Convergent Mechanistic Features between the Structurally Diverse N- and O-Methyltransferases: Glycine N-Methyltransferase and Catechol O-Methyltransferase

(2016) Jianyu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electric-field-stimulated protein mechanics

(2016) Doeke R. Hekstra et al.   NATURE

On the relationship between low-frequency normal modes and the large-scale conformational changes of proteins

(2015) Swapnil Mahajan et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Protein motions and dynamic effects in enzyme catalysis

(2015) Louis Y. P. Luk et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Mediation of donor–acceptor distance in an enzymatic methyl transfer reaction

(2015) Jianyu Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

(2015) Yongqian Zhao et al.   PLoS Pathogens

The Dynamical Nature of Enzymatic Catalysis

(2014) Robert Callender et al.   ACCOUNTS OF CHEMICAL RESEARCH

Picosecond-Resolved Fluorescent Probes at Functionally Distinct Tryptophans within a Thermophilic Alcohol Dehydrogenase: Relationship of Temperature-Dependent Changes in Fluorescence to Catalysis

(2014) Corey W. Meadows et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Picosecond-Resolved Fluorescence Studies of Substrate and Cofactor-Binding Domain Mutants in a Thermophilic Alcohol Dehydrogenase Uncover an Extended Network of Communication

(2014) Corey W. Meadows et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydrogen Tunneling Links Protein Dynamics to Enzyme Catalysis

(2013) Judith P. Klinman et al.   Annual Review of Biochemistry

Identification of a Long-range Protein Network That Modulates Active Site Dynamics in Extremophilic Alcohol Dehydrogenases

(2013) Zachary D. Nagel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human cystathionine β-synthase (CBS) contains two classes of binding sites forS-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM

(2012) Angel L. Pey et al.   BIOCHEMICAL JOURNAL

Protein dynamics and enzyme catalysis: the ghost in the machine?

(2012) David R. Glowacki et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Active Site Hydrophobic Residues Impact Hydrogen Tunneling Differently in a Thermophilic Alcohol Dehydrogenase at Optimal versus Nonoptimal Temperatures

(2012) Zachary D. Nagel et al.   BIOCHEMISTRY

S-Adenosyl-Methionine-Dependent Methyltransferases: Highly Versatile Enzymes in Biocatalysis, Biosynthesis and Other Biotechnological Applications

(2012) Anna-Winona Struck et al.   CHEMBIOCHEM

Time-resolved structural studies at synchrotrons and X-ray free electron lasers: opportunities and challenges

(2012) Richard Neutze et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Kinetics and thermodynamics of binding reactions as exemplified by anthrax toxin channel blockage with a cationic cyclodextrin derivative

(2012) E. M. Nestorovich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

(2012) Wenyu Yu et al.   Nature Communications

Comparative Hydrogen–Deuterium Exchange for a Mesophilic vs Thermophilic Dihydrofolate Reductase at 25 °C: Identification of a Single Active Site Region with Enhanced Flexibility in the Mesophilic Protein

(2011) Olayinka A. Oyeyemi et al.   BIOCHEMISTRY

Enzymatic Methyl Transfer: Role of an Active Site Residue in Generating Active Site Compaction That Correlates with Catalytic Efficiency

(2011) Jianyu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors

(2011) Z. D. Nagel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen exchange mass spectrometry: what is it and what can it tell us?

(2010) Sean R. Marcsisin et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Hydrogen exchange mass spectrometry for studying protein structure and dynamics

(2010) Lars Konermann et al.   CHEMICAL SOCIETY REVIEWS

Large conformational changes in proteins: signaling and other functions

(2010) Barry J Grant et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A role for flexible loops in enzyme catalysis

(2010) M Merced Malabanan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Temperature dependence of protein motions in a thermophilic dihydrofolate reductase and its relationship to catalytic efficiency

(2010) O. A. Oyeyemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hidden alternative structures of proline isomerase essential for catalysis

(2009) James S. Fraser et al.   NATURE

The far reaches of enzymology

(2009) Jesse G Zalatan et al.   Nature Chemical Biology

Enzymatic transition states and dynamic motion in barrier crossing

(2009) Steven D Schwartz et al.   Nature Chemical Biology

A unified model of protein dynamics

(2009) H. Frauenfelder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Free-Energy Landscape of Enzyme Catalysis†

(2008) Stephen J. Benkovic et al.   BIOCHEMISTRY

Crystal Structures of Human 108V and 108M Catechol O-Methyltransferase

(2008) K. Rutherford et al.   JOURNAL OF MOLECULAR BIOLOGY