Epileptic brain fluorescent imaging reveals apigenin can relieve the myeloperoxidase-mediated oxidative stress and inhibit ferroptosis

New Quinolylnitrones for Stroke Therapy: Antioxidant and Neuroprotective (Z)-N-tert-Butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine Oxide as a New Lead-Compound for Ischemic Stroke Treatment

(2019) Mourad Chioua et al.   JOURNAL OF MEDICINAL CHEMISTRY

Illuminating the Function of the Hydroxyl Radical in the Brains of Mice with Depression Phenotypes by Two-Photon Fluorescence Imaging

(2019) Xin Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel Quinolylnitrones Combining Neuroprotective and Antioxidant Properties

(2019) Mourad Chioua et al.   ACS Chemical Neuroscience

Bright AIEgen–Protein Hybrid Nanocomposite for Deep and High‐Resolution In Vivo Two‐Photon Brain Imaging

(2019) Shaowei Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Design, synthesis and biological evaluation of a series of CNS penetrant HDAC inhibitors structurally derived from amyloid-β probes

(2019) Myeong A Choi et al.   Scientific Reports

Myeloperoxidase and Neurological Disorder: A Crosstalk

(2018) Kanta Pravalika et al.   ACS Chemical Neuroscience

Versatile Histochemical Approach to Detection of Hydrogen Peroxide in Cells and Tissues Based on Puromycin Staining

(2018) Clive Yik-Sham Chung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design of a ratiometric two-photon probe for imaging of hypochlorous acid (HClO) in wounded tissues

(2018) Zhiqiang Mao et al.   Chemical Science

Deformylation reaction-based probe for in vivo imaging of HOCl

(2018) Peng Wei et al.   Chemical Science

Rationally Designed Fluorescence . OH Probe with High Sensitivity and Selectivity for Monitoring the Generation of . OH in Iron Autoxidation without Addition of H2 O2

(2018) Hongyu Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective Monitoring and Imaging of Eosinophil Peroxidase Activity with a J-Aggregating Probe

(2018) Tae-Il Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxalate-curcumin–based probe for micro- and macroimaging of reactive oxygen species in Alzheimer’s disease

(2017) Jian Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging of formaldehyde in plants with a ratiometric fluorescent probe

(2017) Zhen Li et al.   Chemical Science

Highly Specific and Ultrasensitive Two-Photon Fluorescence Imaging of Native HOCl in Lysosomes and Tissues Based on Thiocarbamate Derivatives

(2016) Baocun Zhu et al.   ANALYTICAL CHEMISTRY

A Selective Imidazoline-2-thione-Bearing Two-Photon Fluorescent Probe for Hypochlorous Acid in Mitochondria

(2016) Qingling Xu et al.   ANALYTICAL CHEMISTRY

Activity-Based Proteome Profiling Probes Based on Woodward's Reagent K with Distinct Target Selectivity

(2016) Yong Qian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New Hydroxyquinoline-Based Derivatives as Potent Modulators of Amyloid-β Aggregations

(2016) Chin-Lan Fu et al.   ARCHIV DER PHARMAZIE

Real-Time Discrimination and Versatile Profiling of Spontaneous Reactive Oxygen Species in Living Organisms with a Single Fluorescent Probe

(2016) Ruilong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloperoxidase Nuclear Imaging for Epileptogenesis

(2016) Yinian Zhang et al.   RADIOLOGY

HKOCl-3: a fluorescent hypochlorous acid probe for live-cell and in vivo imaging and quantitative application in flow cytometry and a 96-well microplate assay

(2016) Jun Jacob Hu et al.   Chemical Science

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

(2016) Shang-Jui Wang et al.   Cell Reports

SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease

(2016) Xianxiu Wan et al.   PLoS Pathogens

Development of Imidazoline-2-Thiones Based Two-Photon Fluorescence Probes for Imaging Hypochlorite Generation in a Co-Culture System

(2015) Qingling Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inflaming the diseased brain: a role for tainted melanins

(2015) T.M. Jeitner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Small-Molecule Two-Photon Probes for Bioimaging Applications

(2015) Hwan Myung Kim et al.   CHEMICAL REVIEWS

Myeloperoxidase Propagates Damage and is a Potential Therapeutic Target for Subacute Stroke

(2015) Reza Forghani et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Two-Photon Absorbing Dyes with Minimal Autofluorescence in Tissue Imaging: Application to in Vivo Imaging of Amyloid-β Plaques with a Negligible Background Signal

(2015) Dokyoung Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visualizing Peroxynitrite Fluxes in Endothelial Cells Reveals the Dynamic Progression of Brain Vascular Injury

(2015) Xin Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of Targetable Two-Photon Fluorescent Probes to Image Hypochlorous Acid in Mitochondria and Lysosome in Live Cell and Inflamed Mouse Model

(2015) Lin Yuan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease

(2015) Chun-Hyung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

A Fast and Selective Near-Infrared Fluorescent Sensor for Multicolor Imaging of Biological Nitroxyl (HNO)

(2014) Alexandra T. Wrobel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An “Enhanced PET”-Based Fluorescent Probe with Ultrasensitivity for Imaging Basal and Elesclomol-Induced HClO in Cancer Cells

(2014) Hao Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Smart Near-Infrared Fluorescence Probes with Donor–Acceptor Structure for in Vivo Detection of β-Amyloid Deposits

(2014) Mengchao Cui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Engineering of a TBET-Based Two-Photon Fluorescent Probe for Ratiometric Imaging of Living Cells and Tissues

(2014) Liyi Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CAPON-nNOS coupling can serve as a target for developing new anxiolytics

(2014) Li-Juan Zhu et al.   NATURE MEDICINE

Repeated exposure to low doses of kainic acid activates nuclear factor kappa B (NF-κB) prior to seizure in transgenic NF-κB/EGFP reporter mice

(2014) James A. Miller et al.   NEUROTOXICOLOGY

Quantitation of Hydrogen Peroxide Fluctuations and Their Modulation of Dopamine Dynamics in the Rat Dorsal Striatum Using Fast-Scan Cyclic Voltammetry

(2013) Marina Spanos et al.   ACS Chemical Neuroscience

Oxidative Cleavage-Based Near-Infrared Fluorescent Probe for Hypochlorous Acid Detection and Myeloperoxidase Activity Evaluation

(2013) Mingtai Sun et al.   ANALYTICAL CHEMISTRY

Design and Synthesis of Curcumin Analogues for in Vivo Fluorescence Imaging and Inhibiting Copper-Induced Cross-Linking of Amyloid Beta Species in Alzheimer’s Disease

(2013) Xueli Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

pH-Dependent Si-Fluorescein Hypochlorous Acid Fluorescent Probe: Spirocycle Ring-Opening and Excess Hypochlorous Acid-Induced Chlorination

(2013) Quinn A. Best et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The kainic acid model of temporal lobe epilepsy

(2013) Maxime Lévesque et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

NGF and nitrosative stress in patients with Huntington's disease

(2012) Inmaculada Tasset et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Reaction-based small-molecule fluorescent probes for chemoselective bioimaging

(2012) Jefferson Chan et al.   Nature Chemistry

Principles for designing fluorescent sensors and reporters

(2011) Edward A Lemke et al.   Nature Chemical Biology

Myeloperoxidase Inhibition Ameliorates Multiple System Atrophy-Like Degeneration in a Transgenic Mouse Model

(2011) Nadia Stefanova et al.   NEUROTOXICITY RESEARCH

Protective effects and mechanisms of sirtuins in the nervous system

(2011) Feng Zhang et al.   PROGRESS IN NEUROBIOLOGY

Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation

(2010) Valerian E. Kagan et al.   Nature Nanotechnology

New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging

(2009) Hisataka Kobayashi et al.   CHEMICAL REVIEWS