Journal
CHEMISTRY & BIODIVERSITY
Volume 13, Issue 12, Pages 1707-1714Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201600127
Keywords
Kalanchoe daigremontiana; Flavonoids; Kaempferol triglycoside; Antiviral activity; Herpes viruses
Funding
- CAPES (Brazil)
- CNPq (Brazil)
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Kalanchoe daigremontiana (Crassulaceae) is a medicinal plant native to Madagascar. The aim of this study was to investigate the flavonoid content of an aqueous leaf extract from K. daigremontiana (Kd), and assess its antiherpetic potential. The major flavonoid, kaempferol 3-O-beta-D-xylopyranosyl-(1 -> 2)-alpha-L-rhamnopyranoside (1), was isolated from the AcOEt fraction (Kd-AC). The BuOH-soluble fraction afforded quercetin 3-O-beta-D-xylopyranosyl-(1 -> 2)-alpha-L-rhamnopyranoside (2) and the new kaempferol 3-O-beta-D-xylopyranosyl-(1 -> 2)-alpha-L-rhamnopyranoside-7-O-beta-D-glucopyranoside (3), named daigremontrioside. The crude extract, Kd-AC fraction, flavonoids 1 and 2 were evaluated using acyclovir-sensitive strains of HSV-1 and HSV-2. Kd-AC was highly active against HSV-1 (EC50 = 0.97 mu g/ml, SI > 206.1) and HSV-2 (EC50 = 0.72 mu g/ml, SI > 277.7). Flavonoids 1 and 2 showed anti-HSV-1 (EC50 = 7.4 mu g/ml; SI > 27 and EC50 = 5.8 mu g/ml; SI > 8.6, respectively) and anti-HSV-2 (EC50 = 9.0 mu g/ml; SI > 22.2 and EC50 = 36.2 mu g/ml; SI > 5.5, respectively) activities, suggesting the contribution of additional substances to the antiviral activity.
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