Journal
CHEMISTRY & BIODIVERSITY
Volume 13, Issue 7, Pages 884-890Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201500282
Keywords
Solanaceae; Physalis minima; Withanolides; 13,14-seco-Withaphysalin; Nitric oxide
Funding
- Fundamental Research Funds for the Central Universities [JKZD2013008]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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Four new 13,14-seco-withanolides, minisecolides A - D (1 - 4), together with three known analogues 5 - 7, were isolated from the whole plants of Physalis minima. The structures of new compounds were determined on the basis of spectroscopic analysis, including H-1-, C-13-NMR, 2D-NMR (HMBC, HSQC, ROESY), and HR-ESI-MS. Evaluation of all isolates for their inhibitory effects on nitric oxide (NO) production was conducted on lipopolysaccaride-activated RAW264.7 macrophages. Compounds 2, 3, 5, and 6 showed inhibitory activities, especially for compound 5 with IC50 value of 3.87 mu M.
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