Natural products and their derivatives against coronavirus: A review of the non‐clinical and pre‐clinical data

Virus against virus: a potential treatment for 2019-nCov (SARS-CoV-2) and other RNA viruses

(2020) Tuan M. Nguyen et al.   CELL RESEARCH

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Origin and Evolution of the 2019 Novel Coronavirus

(2020) Liangsheng Zhang et al.   CLINICAL INFECTIOUS DISEASES

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges

(2020) Chih-Cheng Lai et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health — The latest 2019 novel coronavirus outbreak in Wuhan, China

(2020) David S. Hui et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Pneumonia of unknown aetiology in Wuhan, China: potential for international spread via commercial air travel

(2020) Isaac I Bogoch et al.   JOURNAL OF TRAVEL MEDICINE

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Emerging novel coronavirus (2019-nCoV)—current scenario, evolutionary perspective based on genome analysis and recent developments

(2020) Yashpal Singh Malik et al.   VETERINARY QUARTERLY

Characteristics of and Public Health Responses to the Coronavirus Disease 2019 Outbreak in China

(2020) Sheng-Qun Deng et al.   Journal of Clinical Medicine

High-throughput Screening and Identification of Potent Broad-spectrum Inhibitors of Coronaviruses

(2019) Liang Shen et al.   JOURNAL OF VIROLOGY

Coronavirus envelope protein: current knowledge

(2019) Dewald Schoeman et al.   Virology Journal

Natural Bis-Benzylisoquinoline Alkaloids-Tetrandrine, Fangchinoline, and Cepharanthine, Inhibit Human Coronavirus OC43 Infection of MRC-5 Human Lung Cells

(2019) Kim et al.   Biomolecules

Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals

(2019) Elizabeth M. Williamson et al.   BRITISH JOURNAL OF PHARMACOLOGY

Best practice in research – Overcoming common challenges in phytopharmacological research

(2019) Michael Heinrich et al.   JOURNAL OF ETHNOPHARMACOLOGY

Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses

(2018) Christin Müller et al.   ANTIVIRAL RESEARCH

Plant-derived antivirals against hepatitis c virus infection

(2018) Ana Carolina Gomes Jardim et al.   Virology Journal

MERS-CoV: Understanding the Latest Human Coronavirus Threat

(2018) et al.   Viruses-Basel

The cardenolide ouabain suppresses coronaviral replication via augmenting a Na+/K+-ATPase-dependent PI3K_PDK1 axis signaling

(2018) Cheng-Wei Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Promising approaches for the treatment and prevention of viral respiratory illnesses

(2017) Nikolaos G. Papadopoulos et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors

(2017) Ji-Young Park et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses

(2017) Ana Flávia Costa da Silveira Oliveira et al.   MOLECULES

Evaluation of antiviral activities of Houttuynia cordata Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection

(2016) K.H. Chiow et al.   Asian Pacific Journal of Tropical Medicine

Structure, Function, and Evolution of Coronavirus Spike Proteins

(2016) Fang Li   Annual Review of Virology

A screen of the NIH Clinical Collection small molecule library identifies potential anti-coronavirus drugs

(2015) Jianzhong Cao et al.   ANTIVIRAL RESEARCH

Potential Antiviral Agents from Marine Fungi: An Overview

(2015) Soheil Moghadamtousi et al.   Marine Drugs

Potential Anti-HPV and Related Cancer Agents from Marine Resources: An Overview

(2014) Shi-Xin Wang et al.   Marine Drugs

The effects of Nigella sativa (Ns), Anthemis hyalina (Ah) and Citrus sinensis (Cs) extracts on the replication of coronavirus and the expression of TRP genes family

(2014) Mustafa Ulasli et al.   MOLECULAR BIOLOGY REPORTS

Evidence for Camel-to-Human Transmission of MERS Coronavirus

(2014) Esam I. Azhar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Kaempferol Derivatives as Antiviral Drugs against the 3a Channel Protein of Coronavirus

(2014) Silvia Schwarz et al.   PLANTA MEDICA

Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities

(2014) Anna M. Mielech et al.   VIRUS RESEARCH

In vitro antiviral activity of phlorotannins isolated from Ecklonia cava against porcine epidemic diarrhea coronavirus infection and hemagglutination

(2013) Hyung-Jun Kwon et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Geranylated flavonoids displaying SARS-CoV papain-like protease inhibition from the fruits of Paulownia tomentosa

(2013) Jung Keun Cho et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds ofPsoralea corylifolia

(2013) Dae Wook Kim et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases

(2012) Ji-Young Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13

(2012) Mi-Sun Yu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A facile inhibitor screening of SARS coronavirus N protein using nanoparticle-based RNA oligonucleotide

(2012) Changhyun Roh   International Journal of Nanomedicine

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metabolome Classification of CommercialHypericum perforatum(St. John's Wort) Preparations via UPLC-qTOF-MS and Chemometrics

(2012) Mohamed Farag et al.   PLANTA MEDICA

Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice

(2011) Jincun Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of phenanthroindolizines and phenanthroquinolizidines as novel potent anti-coronaviral agents for porcine enteropathogenic coronavirus transmissible gastroenteritis virus and human severe acute respiratory syndrome coronavirus

(2010) Cheng-Wei Yang et al.   ANTIVIRAL RESEARCH

Synthetic biology approaches in drug discovery and pharmaceutical biotechnology

(2010) Heinz Neumann et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition

(2010) Young Bae Ryu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A structural analysis of M protein in coronavirus assembly and morphology

(2010) Benjamin W. Neuman et al.   JOURNAL OF STRUCTURAL BIOLOGY

T Cell Responses Are Required for Protection from Clinical Disease and for Virus Clearance in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice

(2010) J. Zhao et al.   JOURNAL OF VIROLOGY

Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection

(2009) Min Zhuang et al.   ANTIVIRAL RESEARCH

Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

(2009) S. Belouzard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunomodulatory and anti-SARS activities of Houttuynia cordata

(2008) Kit-Man Lau et al.   JOURNAL OF ETHNOPHARMACOLOGY

Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication

(2008) Chung-Jen Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

The M, E, and N Structural Proteins of the Severe Acute Respiratory Syndrome Coronavirus Are Required for Efficient Assembly, Trafficking, and Release of Virus-Like Particles

(2008) Y. L. Siu et al.   JOURNAL OF VIROLOGY