Article
Plant Sciences
Xiao-Rui Zhang, Yi-Jun Qiao, Hong-Tao Zhu, Qing-Hua Kong, Dong Wang, Chong-Ren Yang, Ying-Jun Zhang
Summary: The main active ingredients of Terminalia chebula fruits are lignans and hydrolyzed tannins, which are responsible for traditional treatment of sore throat and cough. These compounds also show potential hypoglycemic activity, supporting the ethno-pharmacological uses of the fruit in treating diabetes in Tibetan medicine.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ryszard Amarowicz, Ronald B. Pegg
Summary: Lentils are a good source of plant protein and essential nutrients, and they also contain healthful bioactive compounds such as phenolic compounds. The levels of phenolic compounds in lentils vary due to factors like cultivars, horticultural practices, and phenolic extraction approaches. Lentil extracts show significant antioxidant activity, and processing methods like cooking, germination, and fermentation can affect the phenolic content. Lentil extracts have also demonstrated positive biological activities in cell culture and animal studies.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Biology
Ojaskumar D. Agrawal, Yogesh A. Kulkarni
Summary: The aqueous extract of Terminalia chebula fruits showed significant effects in reducing plasma glucose levels, improving lipid parameters, and enhancing insulin sensitivity in type 2 diabetic rats. It also demonstrated a protective effect on pancreatic tissue.
Review
Food Science & Technology
Muhammad Tauseef Sultan, Muhammad Junaid Anwar, Muhammad Imran, Ijaz Khalil, Farhan Saeed, Shahzadi Neelum, Suliman A. Alsagaby, Waleed Al Abdulmonem, Mohamed A. Abdelgawad, Muzzamal Hussain, Ahmed H. El-Ghorab, Maryam Umar, Entessar Al Jbawi
Summary: Globalization has led to changes in consumer markets, resulting in long-term impacts on lifestyle and dietary choices. While pharmaceutical and chemical research has saved lives, their persistent use has raised safety and toxicological concerns. Researchers have turned to traditional medicines, such as those used in Chinese and Ayurveda practices, to validate their therapeutic applications. This article focuses on the myrobalan plant, which has been extensively used in Ayurveda for its various health benefits. The article presents its phytochemical profile and highlights its medicinal properties, including antioxidant, antimicrobial, anti-inflammatory, hypoglycemic, and digestive tonic effects. It also discusses its potential applications in treating cardiovascular disorders, immune dysfunction, cancer, and neurological disorders, as well as its inclusion in the modern functional food market and future prospects.
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2023)
Article
Chemistry, Applied
Joana Azevedo, Monica Jesus, Elsa Brandao, Susana Soares, Joana Oliveira, Paulo Lopes, Nuno Mateus, Victor de Freitas
Summary: The study investigates the interaction between human salivary proteins and phenolic compounds migrating from cork stoppers to wine. Different cork fractions contain various compounds that react differently with salivary proteins, indicating a potential influence on the sensory perception of wine. Among the compounds, ellagitannins show higher reactivity with salivary proteins, especially in precipitating aPRPs, statherin, and P-B peptide. Additionally, the presence of other compounds may also impact these interactions.
Review
Agricultural Engineering
Mauricio M. de Souza Ribeiro, Luana C. dos Santos, Nathalia S. de Novais, Juliane Vigano, Priscila C. Veggi
Summary: The search for natural products as alternatives to synthetic products is increasing due to health concerns and the desire for a better quality of life. Extracting bioactive compounds from plants, such as Stryphnodendron adstringens (Barbatimao), offers promising strategies for pharmaceutical and food applications. The specific knowledge of extraction techniques and sustainability of the production chain are essential for obtaining high-purity extracts. This review provides updated information on Barbatimao extracts, including their biological activities, extraction techniques, and chemical composition. It also highlights the need for future research to explore the potential use of this species.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Munusamy Tharani, Shanmugam Rajeshkumar, Khalid A. Al-Ghanim, Marcello Nicoletti, Nadezhda Sachivkina, Marimuthu Govindarajan
Summary: In this study, an aqueous extract from Terminalia chebula fruit was effectively utilized to produce silver nanoparticles (Ag NPs) in an eco-friendly manner. Characterization using UV-visible spectrophotometry, transmission electron microscopy (TEM), and scanning electron microscopy (SEM) showed that the synthesized Ag NPs were spherical with an average size of around 50 nm and exhibited significant antibacterial and antioxidant activities. Additionally, toxicity evaluation using zebrafish embryos as a model organism indicated no significant toxic effects, further supporting the potential therapeutic applications of the synthesized Ag NPs.
Review
Chemistry, Applied
Fabio Fernandes de Araujo, David de Paulo Farias, Iramaia Angelica Neri-Numa, Glaucia Maria Pastore
Summary: Polyphenols are naturally occurring compounds present in fruits and vegetables, with various biological effects and industrial applications. Adequate intake of polyphenols can help prevent diseases and improve the properties of starch, as well as contribute to innovation in different technological fields.
Review
Biochemistry & Molecular Biology
Sotirios Kiokias, Vassiliki Oreopoulou
Summary: Phenolic acids are phytochemical compounds with antioxidant and anti-inflammatory properties, commonly found in edible botanicals like thyme and oregano. Recent clinical studies have focused on their potential health benefits against severe diseases such as cancer and cardiovascular diseases.
Article
Chemistry, Multidisciplinary
Rita Petrucci, Martina Bortolami, Paola Di Matteo, Antonella Curulli
Summary: This review discusses the applications of gold nanomaterials in the rapid and selective detection of phenolic compounds, as well as the selection of gold nanomaterials involved in designing such sensors. The importance of gold nanomaterials lies in their relevant bioactivity and importance in several sectors, such as agro-food, pharmaceutical, and cosmetic.
Article
Biochemistry & Molecular Biology
Akanksha Tyagi, Min-Jin Lim, Nam-Hyeon Kim, Kaliyan Barathikannan, Selvakumar Vijayalakshmi, Fazle Elahi, Hun-Ju Ham, Deog-Hwan Oh
Summary: This study evaluated the antioxidant properties and bioactive compound content of nine Korean rice varieties using various analysis methods. The results showed that colored rice varieties are high in amino acids, phenolic compounds, and antioxidants. This research provides valuable insights into the nutritional value of different colored rice and their potential as natural antioxidants.
Article
Chemistry, Applied
Qiqi Cao, Jianwen Teng, Baoyao Wei, Li Huang, Ning Xia
Summary: Passion fruit peel is rich in a variety of phenolic compounds, some of which have the ability to inhibit alpha-glucosidase activity. The bioactivity of PFPE phenols is significantly influenced by pH changes and digestive enzymes during simulated digestion, indicating the potential as natural antioxidants and alpha-glucosidase inhibitors.
Article
Horticulture
Annachiara Fioccardi, Dario Donno, Zoarilala Rinah Razafindrakoto, Giovanni Gamba, Gabriele Loris Beccaro
Summary: Traditional food and medicine are important in the daily lives of the local people in Madagascar. This study investigates the potential properties of leaf infusions of six plant species used as traditional beverages, finding high levels of antioxidants and beneficial compounds that can improve the health of the local population.
SCIENTIA HORTICULTURAE
(2022)
Article
Food Science & Technology
Michel M. Beya, Michael E. Netzel, Yasmina Sultanbawa, Heather Smyth, Louwrens C. Hoffman
Summary: Raw beef patties were treated with Kakadu plum powder, which effectively delayed lipid oxidation and microbial growth rate, reduced acidity and redness.
Article
Plant Sciences
Martin Backor, Michal Goga, Pragya Singh, Viktoria Tuptova
Summary: Aquatic habitats are frequently polluted with various xenobiotics, including heavy metals like copper. In this study, the sensitivity of the aquatic moss Taxiphyllum barbieri to excess copper was evaluated. It was found that excess copper negatively affected the moss's physiological and chemical characteristics. Cu accumulation in the moss was negatively correlated with decreased intracellular potassium content. The study suggests that this moss has potential for future use in water quality evaluation.
Review
Biochemistry & Molecular Biology
Atif Khurshid Wani, Nahid Akhtar, Tahir ul Gani Mir, Rattandeep Singh, Prakash Kumar Jha, Shyam Kumar Mallik, Shruti Sinha, Surya Kant Tripathi, Abha Jain, Aprajita Jha, Hari Prasad Devkota, Ajit Prakash
Summary: Apoptosis is the process of eliminating non-essential, neoplastic, and infected cells through regulated pathways. Loss of apoptosis control can lead to cancer cell survival, accumulation of mutations, and tumor progression. The apoptotic pathway has been studied as a potential drug target in cancer treatment, but concerns regarding off-target activities have emerged. Phytochemicals and plant-based nanoparticles show promise in cancer treatment by targeting programmed cell death network.
Article
Public, Environmental & Occupational Health
Mojca Hribersek, Fabian Eibensteiner, Lorenz Kapral, Anna Teufel, Faisal A. Nawaz, Merisa Cenanovic, Chandragiri Siva Sai, Hari Prasad Devkota, Ronita De, Rajeev K. Singla, Emil D. Parvanov, Christos Tsagkaris, Atanas G. Atanasov, Eva Schaden
Summary: This study explores the communication between hospital-based healthcare providers and patients' loved ones, focusing on the rigorous mitigation measures implemented during the COVID-19 pandemic. The findings highlight the importance of communication between patients, their loved ones, and hospitals, and the barriers to communication beyond visitation restrictions. The study emphasizes the implementation of family-centered care in adult nursing clinical practice.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Tsukasa Iwashina, Takahisa Nakane, Hari Prasad Devkota
Summary: Twenty-six flavonoids, including flavonols, C-glycosylflavones, flavanone, and anthocyanin, were isolated from the leaves and stems of Rhodiola ishidae. The major flavonoids were identified as flavonol glycosides based on herbacetin, gossypetin, kaempferol, and quercetin using various techniques such as UV spectral survey, HR-MS, LC-MS, acid hydrolysis, NMR, and HPLC and TLC comparisons. Three novel compounds, herbacetin 7-O-glucuronopyranoside-8-O-glucopyranoside, gossypetin 3-O-(2-malonylxylopyranoside)-8-O-glucopyranoside, and naringenin 7-O-sophoroside, were reported for the first time. The chemotaxonomic characteristics of flavonoids in R. ishidae were discussed.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2023)
Article
Chemistry, Medicinal
Tsukasa Iwashina, Hari Prasad Devkota, Takayuki Mizuno
CHEMISTRY OF NATURAL COMPOUNDS
(2023)
Review
Biochemistry & Molecular Biology
Mohammad Imran, Areeba Insaf, Nazeer Hasan, Vrushabh V. Sugandhi, Deumaya Shrestha, Keshav Raj Paudel, Saurav Kumar Jha, Philip M. Hansbro, Kamal Dua, Hari Prasad Devkota, Yousuf Mohammed
Summary: Plant-derived compounds, specifically antioxidants, play a crucial role in counteracting free radicals associated with diseases. Their ability to prevent and regulate the formation of radicals through decomposition has been extensively studied and documented. This review focuses on the molecular mechanisms of various flavonoids, such as quercetin, kaempferol, naringenin, epicatechin, and epicatechin gallate, and their potential in fighting against different types of cancers. Additionally, the application of nanotechnologies, including polymeric and lipid-based nanoparticles, liposomes, and metallic nanocarriers, for delivering these flavonoids in cancer treatment is discussed. Moreover, combination therapies involving flavonoids and other anti-cancer agents are explored, highlighting their effectiveness in managing various malignancies.
Article
Chemistry, Medicinal
Additiya Paramanya, Mohammad Abul Farah, Khalid Mashay Al-Anazi, Hari Prasad Devkota, Ahmad Ali
Summary: This study found that the aqueous extract of Spirulina has strong antioxidant and antiglycation properties, and can effectively prevent glycation and its secondary complications.
PHARMACOGNOSY MAGAZINE
(2023)
Review
Plant Sciences
Abhay Prakash Mishra, Pratichi Swetanshu, Pratichi Singh, Shikha Yadav, Manisha Nigam, Veronique Seidel, Celia Fortuna Rodrigues
Summary: Curcumin, a diarylheptanoid compound found in turmeric, has gained attention for its potential therapeutic effects in cancer. Various drug delivery approaches have been developed to optimize its pharmacokinetic profile and enhance its efficacy. Curcumin exhibits multiple biological activities, including anti-inflammatory, cardioprotective, antidiabetic, and anti-aging effects, and has been extensively studied for its role as a cancer chemopreventive and anticancer agent. This review focuses on curcumin's role in targeting cancer-related cell signaling pathways, including modulation of growth factors, transcription factors, kinases, enzymes, pro-inflammatory cytokines, and apoptotic proteins.
Review
Biology
I. Irem Tatli Cankaya, Hari Prasad Devkota, Gokhan Zengin, Dunja Samec
Summary: Neurological disorders are on the rise, and the search for molecules to treat them is intense. Natural components, particularly from the flavonoid group, have shown promise. Ginkgetin, a biflavonoid isolated from ginkgo plants, has demonstrated neuroprotective potential against ischemic strokes, neurotumors, Alzheimer's disease, and Parkinson's disease. Animal studies have shown beneficial effects, but further clinical trials are needed.
Article
Multidisciplinary Sciences
Summi Rai, Ananda Kafle, Hari Prasad Devkota, Ajaya Bhattarai
Summary: The surface-active properties of saponins extracted from Jatropha curcas L. leaves and stem bark were investigated in this study. Conductivity and surface tension measurements showed that Jatropha curcas saponin exhibited micellar behavior, with the average CMC values of 0.50 g/L and 0.75 g/L for leaf and stem bark saponin, respectively. Stem bark saponin demonstrated better surface activity and potential detergency, reducing the surface tension of water to a greater extent (γCMC = 37.65 mN/m) compared to leaf saponin (γCMC = 49.27 mN/m). The results suggest that both leaf and stem bark saponins from Jatropha curcas can be environmentally friendly alternatives to synthetic surfactants.
Article
Biotechnology & Applied Microbiology
Teppei Kawahara, Marin Ueda, Naoki Kishimoto, Tae Yasutake, Shogo Misumi, Hari Prasad Devkota, Mikiyo Wada
Summary: A new isoquinoline alkaloid, Amamine (1), was isolated from the culture extract of a Kitasatospora sp. HGTA304 actinomycete. The structure of 1 was determined using NMR, MS, and UV data analysis. Compound 1 showed α-glucosidase inhibitory potential (IC50 value of 56 μM) compared to the standard acarbose (IC50 value of 549 μM).
JOURNAL OF ANTIBIOTICS
(2023)
Review
Biochemistry & Molecular Biology
Ananda Lamichhane, Gopal Lamichhane, Hari Prasad Devkota
Summary: Yellow Himalayan raspberry is a native plant used traditionally as medicine and food. It contains various beneficial compounds, including macronutrients, minerals, and secondary metabolites. Scientific studies have shown its potential for health benefits such as antioxidant, anticancer, and anti-inflammatory activities. This plant has the potential to be developed as a nutraceutical and can improve the nutritional status of communities and contribute to the local economy if properly utilized and marketed.
Article
Chemistry, Applied
Janaki Baral, Dipesh Shrestha, Hari Prasad Devkota, Achyut Adhikari
Summary: Tambulin and prudomestin isolated from Zanthoxylum armatum DC showed potent ROS inhibition and antioxidant activity. They exhibited perfect binding affinity with COX-2 and had no toxic impact.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Jaya Arora, Bhanupriya Kanthaliya, Abhishek Joshi, Mukesh Meena, Supriya Meena, Manzer H. Siddiqui, Saud Alamri, Hari Prasad Devkota
Summary: This study investigated the changes in total isoflavones during sprouting of chickpea and the effects of precursor supplementation. It was found that increasing sprouting time up to the seventh day significantly increased isoflavone content. The supplementation of p-coumaric acid resulted in stunted sprouts while L-phenylalanine supplementation did not affect sprout length.
Article
Nutrition & Dietetics
Ravi Prakash Srivastava, Sachin Kumar, Lav Singh, Mayank Madhukar, Nitesh Singh, Gauri Saxena, Shivaraman Pandey, Arpit Singh, Hari Prasad Devkota, Praveen C. Verma, Shatrughan Shiva, Sumira Malik, Sarvesh Rustagi
Summary: Plant-derived phenolic compounds have potent antimicrobial, antifungal, and cytotoxic properties and act as antioxidants in treatments. This study evaluated the activities of extracts from different parts of S. carvifolia against cancer, bacteria, fungi, oxidation, and cytotoxicity. The extracts contained various phenolic compounds, with gallic acid having the highest concentration and chlorogenic acid having the lowest. The stem extract showed the highest TPC value and exhibited maximum antibacterial and antifungal activity. The extracts also demonstrated cytotoxicity against A549 cells, indicating their potential as anticancer agents. Rating: 9/10.
FRONTIERS IN NUTRITION
(2023)
Article
Agriculture, Multidisciplinary
Pooja Dixit, Nitesh Singh, Lav Singh, Ravi Prakash Srivastava, Shivaraman Pandey, Sanchita Singh, Arpit Singh, Hari Prasad Devkota, Parveen C. Verma, Gauri Saxena, Baber Ali, Rashid Iqbal, Sezai Ercisli
Summary: This study explores the biochemical profile and biological activities of Cephalotaxus and Taxus. The results show the presence of several medicinally important chemicals in these plants. However, the leaf and stem extracts of all six accessions showed no antimalarial activity.
ACS AGRICULTURAL SCIENCE & TECHNOLOGY
(2023)
